Cytokine Signaling in the Development and Homeostasis of Regulatory T cells
Cytokine signaling is indispensable for regulatory T-cell (Treg) development in the thymus, and also influences the homeostasis, phenotypic diversity, and function of Tregs in the periphery. Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating t...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in biology 2018-03, Vol.10 (3), p.a028597 |
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| creator | Toomer, Kevin H Malek, Thomas R |
| description | Cytokine signaling is indispensable for regulatory T-cell (Treg) development in the thymus, and also influences the homeostasis, phenotypic diversity, and function of Tregs in the periphery. Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating the role of cytokines in Treg biology carries therapeutic potential in the context of autoimmune disease. This review discusses the potent and diverse influences of interleukin (IL)-2 signaling on the Treg compartment, an area of knowledge that has led to the use of low-dose IL-2 as a therapy to reregulate autoaggressive immune responses. Evidence suggesting Treg-specific impacts of the cytokines transforming growth factor β (TGF-β), IL-7, thymic stromal lymphopoietin (TSLP), IL-15, and IL-33 is also presented. Finally, we consider the technical challenges and knowledge limitations that must be overcome to bring other cytokine-based, Treg-targeted therapies into clinical use. |
| doi_str_mv | 10.1101/cshperspect.a028597 |
| format | Article |
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Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating the role of cytokines in Treg biology carries therapeutic potential in the context of autoimmune disease. This review discusses the potent and diverse influences of interleukin (IL)-2 signaling on the Treg compartment, an area of knowledge that has led to the use of low-dose IL-2 as a therapy to reregulate autoaggressive immune responses. Evidence suggesting Treg-specific impacts of the cytokines transforming growth factor β (TGF-β), IL-7, thymic stromal lymphopoietin (TSLP), IL-15, and IL-33 is also presented. 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Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating the role of cytokines in Treg biology carries therapeutic potential in the context of autoimmune disease. This review discusses the potent and diverse influences of interleukin (IL)-2 signaling on the Treg compartment, an area of knowledge that has led to the use of low-dose IL-2 as a therapy to reregulate autoaggressive immune responses. Evidence suggesting Treg-specific impacts of the cytokines transforming growth factor β (TGF-β), IL-7, thymic stromal lymphopoietin (TSLP), IL-15, and IL-33 is also presented. Finally, we consider the technical challenges and knowledge limitations that must be overcome to bring other cytokine-based, Treg-targeted therapies into clinical use.</description><subject>Animals</subject><subject>Cytokines</subject><subject>Cytokines - physiology</subject><subject>Growth factors</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immunological tolerance</subject><subject>Immunology</subject><subject>Immunoregulation</subject><subject>Interleukin 15</subject><subject>Interleukin 2</subject><subject>Interleukin 7</subject><subject>Interleukin-15 - physiology</subject><subject>Interleukin-2 - physiology</subject><subject>Interleukin-33 - physiology</subject><subject>Interleukin-7 - physiology</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>PERSPECTIVES</subject><subject>Signal Transduction - physiology</subject><subject>Signaling</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Thymic stromal lymphopoietin</subject><subject>Thymus</subject><subject>Transforming growth factor</subject><subject>Transforming Growth Factor beta - physiology</subject><subject>Transforming growth factor-b</subject><issn>1943-0264</issn><issn>1943-0264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUcFq3DAQFSWl2Wz7BYUgyCWXTSSNZUmXQtg03ZJAIdmehSxLu0psy5XswP59HbINm55mmHnzeG8eQl8puaCU0Eubt71LuXd2uDCESa7EBzSjqoAFYWVxdNAfo5OcHwkpSyXLT-iYyZIRouQM3S53Q3wKncMPYdOZJnQbHDo8bB2-ds-uiX3rugGbrsar2LqYB5NDxtHje7cZGzPEtMNrbF3T5M_oozdNdl_2dY5-33xfL1eLu18_fi6v7ha2ABgWAmoAX3lKpTBQC0tKooQxsiq55cA8qwrGKwfcGy58DdOcFYZxX1shRQ1z9O2Vtx-r1tV2EphMo_sUWpN2Opqg32-6sNWb-Ky5BCIVnwjO9wQp_hldHnQb8osF07k4Zk0VJUIBSDlBz_6DPsYxTY_KmlEopRK8YBMKXlE2xZyT829iKNEvYemDsPQ-rOnq9NDH282_dOAvU8OUuA</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Toomer, Kevin H</creator><creator>Malek, Thomas R</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180301</creationdate><title>Cytokine Signaling in the Development and Homeostasis of Regulatory T cells</title><author>Toomer, Kevin H ; Malek, Thomas R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-73d33fbf1187a3d7c06097aa8b65c532f2b425be35fa57fd3b6524a25fdc787d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cytokines</topic><topic>Cytokines - physiology</topic><topic>Growth factors</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immunological tolerance</topic><topic>Immunology</topic><topic>Immunoregulation</topic><topic>Interleukin 15</topic><topic>Interleukin 2</topic><topic>Interleukin 7</topic><topic>Interleukin-15 - physiology</topic><topic>Interleukin-2 - physiology</topic><topic>Interleukin-33 - physiology</topic><topic>Interleukin-7 - physiology</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>PERSPECTIVES</topic><topic>Signal Transduction - physiology</topic><topic>Signaling</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Thymic stromal lymphopoietin</topic><topic>Thymus</topic><topic>Transforming growth factor</topic><topic>Transforming Growth Factor beta - physiology</topic><topic>Transforming growth factor-b</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toomer, Kevin H</creatorcontrib><creatorcontrib>Malek, Thomas R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cold Spring Harbor perspectives in biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toomer, Kevin H</au><au>Malek, Thomas R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine Signaling in the Development and Homeostasis of Regulatory T cells</atitle><jtitle>Cold Spring Harbor perspectives in biology</jtitle><addtitle>Cold Spring Harb Perspect Biol</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>10</volume><issue>3</issue><spage>a028597</spage><pages>a028597-</pages><issn>1943-0264</issn><eissn>1943-0264</eissn><abstract>Cytokine signaling is indispensable for regulatory T-cell (Treg) development in the thymus, and also influences the homeostasis, phenotypic diversity, and function of Tregs in the periphery. Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating the role of cytokines in Treg biology carries therapeutic potential in the context of autoimmune disease. This review discusses the potent and diverse influences of interleukin (IL)-2 signaling on the Treg compartment, an area of knowledge that has led to the use of low-dose IL-2 as a therapy to reregulate autoaggressive immune responses. Evidence suggesting Treg-specific impacts of the cytokines transforming growth factor β (TGF-β), IL-7, thymic stromal lymphopoietin (TSLP), IL-15, and IL-33 is also presented. Finally, we consider the technical challenges and knowledge limitations that must be overcome to bring other cytokine-based, Treg-targeted therapies into clinical use.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>28620098</pmid><doi>10.1101/cshperspect.a028597</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Cytokines Cytokines - physiology Growth factors Homeostasis Humans Immunological tolerance Immunology Immunoregulation Interleukin 15 Interleukin 2 Interleukin 7 Interleukin-15 - physiology Interleukin-2 - physiology Interleukin-33 - physiology Interleukin-7 - physiology Lymphocytes Lymphocytes T PERSPECTIVES Signal Transduction - physiology Signaling T-Lymphocytes, Regulatory - immunology Thymic stromal lymphopoietin Thymus Transforming growth factor Transforming Growth Factor beta - physiology Transforming growth factor-b |
| title | Cytokine Signaling in the Development and Homeostasis of Regulatory T cells |
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