Retinal changes in diabetic patients without diabetic retinopathy
The purpose of this study was to measure retinal vessel caliber and to examine early changes in macular thickness using optical coherence tomography (OCT). We evaluated to what extend vascular caliber and macular thickness differed between patients with type 2 diabetes mellitus without diabetic reti...
Gespeichert in:
| Veröffentlicht in: | Romanian journal of ophthalmology 2017-10, Vol.61 (4), p.249-255 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 255 |
|---|---|
| container_issue | 4 |
| container_start_page | 249 |
| container_title | Romanian journal of ophthalmology |
| container_volume | 61 |
| creator | Dumitrescu, Alina Gabriela Istrate, Sinziana Luminita Iancu, Raluca Claudia Guta, Oana Maria Ciuluvica, Radu Voinea, Liliana |
| description | The purpose of this study was to measure retinal vessel caliber and to examine early changes in macular thickness using optical coherence tomography (OCT). We evaluated to what extend vascular caliber and macular thickness differed between patients with type 2 diabetes mellitus without diabetic retinopathy compared with healthy individuals.
26 diabetic patients without diabetic retinopathy and 26 normal participants without any retinal and optic nerve diseases underwent ophthalmic examination, fundus photography, and OCT imaging. Temporal inferior retinal vessel diameters were measured using OCT. Also, we measured macular thickness in nine ETDRS subfields using Cirrus OCT.
The mean age in the diabetic group was 61.5 years and in the control group, 55.5 years. Wider retinal arterioles and venules were found in patients with diabetes compared with healthy subjects (120 µm versus 96 µm, p |
| doi_str_mv | 10.22336/rjo.2017.45 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5827140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2012114915</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2295-c323084346e17d8672ff1ab07d1a08ece5939adbb02020e1e02313e9f347dceb3</originalsourceid><addsrcrecordid>eNpVUE1Lw0AQXUSxUnvzLDl6MHU_s8lFKMUvKAii52WzmTRb0mzdTZX-e7e2VmUOM8x7897wELogeEwpY9mNX7gxxUSOuThCZ1RgklLB2HGcuZApZ1QM0CiEBcaYFLzAQpyiAS0EyTBnZ2jyAr3tdJuYRndzCIntksrqMm5NstK9ha4PyaftG7fufxG_vXIRbzbn6KTWbYDRvg_R2_3d6_QxnT0_PE0ns9TQaJcaRhnOOeMZEFnlmaR1TXSJZUU0zsGAKFihq7LENBYQwJQRBkXNuKwMlGyIbne6q3W5hLjqeq9btfJ2qf1GOW3Vf6SzjZq7DyVyKgnHUeBqL-Dd-xpCr5Y2GGhb3YFbBxVjpITwgohIvd5RjXcheKgPNgSr7-BVDH57IRXf0i__vnYg_8TMvgDs6H9Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2012114915</pqid></control><display><type>article</type><title>Retinal changes in diabetic patients without diabetic retinopathy</title><source>MEDLINE</source><source>PubMed Central</source><creator>Dumitrescu, Alina Gabriela ; Istrate, Sinziana Luminita ; Iancu, Raluca Claudia ; Guta, Oana Maria ; Ciuluvica, Radu ; Voinea, Liliana</creator><creatorcontrib>Dumitrescu, Alina Gabriela ; Istrate, Sinziana Luminita ; Iancu, Raluca Claudia ; Guta, Oana Maria ; Ciuluvica, Radu ; Voinea, Liliana</creatorcontrib><description>The purpose of this study was to measure retinal vessel caliber and to examine early changes in macular thickness using optical coherence tomography (OCT). We evaluated to what extend vascular caliber and macular thickness differed between patients with type 2 diabetes mellitus without diabetic retinopathy compared with healthy individuals.
26 diabetic patients without diabetic retinopathy and 26 normal participants without any retinal and optic nerve diseases underwent ophthalmic examination, fundus photography, and OCT imaging. Temporal inferior retinal vessel diameters were measured using OCT. Also, we measured macular thickness in nine ETDRS subfields using Cirrus OCT.
The mean age in the diabetic group was 61.5 years and in the control group, 55.5 years. Wider retinal arterioles and venules were found in patients with diabetes compared with healthy subjects (120 µm versus 96 µm, p<0.005 and 137 µm versus 120.5 µm, p value <0.001, respectively). In patients with type 2 diabetes mellitus, central macular thickness was significantly thinner than that of control eyes (243.5 µm versus 269.9 µm, p value <0.001).
