Therapeutic potential of berberine against neurodegenerative diseases
Berberine （BBR） is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 dia...
Gespeichert in:
| Veröffentlicht in: | Science China. Life sciences 2015-06, Vol.58 (6), p.564-569 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 569 |
|---|---|
| container_issue | 6 |
| container_start_page | 564 |
| container_title | Science China. Life sciences |
| container_volume | 58 |
| creator | Jiang, WenXiao Li, ShiHua Li, XiaoJiang |
| description | Berberine （BBR） is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR＇s effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer＇s disease （AD） progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson＇s disease （PD）, and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases. |
| doi_str_mv | 10.1007/s11427-015-4829-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5823536</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>664995366</cqvip_id><sourcerecordid>3719727341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c596t-a1d15f20db7821ad058992c486ffc43983b6b44405ecf2f23ffbac0b593443a53</originalsourceid><addsrcrecordid>eNqFkUuLFDEUhYMozjDOD3AjhW7clOb92AgyjA8YcDOuQyp1U52hOulJqgbm35um22Z0oSGQwP3Oyc09CL0m-APBWH2shHCqekxEzzU1PX6GzomWpidam-ftLhXvFcPiDF3WeofbYgxTpV6iMyoUN5yyc3R9u4HidrAu0Xe7vEBaopu7HLoBStsxQecmF1NdugRrySNMkJpkiQ_QjbGCq1BfoRfBzRUuj-cF-vnl-vbqW3_z4-v3q883vRdGLr0jIxGB4nFQmhI3YqGNoZ5rGYLnzGg2yIFzjgX4QANlIQzO40EYxjlzgl2gTwff3TpsYfSt2-Jmuytx68qjzS7aPyspbuyUH6zQlAkmm8H7o0HJ9yvUxW5j9TDPLkFeqyUKmzZEQtX_UWkwJVJQ09B3f6F3eS2pTaJR2mgsGd5T5ED5kmstEE59E2z3kdpDpLZFaveRWtw0b55--KT4HWAD6AGorZQmKE-e_ofr22Mnm5ym-6Y7GUvJjWmTkuwXzga3kg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1689806309</pqid></control><display><type>article</type><title>Therapeutic potential of berberine against neurodegenerative diseases</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Alma/SFX Local Collection</source><creator>Jiang, WenXiao ; Li, ShiHua ; Li, XiaoJiang</creator><creatorcontrib>Jiang, WenXiao ; Li, ShiHua ; Li, XiaoJiang</creatorcontrib><description>Berberine （BBR） is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR＇s effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer＇s disease （AD） progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson＇s disease （PD）, and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><identifier>DOI: 10.1007/s11427-015-4829-0</identifier><identifier>PMID: 25749423</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Alzheimer Disease - prevention & control ; Animals ; BBR ; Berberine - therapeutic use ; Biomedical and Life Sciences ; Blood-Brain Barrier ; Disease Models, Animal ; Humans ; Life Sciences ; Medicine, Chinese Traditional ; Mice ; Models, Biological ; Neurodegenerative Diseases - prevention & control ; Neurons - pathology ; Parkinson Disease - prevention & control ; Review ; 治疗 ; 神经变性疾病 ; 神经退行性疾病 ; 防御能力 ; 阿尔茨海默氏病 ; 高胆固醇血症 ; 黄连素</subject><ispartof>Science China. Life sciences, 2015-06, Vol.58 (6), p.564-569</ispartof><rights>The Author(s) 2015</rights><rights>Science in China Press and Springer-Verlag GmbH 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-a1d15f20db7821ad058992c486ffc43983b6b44405ecf2f23ffbac0b593443a53</citedby><cites>FETCH-LOGICAL-c596t-a1d15f20db7821ad058992c486ffc43983b6b44405ecf2f23ffbac0b593443a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60112X/60112X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11427-015-4829-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11427-015-4829-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25749423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, WenXiao</creatorcontrib><creatorcontrib>Li, ShiHua</creatorcontrib><creatorcontrib>Li, XiaoJiang</creatorcontrib><title>Therapeutic potential of berberine against neurodegenerative diseases</title><title>Science China. Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>Berberine （BBR） is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR＇s effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer＇s disease （AD） progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson＇s disease （PD）, and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.