Biopolymer Molecular Weight Can Modulate the Wound Healing Efficacy of Multivalent Sonic Hedgehog–Hyaluronic Acid Conjugates

There is a clinical need for new therapeutics to improve healing of chronic impaired wounds. Thus, we investigated how biopolymer conjugation could be used to improve the wound healing performance of a key growth factor for tissue regeneration: Sonic hedgehog (Shh). We generated two multivalent Shh...

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Veröffentlicht in:	Biomacromolecules 2017-08, Vol.18 (8), p.2350-2359
Hauptverfasser:	Holstlaw, Taylor A, Mahomed, Mavish, Brier, Livia W, Young, David M, Boudreau, Nancy J, Jackson, Wesley M
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis animal disease models Animals biopolymers Cell Line diabetes Fibroblasts - metabolism Hedgehog Proteins - chemistry Hedgehog Proteins - pharmacology hyaluronic acid Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacology Mice Mice, Inbred NOD Molecular Weight proteolysis therapeutics tissue repair Wound Healing - drug effects
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