VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage

Cardioviruses cause diseases in many animals including, in rare cases, humans. Although they share common features with all picornaviruses, cardioviruses have unique properties that distinguish them from other family members, including enteroviruses. One feature shared by all picornaviruses is the c...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2018-03, Vol.516, p.139-146
Hauptverfasser:	Maciejewski, Sonia, Ullmer, Wendy, Semler, Bert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	5′ tyrosyl-DNA phosphodiesterase 2 Animals Cardiovirus Cardiovirus - genetics Cardiovirus - metabolism Cardiovirus Infections - genetics Cardiovirus Infections - metabolism Cardiovirus Infections - virology Cell Nucleus - genetics Cell Nucleus - metabolism Cytoplasm - genetics Cytoplasm - metabolism EMCV Encephalomyocarditis virus Fibroblasts - metabolism HeLa Cells Host-Pathogen Interactions Humans Mice Mice, Knockout Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Picornavirus Protein Transport Proteolysis RNA, Viral - genetics RNA, Viral - metabolism TDP2 Transcription Factors - genetics Transcription Factors - metabolism Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism Viral Proteins - genetics Viral Proteins - metabolism Virus Replication Virus-host interactions
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