Interleukin-1 signaling in the basolateral amygdala is necessary for heroin-conditioned immunosuppression

Highlights • Heroin-conditioned immunosuppression expression requires the basolateral amygdala. • Expression is attenuated specifically by IL-1 blockade in the basolateral amygdala. • IL-1 blockade in other candidate brain regions had no effect on expression. • Amygdala IL-1 signaling is important f...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-05, Vol.62, p.171-179
Hauptverfasser:	Hutson, Lee W, Lebonville, Christina L, Jones, Meghan E, Fuchs, Rita A, Lysle, Donald T
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Basolateral amygdala Basolateral Nuclear Complex - drug effects Basolateral Nuclear Complex - metabolism Conditioning, Psychological - drug effects Heroin Heroin - pharmacology IL-1 IL-1 receptor antagonist Immune conditioning, opioid Immunosuppression Therapy Interleukin 1 Receptor Antagonist Protein - pharmacology Learning Male Narcotics - pharmacology Nitric oxide Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Psychiatry Rats Receptors, Interleukin-1 - metabolism Signal Transduction - drug effects
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Zusammenfassung:	Highlights • Heroin-conditioned immunosuppression expression requires the basolateral amygdala. • Expression is attenuated specifically by IL-1 blockade in the basolateral amygdala. • IL-1 blockade in other candidate brain regions had no effect on expression. • Amygdala IL-1 signaling is important for conditioned immunosuppression with heroin.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2017.01.017