Systematic editing of synthetic RIG-I ligands to produce effective antiviral and anti-tumor RNA immunotherapies

Abstract Retinoic acid-inducible gene I (RIG-I) recognizes double-stranded viral RNAs (dsRNAs) containing two or three 5′ phosphates. A few reports of 5′-PPP-independent RIG-I agonists have emerged, but little is known about the molecular principles underlying their recognition. We recently found th...

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Veröffentlicht in:	Nucleic acids research 2018-02, Vol.46 (4), p.1635-1647
Hauptverfasser:	Lee, Janghyun, Park, Eun-Byeol, Min, Jiyoun, Sung, Si-Eun, Jang, Yejin, Shin, Jin Soo, Chun, Dongmin, Kim, Ki-Hun, Hwang, Jihyun, Lee, Mi-Kyung, Go, Yun Young, Kwon, Dohyeong, Kim, Meehyein, Kang, Suk-Jo, Choi, Byong-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Biology and Nucleic Acid Chemistry
Online-Zugang:	Volltext
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