Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis
Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis. ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine. This study investigated the...
Gespeichert in:
| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-11 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11 |
|---|---|
| container_issue | 2018 |
| container_start_page | 1 |
| container_title | Evidence-based complementary and alternative medicine |
| container_volume | 2018 |
| creator | Kim, Seonjong Kim, Youg Ran Kim, Tae-Gwang Won, Jeong-Yoon Choi, Chan-Hun Jeong, Ji-Won Bae, Kil-Joon Na, Changsu |
| description | Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis. ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine. This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis. Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group. Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed. Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured. ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity. Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels. This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model. These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis. However, further studies are required to elucidate the corresponding mechanisms. |
| doi_str_mv | 10.1155/2018/8565132 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5822925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A604313376</galeid><sourcerecordid>A604313376</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-43c966522b75e263658c5a55e170be3110d748b6a53c4efe2af86bda206ba4e3</originalsourceid><addsrcrecordid>eNqNkc9rFDEUxwdRbK3ePMuAF0HH5sfkx1yEZam60FKQPXgLmeSlmzKb1CSj-N-bdddt9eQpD96Hz8t736Z5idF7jBk7JwjLc8k4w5Q8ak6x6HHXEykfH2vx9aR5lvMtQmQQQjxtTsjABJeInDZuEYqPuUDUqWySL960F86BKbmNrl1uYrAprlsfWt1-0aW9ihamXesqhpij9fO2XUUbtYGiC3SrYGcDtr1-6MzPmydOTxleHN6zZv3xYr383F1ef1otF5ed6YehdD01A-eMkFEwIJxyJg3TjAEWaASKMbKilyPXjJoeHBDtJB-tJoiPugd61nzYa-_mcQvWQChJT-ou-a1OP1XUXv3dCX6jbuJ3xSQhA2FV8OYgSPHbDLmorc8GpkkHiHNWu2NzzgWjFX39D3ob5xTqdpWqlyYS9eieutETKB9crHPNTqoWHPUUUyp4pd7tKZNizgnc8csYqV3KvwerQ8oVf_VwzSP8J9YKvN0DGx-s_uH_UweVAafvacw4x5z-ArWUuOc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2002928040</pqid></control><display><type>article</type><title>Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis</title><source>Wiley-Blackwell Open Access Titles</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Kim, Seonjong ; Kim, Youg Ran ; Kim, Tae-Gwang ; Won, Jeong-Yoon ; Choi, Chan-Hun ; Jeong, Ji-Won ; Bae, Kil-Joon ; Na, Changsu</creator><contributor>Kraft, Karin</contributor><creatorcontrib>Kim, Seonjong ; Kim, Youg Ran ; Kim, Tae-Gwang ; Won, Jeong-Yoon ; Choi, Chan-Hun ; Jeong, Ji-Won ; Bae, Kil-Joon ; Na, Changsu ; Kraft, Karin</creatorcontrib><description>Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis. ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine. This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis. Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group. Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed. Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured. ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity. Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels. This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model. These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis. However, further studies are required to elucidate the corresponding mechanisms.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/8565132</identifier><identifier>PMID: 29576802</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alanine ; Alanine transaminase ; Analgesics ; Angelica gigas ; Antiarthritic agents ; Aspartate aminotransferase ; Cartilage (articular) ; Cartilage diseases ; Clematis ; Cytokines ; Edema ; Fever ; Hematology ; Herbal medicine ; Histochemistry ; Histopathology ; Hospitals ; Inflammation ; Interleukin 1 ; Interleukin 6 ; Interleukins ; Liver ; Lonicera japonica ; Medical research ; Medicine ; Medicine, Botanic ; Medicine, Herbal ; Osteoarthritis ; Pain ; Phellodendron amurense ; Prostaglandin E2 ; Prostaglandins E ; Rats ; Reaction time task ; Rehabilitation ; Rheumatoid