Recurrent infection progressively disables host protection against intestinal inflammation

Intestinal inflammation is the central pathological feature of colitis and the inflammatory bowel diseases. These syndromes arise from unidentified environmental factors. We found that recurrent nonlethal gastric infections of Gram-negative Typhimurium (ST), a major source of human food poisoning, c...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-12, Vol.358 (6370), p.1588-1588
Hauptverfasser:	Yang, Won Ho, Heithoff, Douglas M., Aziz, Peter V., Sperandio, Markus, Nizet, Victor, Mahan, Michael J., Marth, Jamey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aging Alkaline phosphatase Animal tissues Augmentation Bacteria Bacterial infections Biodegradation Chronic infection Colon Crohn's Disease Diseases Disorders Duodenum Enterocytes Environmental factors Environmental Influences Exo-a-sialidase Food contamination Food contamination & poisoning Food poisoning Food production Food sources Foodborne diseases Human behavior Human populations Infections Inflammation Inflammatory bowel disease Inflammatory bowel diseases Ingestion Inhibition Inhibitors Life span Lipopolysaccharides Pathogens Phosphatase Phosphates Poisoning Recurrent infection RESEARCH ARTICLE SUMMARY Salmonella Salmonella enterica Salmonella Typhimurium Small intestine Substrates TLR4 protein Toll-like receptors Ulcerative colitis Zanamivir
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