Timescales of Intrinsic BOLD Signal Dynamics and Functional Connectivity in Pharmacologic and Neuropathologic States of Unconsciousness
Environmental events are processed on multiple timescales via hierarchical organization of temporal receptive windows (TRWs) in the brain. The dependence of neural timescales and TRWs on altered states of consciousness is unclear. States of reduced consciousness are marked by a shift toward slowing...
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| Veröffentlicht in: | The Journal of neuroscience 2018-02, Vol.38 (9), p.2304-2317 |
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| creator | Huang, Zirui Liu, Xiaolin Mashour, George A Hudetz, Anthony G |
| description | Environmental events are processed on multiple timescales via hierarchical organization of temporal receptive windows (TRWs) in the brain. The dependence of neural timescales and TRWs on altered states of consciousness is unclear. States of reduced consciousness are marked by a shift toward slowing of neural dynamics ( |
| doi_str_mv | 10.1523/JNEUROSCI.2545-17.2018 |
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= 23; male/female 14/9) during graded sedation with propofol. We further examined the relationship between the intrinsic timescales (local/voxel level) and its regional connectivity (across neighboring voxels; regional homogeneity, ReHo), global (whole-brain level) functional connectivity (GFC), and topographical similarity (Topo). Additional results were obtained from patients undergoing deep general anesthesia (
= 12; male/female: 5/7) and in patients with disorders of consciousness (DOC) (
= 21; male/female: 14/7). We found that MF, AC, and ReHo increased, whereas GFC and Topo decreased, during propofol sedation. The local alterations occur before changes of distant connectivity. Conversely, all of these parameters decreased in deep anesthesia and in patients with DOC. We conclude that propofol synchronizes local neuronal interactions and prolongs the timescales of intrinsic BOLD signals. These effects may impede communication among distant brain regions. Furthermore, the intrinsic timescales exhibit distinct dynamic signatures in sedation, deep anesthesia, and DOC. These results improve our understanding of the neural mechanisms of unconsciousness in pharmacologic and neuropathologic states.
Information processing in the brain occurs through a hierarchy of temporal receptive windows (TRWs) in multiple timescales. Anesthetic drugs induce a reversible suppression of consciousness and thus offer a unique opportunity to investigate the state dependence of neural timescales. Here, we demonstrate for the first time that sedation with propofol is accompanied by the prolongation of the timescales of intrinsic BOLD signals presumably reflecting enlarged TRWs. We show that this is accomplished by an increase of local and regional signal synchronization, effects that may disrupt information exchange among distant brain regions. Furthermore, we show that the timescales of intrinsic BOLD signals exhibit distinct dynamic signatures in sedation, deep anesthesia, and disorders of consciousness.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/JNEUROSCI.2545-17.2018</identifier><identifier>PMID: 29386261</identifier><language>eng</language><publisher>United States: Society for Neuroscience</publisher><subject>Adult ; Anesthesia ; Brain ; Brain - drug effects ; Brain - physiology ; Consciousness ; Data processing ; Dependence ; Disorders ; EEG ; Electroencephalography ; Female ; Homogeneity ; Humans ; Hypnotics and Sedatives - pharmacology ; Information processing ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural networks ; Neural Pathways - drug effects ; Neural Pathways - physiology ; Neuropathology ; Patients ; Pharmacology ; Prolongation ; Propofol ; Propofol - pharmacology ; Signatures ; Synchronism ; Synchronization ; Unconsciousness ; Unconsciousness - chemically induced ; Unconsciousness - physiopathology ; Young Adult</subject><ispartof>The Journal of neuroscience, 2018-02, Vol.38 (9), p.2304-2317</ispartof><rights>Copyright © 2018 Huang et al.</rights><rights>Copyright Society for Neuroscience Feb 28, 2018</rights><rights>Copyright © 2018 Huang et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-b8e33f44876636d42489f00f11616e9ebeacb9b0017a53e35928e25cc8d1cd033</citedby><cites>FETCH-LOGICAL-c442t-b8e33f44876636d42489f00f11616e9ebeacb9b0017a53e35928e25cc8d1cd033</cites><orcidid>0000-0002-5949-0206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830518/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830518/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29386261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Zirui</creatorcontrib><creatorcontrib>Liu, Xiaolin</creatorcontrib><creatorcontrib>Mashour, George A</creatorcontrib><creatorcontrib>Hudetz, Anthony G</creatorcontrib><title>Timescales of Intrinsic BOLD Signal Dynamics and Functional Connectivity in Pharmacologic and Neuropathologic States of Unconsciousness</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Environmental events are processed on multiple timescales via hierarchical organization of temporal receptive windows (TRWs) in the brain. The dependence of neural timescales and TRWs on altered states of consciousness is unclear. States of reduced consciousness are marked by a shift toward slowing of neural dynamics (<1 Hz) in EEG/ECoG signals. We hypothesize that such prolongation of intrinsic timescales are also seen in blood-oxygen-level-dependent (BOLD) signals. To test this hypothesis, we measured the timescales of intrinsic BOLD signals using mean frequency (MF) and temporal autocorrelation (AC) in healthy volunteers (
