Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude. How brown fat keeps us from the cold Brown adipose tissue (BAT), or brown fat, protects against hypothermia by generating heat. Mitchell Lazar and colleagues discovered a critical and...

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Veröffentlicht in:	Nature (London) 2017-06, Vol.546 (7659), p.544-548
Hauptverfasser:	Emmett, Matthew J., Lim, Hee-Woong, Jager, Jennifer, Richter, Hannah J., Adlanmerini, Marine, Peed, Lindsey C., Briggs, Erika R., Steger, David J., Ma, Tao, Sims, Carrie A., Baur, Joseph A., Pei, Liming, Won, Kyoung-Jae, Seale, Patrick, Gerhart-Hines, Zachary, Lazar, Mitchell A.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/109 38/91 45/15 45/91 631/337/572/2102 631/443/319/1557 64/60 82/80 Adipose tissue Adipose Tissue, Brown - metabolism Animals Brown adipose tissue Cell Respiration Cold Temperature Enhancer Elements, Genetic - genetics Enzymes ERRalpha Estrogen-Related Receptor Gene Expression Regulation Histone Deacetylases - metabolism Histones Hot Temperature Humanities and Social Sciences Humans letter Male Mice Mitochondria - metabolism multidisciplinary Oxidative Phosphorylation Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Physiological aspects Physiological research Receptors, Estrogen - metabolism Science Thermogenesis Thermogenesis - genetics Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism
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