Cytokine Signaling in the Development and Homeostasis of Regulatory T cells

Cytokine signaling is indispensable for regulatory T-cell (Treg) development in the thymus, and also influences the homeostasis, phenotypic diversity, and function of Tregs in the periphery. Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating t...

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Veröffentlicht in:	Cold Spring Harbor perspectives in biology 2018-03, Vol.10 (3), p.a028597
Hauptverfasser:	Toomer, Kevin H, Malek, Thomas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines Cytokines - physiology Growth factors Homeostasis Humans Immunological tolerance Immunology Immunoregulation Interleukin 15 Interleukin 2 Interleukin 7 Interleukin-15 - physiology Interleukin-2 - physiology Interleukin-33 - physiology Interleukin-7 - physiology Lymphocytes Lymphocytes T PERSPECTIVES Signal Transduction - physiology Signaling T-Lymphocytes, Regulatory - immunology Thymic stromal lymphopoietin Thymus Transforming growth factor Transforming Growth Factor beta - physiology Transforming growth factor-b
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