</description><subject>Alzheimer Disease - prevention & control</subject><subject>Animals</subject><subject>BBR</subject><subject>Berberine - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Blood-Brain Barrier</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Medicine, Chinese Traditional</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Neurodegenerative Diseases - prevention & control</subject><subject>Neurons - pathology</subject><subject>Parkinson Disease - prevention & control</subject><subject>Review</subject><subject>治疗</subject><subject>神经变性疾病</subject><subject>神经退行性疾病</subject><subject>防御能力</subject><subject>阿尔茨海默氏病</subject><subject>高胆固醇血症</subject><subject>黄连素</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUuLFDEUhYMozjDOD3AjhW7clOb92AgyjA8YcDOuQyp1U52hOulJqgbm35um22Z0oSGQwP3Oyc09CL0m-APBWH2shHCqekxEzzU1PX6GzomWpidam-ftLhXvFcPiDF3WeofbYgxTpV6iMyoUN5yyc3R9u4HidrAu0Xe7vEBaopu7HLoBStsxQecmF1NdugRrySNMkJpkiQ_QjbGCq1BfoRfBzRUuj-cF-vnl-vbqW3_z4-v3q883vRdGLr0jIxGB4nFQmhI3YqGNoZ5rGYLnzGg2yIFzjgX4QANlIQzO40EYxjlzgl2gTwff3TpsYfSt2-Jmuytx68qjzS7aPyspbuyUH6zQlAkmm8H7o0HJ9yvUxW5j9TDPLkFeqyUKmzZEQtX_UWkwJVJQ09B3f6F3eS2pTaJR2mgsGd5T5ED5kmstEE59E2z3kdpDpLZFaveRWtw0b55--KT4HWAD6AGorZQmKE-e_ofr22Mnm5ym-6Y7GUvJjWmTkuwXzga3kg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Jiang, WenXiao</creator><creator>Li, ShiHua</creator><creator>Li, XiaoJiang</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Therapeutic potential of berberine against neurodegenerative diseases</title><author>Jiang, WenXiao ; Li, ShiHua ; Li, XiaoJiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-a1d15f20db7821ad058992c486ffc43983b6b44405ecf2f23ffbac0b593443a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alzheimer Disease - prevention & control</topic><topic>Animals</topic><topic>BBR</topic><topic>Berberine - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Blood-Brain Barrier</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Medicine, Chinese Traditional</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Neurodegenerative Diseases - prevention & control</topic><topic>Neurons - pathology</topic><topic>Parkinson Disease - prevention & control</topic><topic>Review</topic><topic>治疗</topic><topic>神经变性疾病</topic><topic>神经退行性疾病</topic><topic>防御能力</topic><topic>阿尔茨海默氏病</topic><topic>高胆固醇血症</topic><topic>黄连素</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, WenXiao</creatorcontrib><creatorcontrib>Li, ShiHua</creatorcontrib><creatorcontrib>Li, XiaoJiang</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science China. Life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, WenXiao</au><au>Li, ShiHua</au><au>Li, XiaoJiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic potential of berberine against neurodegenerative diseases</atitle><jtitle>Science China. Life sciences</jtitle><stitle>Sci. China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>58</volume><issue>6</issue><spage>564</spage><epage>569</epage><pages>564-569</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>Berberine （BBR） is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR＇s effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer＇s disease （AD） progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson＇s disease （PD）, and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>25749423</pmid><doi>10.1007/s11427-015-4829-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1674-7305 |
| ispartof | Science China. Life sciences, 2015-06, Vol.58 (6), p.564-569 |
| issn | 1674-7305 1869-1889 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5823536 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | Alzheimer Disease - prevention & control Animals BBR Berberine - therapeutic use Biomedical and Life Sciences Blood-Brain Barrier Disease Models, Animal Humans Life Sciences Medicine, Chinese Traditional Mice Models, Biological Neurodegenerative Diseases - prevention & control Neurons - pathology Parkinson Disease - prevention & control Review 治疗 神经变性疾病 神经退行性疾病 防御能力 阿尔茨海默氏病 高胆固醇血症 黄连素 |
| title | Therapeutic potential of berberine against neurodegenerative diseases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T14%3A50%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Therapeutic%20potential%20of%20berberine%20against%20neurodegenerative%20diseases&rft.jtitle=Science%20China.%20Life%20sciences&rft.au=Jiang,%20WenXiao&rft.date=2015-06-01&rft.volume=58&rft.issue=6&rft.spage=564&rft.epage=569&rft.pages=564-569&rft.issn=1674-7305&rft.eissn=1869-1889&rft_id=info:doi/10.1007/s11427-015-4829-0&rft_dat=%3Cproquest_pubme%3E3719727341%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1689806309&rft_id=info:pmid/25749423&rft_cqvip_id=664995366&rfr_iscdi=true |