Closing in on the Mechanisms of Pulsatile Insulin Secretion

Insulin secretion from pancreatic islet β-cells occurs in a pulsatile fashion, with a typical period of ∼5 min. The basis of this pulsatility in mouse islets has been investigated for more than four decades, and the various theories have been described as either qualitative or mathematical models. I...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2018-03, Vol.67 (3), p.351-359
Hauptverfasser:	Bertram, Richard, Satin, Leslie S, Sherman, Arthur S
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animal models Animals Blood Glucose - metabolism Calcium Signaling Cells Computer Simulation Enzyme Activation Fructosediphosphates - metabolism Glycolysis Humans Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - metabolism Intracellular Islets of Langerhans Kinetics Mathematical models Metabolism Models, Biological Oscillations Pancreas Phosphofructokinase-1, Muscle Type - metabolism Pyruvate Dehydrogenase Complex - chemistry Pyruvate Dehydrogenase Complex - metabolism s in Diabetes Secretion
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