= 23; male/female 14/9) during graded sedation with propofol. We further examined the relationship between the intrinsic timescales (local/voxel level) and its regional connectivity (across neighboring voxels; regional homogeneity, ReHo), global (whole-brain level) functional connectivity (GFC), and topographical similarity (Topo). Additional results were obtained from patients undergoing deep general anesthesia (
= 12; male/female: 5/7) and in patients with disorders of consciousness (DOC) (
= 21; male/female: 14/7). We found that MF, AC, and ReHo increased, whereas GFC and Topo decreased, during propofol sedation. The local alterations occur before changes of distant connectivity. Conversely, all of these parameters decreased in deep anesthesia and in patients with DOC. We conclude that propofol synchronizes local neuronal interactions and prolongs the timescales of intrinsic BOLD signals. These effects may impede communication among distant brain regions. Furthermore, the intrinsic timescales exhibit distinct dynamic signatures in sedation, deep anesthesia, and DOC. These results improve our understanding of the neural mechanisms of unconsciousness in pharmacologic and neuropathologic states.
Information processing in the brain occurs through a hierarchy of temporal receptive windows (TRWs) in multiple timescales. Anesthetic drugs induce a reversible suppression of consciousness and thus offer a unique opportunity to investigate the state dependence of neural timescales. Here, we demonstrate for the first time that sedation with propofol is accompanied by the prolongation of the timescales of intrinsic BOLD signals presumably reflecting enlarged TRWs. We show that this is accomplished by an increase of local and regional signal synchronization, effects that may disrupt information exchange among distant brain regions. Furthermore, we show that the timescales of intrinsic BOLD signals exhibit distinct dynamic signatures in sedation, deep anesthesia, and disorders of consciousness.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Consciousness</subject><subject>Data processing</subject><subject>Dependence</subject><subject>Disorders</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Homogeneity</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Information processing</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neural networks</subject><subject>Neural Pathways - drug effects</subject><subject>Neural Pathways - physiology</subject><subject>Neuropathology</subject><subject>Patients</subject><subject>Pharmacology</subject><subject>Prolongation</subject><subject>Propofol</subject><subject>Propofol - pharmacology</subject><subject>Signatures</subject><subject>Synchronism</subject><subject>Synchronization</subject><subject>Unconsciousness</subject><subject>Unconsciousness - chemically induced</subject><subject>Unconsciousness - physiopathology</subject><subject>Young Adult</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9q2zAUxsXYWLOur1AMu9mNU_23dDPY0nbNCM1ommshy3KiYkupZRfyBHvtySQLa6-EzvnOd_TpB8AlglPEMLn6dX-zfliuZvMpZpTlqJhiiMQ7MEldmWMK0XswgbiAOacFPQOfYnyCEBYQFR_BGZZEcMzRBPx5dK2NRjc2ZqHO5r7vnI_OZD-Wi-ts5TZeN9n13uvWmZhpX2W3gze9C2N9Fry36fLi-n3mfPZ7q7tWm9CETXIYxfd26MJO99tjbdXr_rBp7U3w0bgwRG9j_Aw-1LqJ9uJ4noP17c3j7C5fLH_OZ98XuaEU93kpLCE1paLgnPCKYipkDWGNEEfcSltabUpZwhRTM2IJk1hYzIwRFTIVJOQcfDv47oaytZWxKbBu1K5zre72KminXne826pNeFFMEMiQSAZfjwZdeB5s7FXrorFNo71NWRSSkhDBioIl6Zc30qcwdOnjosJQUioJwjyp-EFluhBjZ-vTYxBUI2t1Yq1G1goVamSdBi__j3Ia-weX_AXuL6jx</recordid><startdate>20180228</startdate><enddate>20180228</enddate><creator>Huang, Zirui</creator><creator>Liu, Xiaolin</creator><creator>Mashour, George A</creator><creator>Hudetz, Anthony G</creator><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5949-0206</orcidid></search><sort><creationdate>20180228</creationdate><title>Timescales of Intrinsic BOLD Signal Dynamics and Functional Connectivity in Pharmacologic and Neuropathologic States of Unconsciousness</title><author>Huang, Zirui ; Liu, Xiaolin ; Mashour, George A ; Hudetz, Anthony G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-b8e33f44876636d42489f00f11616e9ebeacb9b0017a53e35928e25cc8d1cd033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Consciousness</topic><topic>Data processing</topic><topic>Dependence</topic><topic>Disorders</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Homogeneity</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Information