The NAD + -Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning

Sirtuins are an evolutionarily conserved family of NAD -dependent lysine deacylases and ADP ribosylases. Their requirement for NAD as a cosubstrate allows them to act as metabolic sensors that couple changes in the energy status of the cell to changes in cellular physiological processes. NAD levels...

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Veröffentlicht in:	Antioxidants & redox signaling 2018-03, Vol.28 (8), p.691-710
Hauptverfasser:	Khoury, Nathalie, Koronowski, Kevin B, Young, Juan I, Perez-Pinzon, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Brain Brain - metabolism Brain - pathology Brain injury Brain Ischemia - genetics Brain Ischemia - metabolism Brain Ischemia - pathology Cell death Energy balance Forum Review Humans Intracellular levels Ischemia Lysine Metabolic disorders Metabolism Modulators NAD NAD - metabolism Neuromodulation Neuroprotection Oxidation-Reduction Pharmacology Preconditioning Proteins Sirtuins Sirtuins - genetics
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