arthritis ; Rodents ; Serum levels ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Umbelliferae</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-11</ispartof><rights>Copyright © 2018 Kil-Joon Bae et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Kil-Joon Bae et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Kil-Joon Bae et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-43c966522b75e263658c5a55e170be3110d748b6a53c4efe2af86bda206ba4e3</citedby><cites>FETCH-LOGICAL-c499t-43c966522b75e263658c5a55e170be3110d748b6a53c4efe2af86bda206ba4e3</cites><orcidid>0000-0001-5478-649X ; 0000-0002-0346-8288 ; 0000-0001-9033-9021 ; 0000-0002-8686-4955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822925/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29576802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kraft, Karin</contributor><creatorcontrib>Kim, Seonjong</creatorcontrib><creatorcontrib>Kim, Youg Ran</creatorcontrib><creatorcontrib>Kim, Tae-Gwang</creatorcontrib><creatorcontrib>Won, Jeong-Yoon</creatorcontrib><creatorcontrib>Choi, Chan-Hun</creatorcontrib><creatorcontrib>Jeong, Ji-Won</creatorcontrib><creatorcontrib>Bae, Kil-Joon</creatorcontrib><creatorcontrib>Na, Changsu</creatorcontrib><title>Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis. ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine. This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis. Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group. Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed. Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured. ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity. Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels. This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model. These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis. However, further studies are required to elucidate the corresponding mechanisms.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Analgesics</subject><subject>Angelica gigas</subject><subject>Antiarthritic agents</subject><subject>Aspartate aminotransferase</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Clematis</subject><subject>Cytokines</subject><subject>Edema</subject><subject>Fever</subject><subject>Hematology</subject><subject>Herbal medicine</subject><subject>Histochemistry</subject><subject>Histopathology</subject><subject>Hospitals</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Liver</subject><subject>Lonicera japonica</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Osteoarthritis</subject><subject>Pain</subject><subject>Phellodendron amurense</subject><subject>Prostaglandin E2</subject><subject>Prostaglandins E</subject><subject>Rats</subject><subject>Reaction time task</subject><subject>Rehabilitation</subject><subject>Rheumatoid arthritis</subject><subject>Rodents</subject><subject>Serum levels</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Umbelliferae</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc9rFDEUxwdRbK3ePMuAF0HH5sfkx1yEZam60FKQPXgLmeSlmzKb1CSj-N-bdddt9eQpD96Hz8t736Z5idF7jBk7JwjLc8k4w5Q8ak6x6HHXEykfH2vx9aR5lvMtQmQQQjxtTsjABJeInDZuEYqPuUDUqWySL960F86BKbmNrl1uYrAprlsfWt1-0aW9ihamXesqhpij9fO2XUUbtYGiC3SrYGcDtr1-6MzPmydOTxleHN6zZv3xYr383F1ef1otF5ed6YehdD01A-eMkFEwIJxyJg3TjAEWaASKMbKilyPXjJoeHBDtJB-tJoiPugd61nzYa-_mcQvWQChJT-ou-a1OP1XUXv3dCX6jbuJ3xSQhA2FV8OYgSPHbDLmorc8GpkkHiHNWu2NzzgWjFX39D3ob5xTqdpWqlyYS9eieutETKB9crHPNTqoWHPUUUyp4pd7tKZNizgnc8csYqV3KvwerQ8oVf_VwzSP8J9YKvN0DGx-s_uH_UweVAafvacw4x5z-ArWUuOc</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Kim, Seonjong</creator><creator>Kim, Youg Ran</creator><creator>Kim, Tae-Gwang</creator><creator>Won, Jeong-Yoon</creator><creator>Choi, Chan-Hun</creator><creator>Jeong, Ji-Won</creator><creator>Bae, Kil-Joon</creator><creator>Na, Changsu</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5478-649X</orcidid><orcidid>https://orcid.org/0000-0002-0346-8288</orcidid><orcidid>https://orcid.org/0000-0001-9033-9021</orcidid><orcidid>https://orcid.org/0000-0002-8686-4955</orcidid></search><sort><creationdate>20180101</creationdate><title>Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis</title><author>Kim, Seonjong ; Kim, Youg Ran ; Kim, Tae-Gwang ; Won, Jeong-Yoon ; Choi, Chan-Hun ; Jeong, Ji-Won ; Bae, Kil-Joon ; Na, Changsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-43c966522b75e263658c5a55e170be3110d748b6a53c4efe2af86bda206ba4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Analgesics</topic><topic>Angelica gigas</topic><topic>Antiarthritic agents</topic><topic>Aspartate aminotransferase</topic><topic>Cartilage (articular)</topic><topic>Cartilage diseases</topic><topic>Clematis</topic><topic>Cytokines</topic><topic>Edema</topic><topic>Fever</topic><topic>Hematology</topic><topic>Herbal medicine</topic><topic>Histochemistry</topic><topic>Histopathology</topic><topic>Hospitals</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Liver</topic><topic>Lonicera japonica</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Osteoarthritis</topic><topic>Pain</topic><topic>Phellodendron amurense</topic><topic>Prostaglandin E2</topic><topic>Prostaglandins E</topic><topic>Rats</topic><topic>Reaction time task</topic><topic>Rehabilitation</topic><topic>Rheumatoid arthritis</topic><topic>Rodents</topic><topic>Serum levels</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Umbelliferae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seonjong</creatorcontrib><creatorcontrib>Kim, Youg Ran</creatorcontrib><creatorcontrib>Kim, Tae-Gwang</creatorcontrib><creatorcontrib>Won, Jeong-Yoon</creatorcontrib><creatorcontrib>Choi, Chan-Hun</creatorcontrib><creatorcontrib>Jeong, Ji-Won</creatorcontrib><creatorcontrib>Bae, Kil-Joon</creatorcontrib><creatorcontrib>Na, Changsu</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seonjong</au><au>Kim, Youg Ran</au><au>Kim, Tae-Gwang</au><au>Won, Jeong-Yoon</au><au>Choi, Chan-Hun</au><au>Jeong, Ji-Won</au><au>Bae, Kil-Joon</au><au>Na, Changsu</au><au>Kraft, Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis. ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine. This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis. Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group. Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed. Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured. ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity. Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels. This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model. These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis. However, further studies are required to elucidate the corresponding mechanisms.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29576802</pmid><doi>10.1155/2018/8565132</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5478-649X</orcidid><orcidid>https://orcid.org/0000-0002-0346-8288</orcidid><orcidid>https://orcid.org/0000-0001-9033-9021</orcidid><orcidid>https://orcid.org/0000-0002-8686-4955</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-11 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5822925 |
| source | Wiley-Blackwell Open Access Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Alanine Alanine transaminase Analgesics Angelica gigas Antiarthritic agents Aspartate aminotransferase Cartilage (articular) Cartilage diseases Clematis Cytokines Edema Fever Hematology Herbal medicine Histochemistry Histopathology Hospitals Inflammation Interleukin 1 Interleukin 6 Interleukins Liver Lonicera japonica Medical research Medicine Medicine, Botanic Medicine, Herbal Osteoarthritis Pain Phellodendron amurense Prostaglandin E2 Prostaglandins E Rats Reaction time task Rehabilitation Rheumatoid arthritis Rodents Serum levels Tumor necrosis factor-TNF Tumor necrosis factor-α Umbelliferae |
| title | Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T18%3A39%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antiosteoarthritic%20Effects%20of%20ChondroT%20in%20a%20Rat%20Model%20of%20Monosodium%20Iodoacetate-Induced%20Osteoarthritis&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Kim,%20Seonjong&rft.date=2018-01-01&rft.volume=2018&rft.issue=2018&rft.spage=1&rft.epage=11&rft.pages=1-11&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2018/8565132&rft_dat=%3Cgale_pubme%3EA604313376%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2002928040&rft_id=info:pmid/29576802&rft_galeid=A604313376&rfr_iscdi=true |