Our results support the hypothesis that the association between vascular damage and structural changes of the neuroretina is an early indicator of retinal impairment in patients with diabetes without diabetic retinopathy.</description><identifier>ISSN: 2457-4325</identifier><identifier>EISSN: 2501-2533</identifier><identifier>DOI: 10.22336/rjo.2017.45</identifier><identifier>PMID: 29516043</identifier><language>eng</language><publisher>Romania: Romanian Society of Ophthalmology</publisher><subject>Case-Control Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetic Retinopathy - complications ; Humans ; Macular Edema ; Middle Aged ; Retina - physiology ; Tomography, Optical Coherence</subject><ispartof>Romanian journal of ophthalmology, 2017-10, Vol.61 (4), p.249-255</ispartof><rights>Romanian Society of Ophthalmology 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2295-c323084346e17d8672ff1ab07d1a08ece5939adbb02020e1e02313e9f347dceb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827140/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827140/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29516043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dumitrescu, Alina Gabriela</creatorcontrib><creatorcontrib>Istrate, Sinziana Luminita</creatorcontrib><creatorcontrib>Iancu, Raluca Claudia</creatorcontrib><creatorcontrib>Guta, Oana Maria</creatorcontrib><creatorcontrib>Ciuluvica, Radu</creatorcontrib><creatorcontrib>Voinea, Liliana</creatorcontrib><title>Retinal changes in diabetic patients without diabetic retinopathy</title><title>Romanian journal of ophthalmology</title><addtitle>Rom J Ophthalmol</addtitle><description>The purpose of this study was to measure retinal vessel caliber and to examine early changes in macular thickness using optical coherence tomography (OCT). We evaluated to what extend vascular caliber and macular thickness differed between patients with type 2 diabetes mellitus without diabetic retinopathy compared with healthy individuals.
26 diabetic patients without diabetic retinopathy and 26 normal participants without any retinal and optic nerve diseases underwent ophthalmic examination, fundus photography, and OCT imaging. Temporal inferior retinal vessel diameters were measured using OCT. Also, we measured macular thickness in nine ETDRS subfields using Cirrus OCT.
The mean age in the diabetic group was 61.5 years and in the control group, 55.5 years. Wider retinal arterioles and venules were found in patients with diabetes compared with healthy subjects (120 µm versus 96 µm, p<0.005 and 137 µm versus 120.5 µm, p value <0.001, respectively). In patients with type 2 diabetes mellitus, central macular thickness was significantly thinner than that of control eyes (243.5 µm versus 269.9 µm, p value <0.001).
Our results support the hypothesis that the association between vascular damage and structural changes of the neuroretina is an early indicator of retinal impairment in patients with diabetes without diabetic retinopathy.</description><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Retinopathy - complications</subject><subject>Humans</subject><subject>Macular Edema</subject><subject>Middle Aged</subject><subject>Retina - physiology</subject><subject>Tomography, Optical Coherence</subject><issn>2457-4325</issn><issn>2501-2533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUE1Lw0AQXUSxUnvzLDl6MHU_s8lFKMUvKAii52WzmTRb0mzdTZX-e7e2VmUOM8x7897wELogeEwpY9mNX7gxxUSOuThCZ1RgklLB2HGcuZApZ1QM0CiEBcaYFLzAQpyiAS0EyTBnZ2jyAr3tdJuYRndzCIntksrqMm5NstK9ha4PyaftG7fufxG_vXIRbzbn6KTWbYDRvg_R2_3d6_QxnT0_PE0ns9TQaJcaRhnOOeMZEFnlmaR1TXSJZUU0zsGAKFihq7LENBYQwJQRBkXNuKwMlGyIbne6q3W5hLjqeq9btfJ2qf1GOW3Vf6SzjZq7DyVyKgnHUeBqL-Dd-xpCr5Y2GGhb3YFbBxVjpITwgohIvd5RjXcheKgPNgSr7-BVDH57IRXf0i__vnYg_8TMvgDs6H9Q</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Dumitrescu, Alina Gabriela</creator><creator>Istrate, Sinziana Luminita</creator><creator>Iancu, Raluca Claudia</creator><creator>Guta, Oana Maria</creator><creator>Ciuluvica, Radu</creator><creator>Voinea, Liliana</creator><general>Romanian Society of Ophthalmology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201710</creationdate><title>Retinal