processing</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neural networks</topic><topic>Neural Pathways - drug effects</topic><topic>Neural Pathways - physiology</topic><topic>Neuropathology</topic><topic>Patients</topic><topic>Pharmacology</topic><topic>Prolongation</topic><topic>Propofol</topic><topic>Propofol - pharmacology</topic><topic>Signatures</topic><topic>Synchronism</topic><topic>Synchronization</topic><topic>Unconsciousness</topic><topic>Unconsciousness - chemically induced</topic><topic>Unconsciousness - physiopathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Zirui</creatorcontrib><creatorcontrib>Liu, Xiaolin</creatorcontrib><creatorcontrib>Mashour, George A</creatorcontrib><creatorcontrib>Hudetz, Anthony G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Zirui</au><au>Liu, Xiaolin</au><au>Mashour, George A</au><au>Hudetz, Anthony G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Timescales of Intrinsic BOLD Signal Dynamics and Functional Connectivity in Pharmacologic and Neuropathologic States of Unconsciousness</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2018-02-28</date><risdate>2018</risdate><volume>38</volume><issue>9</issue><spage>2304</spage><epage>2317</epage><pages>2304-2317</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>Environmental events are processed on multiple timescales via hierarchical organization of temporal receptive windows (TRWs) in the brain. The dependence of neural timescales and TRWs on altered states of consciousness is unclear. States of reduced consciousness are marked by a shift toward slowing of neural dynamics (<1 Hz) in EEG/ECoG signals. We hypothesize that such prolongation of intrinsic timescales are also seen in blood-oxygen-level-dependent (BOLD) signals. To test this hypothesis, we measured the timescales of intrinsic BOLD signals using mean frequency (MF) and temporal autocorrelation (AC) in healthy volunteers (
= 23; male/female 14/9) during graded sedation with propofol. We further examined the relationship between the intrinsic timescales (local/voxel level) and its regional connectivity (across neighboring voxels; regional homogeneity, ReHo), global (whole-brain level) functional connectivity (GFC), and topographical similarity (Topo). Additional results were obtained from patients undergoing deep general anesthesia (
= 12; male/female: 5/7) and in patients with disorders of consciousness (DOC) (
= 21; male/female: 14/7). We found that MF, AC, and ReHo increased, whereas GFC and Topo decreased, during propofol sedation. The local alterations occur before changes of distant connectivity. Conversely, all of these parameters decreased in deep anesthesia and in patients with DOC. We conclude that propofol synchronizes local neuronal interactions and prolongs the timescales of intrinsic BOLD signals. These effects may impede communication among distant brain regions. Furthermore, the intrinsic timescales exhibit distinct dynamic signatures in sedation, deep anesthesia, and DOC. These results improve our understanding of the neural mechanisms of unconsciousness in pharmacologic and neuropathologic states.
Information processing in the brain occurs through a hierarchy of temporal receptive windows (TRWs) in multiple timescales. Anesthetic drugs induce a reversible suppression of consciousness and thus offer a unique opportunity to investigate the state dependence of neural timescales. Here, we demonstrate for the first time that sedation with propofol is accompanied by the prolongation of the timescales of intrinsic BOLD signals presumably reflecting enlarged TRWs. We show that this is accomplished by an increase of local and regional signal synchronization, effects that may disrupt information exchange among distant brain regions. Furthermore, we show that the timescales of intrinsic BOLD signals exhibit distinct dynamic signatures in sedation, deep anesthesia, and disorders of consciousness.</abstract><cop>United States</cop><pub>Society for Neuroscience</pub><pmid>29386261</pmid><doi>10.1523/JNEUROSCI.2545-17.2018</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-5949-0206</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anesthesia Brain Brain - drug effects Brain - physiology Consciousness Data processing Dependence Disorders EEG Electroencephalography Female Homogeneity Humans Hypnotics and Sedatives - pharmacology Information processing Magnetic Resonance Imaging Male Middle Aged Neural networks Neural Pathways - drug effects Neural Pathways - physiology Neuropathology Patients Pharmacology Prolongation Propofol Propofol - pharmacology Signatures Synchronism Synchronization Unconsciousness Unconsciousness - chemically induced Unconsciousness - physiopathology Young Adult |
| title | Timescales of Intrinsic BOLD Signal Dynamics and Functional Connectivity in Pharmacologic and Neuropathologic States of Unconsciousness |
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