PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway

Abstract The DNA-dependent protein kinase (DNA-PK), consisting of the DNA binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs, has been well characterized in the non-homologous end-joining mechanism for DNA double strand break (DSB) repair and radiation resistance. Besides playing a role...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 2018-02, Vol.46 (4), p.1847-1859
Hauptverfasser:	Lin, Yu-Fen, Shih, Hung-Ying, Shang, Zeng-Fu, Kuo, Ching-Te, Guo, Jiaming, Du, Chunying, Lee, Hsinyu, Chen, Benjamin P C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Ataxia Telangiectasia Mutated Proteins - metabolism Cell Line Cricetinae Death Domain Receptor Signaling Adaptor Proteins - metabolism DNA Replication DNA-Activated Protein Kinase - chemistry DNA-Activated Protein Kinase - metabolism Genome Integrity, Repair and Humans Ku Autoantigen - physiology Nuclear Proteins - chemistry Nuclear Proteins - metabolism S Phase Cell Cycle Checkpoints Signal Transduction Stress, Physiological Ultraviolet Rays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!