changes in diabetic patients without diabetic retinopathy</title><author>Dumitrescu, Alina Gabriela ; Istrate, Sinziana Luminita ; Iancu, Raluca Claudia ; Guta, Oana Maria ; Ciuluvica, Radu ; Voinea, Liliana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2295-c323084346e17d8672ff1ab07d1a08ece5939adbb02020e1e02313e9f347dceb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Retinopathy - complications</topic><topic>Humans</topic><topic>Macular Edema</topic><topic>Middle Aged</topic><topic>Retina - physiology</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dumitrescu, Alina Gabriela</creatorcontrib><creatorcontrib>Istrate, Sinziana Luminita</creatorcontrib><creatorcontrib>Iancu, Raluca Claudia</creatorcontrib><creatorcontrib>Guta, Oana Maria</creatorcontrib><creatorcontrib>Ciuluvica, Radu</creatorcontrib><creatorcontrib>Voinea, Liliana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Romanian journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dumitrescu, Alina Gabriela</au><au>Istrate, Sinziana Luminita</au><au>Iancu, Raluca Claudia</au><au>Guta, Oana Maria</au><au>Ciuluvica, Radu</au><au>Voinea, Liliana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal changes in diabetic patients without diabetic retinopathy</atitle><jtitle>Romanian journal of ophthalmology</jtitle><addtitle>Rom J Ophthalmol</addtitle><date>2017-10</date><risdate>2017</risdate><volume>61</volume><issue>4</issue><spage>249</spage><epage>255</epage><pages>249-255</pages><issn>2457-4325</issn><eissn>2501-2533</eissn><abstract>The purpose of this study was to measure retinal vessel caliber and to examine early changes in macular thickness using optical coherence tomography (OCT). We evaluated to what extend vascular caliber and macular thickness differed between patients with type 2 diabetes mellitus without diabetic retinopathy compared with healthy individuals.
26 diabetic patients without diabetic retinopathy and 26 normal participants without any retinal and optic nerve diseases underwent ophthalmic examination, fundus photography, and OCT imaging. Temporal inferior retinal vessel diameters were measured using OCT. Also, we measured macular thickness in nine ETDRS subfields using Cirrus OCT.
The mean age in the diabetic group was 61.5 years and in the control group, 55.5 years. Wider retinal arterioles and venules were found in patients with diabetes compared with healthy subjects (120 µm versus 96 µm, p<0.005 and 137 µm versus 120.5 µm, p value <0.001, respectively). In patients with type 2 diabetes mellitus, central macular thickness was significantly thinner than that of control eyes (243.5 µm versus 269.9 µm, p value <0.001).
Our results support the hypothesis that the association between vascular damage and structural changes of the neuroretina is an early indicator of retinal impairment in patients with diabetes without diabetic retinopathy.</abstract><cop>Romania</cop><pub>Romanian Society of Ophthalmology</pub><pmid>29516043</pmid><doi>10.22336/rjo.2017.45</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2457-4325 |
| ispartof | Romanian journal of ophthalmology, 2017-10, Vol.61 (4), p.249-255 |
| issn | 2457-4325 2501-2533 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5827140 |
| source | MEDLINE; PubMed Central |
| subjects | Case-Control Studies Diabetes Mellitus, Type 2 - complications Diabetic Retinopathy - complications Humans Macular Edema Middle Aged Retina - physiology Tomography, Optical Coherence |
| title | Retinal changes in diabetic patients without diabetic retinopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A09%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinal%20changes%20in%20diabetic%20patients%20without%20diabetic%20retinopathy&rft.jtitle=Romanian%20journal%20of%20ophthalmology&rft.au=Dumitrescu,%20Alina%20Gabriela&rft.date=2017-10&rft.volume=61&rft.issue=4&rft.spage=249&rft.epage=255&rft.pages=249-255&rft.issn=2457-4325&rft.eissn=2501-2533&rft_id=info:doi/10.22336/rjo.2017.45&rft_dat=%3Cproquest_pubme%3E2012114915%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2012114915&rft_id=info:pmid/29516043&rfr_iscdi=true |