Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis
To establish infection, pathogens secrete virulence factors, such as protein kinases and phosphatases, to modulate the signal transduction pathways used by host cells to initiate immune response. The protein MAP3893c is annotated in the genome sequence of Mycobacterium avium subspecies paratuberculo...
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| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-9 |
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| creator | Begg, Douglas J. Lai, Wanika Chaffer, Marcelo Bach, Eviatar Richard-Greenblatt, Melissa Bach, Horacio Keefe, Greg |
| description | To establish infection, pathogens secrete virulence factors, such as protein kinases and phosphatases, to modulate the signal transduction pathways used by host cells to initiate immune response. The protein MAP3893c is annotated in the genome sequence of Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne’s disease, as the serine/threonine protein kinase G (PknG). In this work, we report that PknG is a functional kinase that is secreted within macrophages at early stages of infection. The antigen is able to induce an immune response from cattle exposed to MAP in the form of interferon gamma production after stimulation of whole blood with PknG. These findings suggest that PknG may contribute to the pathogenesis of MAP by phosphorylating macrophage signalling and/or adaptor molecules as observed with other pathogenic mycobacterial species. |
| doi_str_mv | 10.1155/2018/1450828 |
| format | Article |
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The protein MAP3893c is annotated in the genome sequence of Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne’s disease, as the serine/threonine protein kinase G (PknG). In this work, we report that PknG is a functional kinase that is secreted within macrophages at early stages of infection. The antigen is able to induce an immune response from cattle exposed to MAP in the form of interferon gamma production after stimulation of whole blood with PknG. These findings suggest that PknG may contribute to the pathogenesis of MAP by phosphorylating macrophage signalling and/or adaptor molecules as observed with other pathogenic mycobacterial species.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/1450828</identifier><identifier>PMID: 29581962</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Bacterial Proteins - immunology ; BCG ; BCG vaccines ; Biological response modifiers ; Bovidae ; Cattle ; Cattle Diseases - immunology ; Cattle Diseases - pathology ; Cellular signal transduction ; Cyclic GMP-Dependent Protein Kinases - immunology ; Dairy industry ; Disease ; E coli ; Gene expression ; Genomes ; Genomics ; Health aspects ; Humans ; Immune response ; Immune system ; Immunology ; Infection ; Infections ; Interferon ; Johne's disease ; Kinases ; Macrophages ; Macrophages - immunology ; Macrophages - pathology ; Mycobacterium avium ; Mycobacterium avium subsp. paratuberculosis - immunology ; Mycobacterium avium subsp. paratuberculosis - pathogenicity ; Mycobacterium tuberculosis ; Nucleotide sequence ; Paratuberculosis ; Paratuberculosis - immunology ; Paratuberculosis - pathology ; Pathogenesis ; Penicillin ; Phosphatases ; Protein kinase ; Protein kinase G ; Protein kinases ; Protein-serine/threonine kinase ; Proteins ; Signal transduction ; Signaling ; Stem cells ; THP-1 Cells ; Tuberculosis ; Virulence ; Virulence (Microbiology) ; Virulence factors</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-9</ispartof><rights>Copyright © 2018 Horacio Bach et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Horacio Bach et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Horacio Bach et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-1ef7b8561f859e9bca7e16eff95aada91cf07ec0cb6831d8e10948c9e3e299833</citedby><cites>FETCH-LOGICAL-c461t-1ef7b8561f859e9bca7e16eff95aada91cf07ec0cb6831d8e10948c9e3e299833</cites><orcidid>0000-0002-7740-9299 ; 0000-0001-6717-8856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822771/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822771/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29581962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bogdanos, Dimitrios P.</contributor><contributor>Dimitrios P Bogdanos</contributor><creatorcontrib>Begg, Douglas J.</creatorcontrib><creatorcontrib>Lai, Wanika</creatorcontrib><creatorcontrib>Chaffer, Marcelo</creatorcontrib><creatorcontrib>Bach, Eviatar</creatorcontrib><creatorcontrib>Richard-Greenblatt, Melissa</creatorcontrib><creatorcontrib>Bach, Horacio</creatorcontrib><creatorcontrib>Keefe, Greg</creatorcontrib><title>Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>To establish infection, pathogens secrete virulence factors, such as protein kinases and phosphatases, to modulate the signal transduction pathways used by host cells to initiate immune response. The protein MAP3893c is annotated in the genome sequence of Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne’s disease, as the serine/threonine protein kinase G (PknG). In this work, we report that PknG is a functional kinase that is secreted within macrophages at early stages of infection. The antigen is able to induce an immune response from cattle exposed to MAP in the form of interferon gamma production after stimulation of whole blood with PknG. These findings suggest that PknG may contribute to the pathogenesis of MAP by phosphorylating macrophage signalling and/or adaptor molecules as observed with other pathogenic mycobacterial species.</description><subject>Animals</subject><subject>Bacterial Proteins - immunology</subject><subject>BCG</subject><subject>BCG vaccines</subject><subject>Biological response modifiers</subject><subject>Bovidae</subject><subject>Cattle</subject><subject>Cattle Diseases - immunology</subject><subject>Cattle Diseases - pathology</subject><subject>Cellular signal transduction</subject><subject>Cyclic GMP-Dependent Protein Kinases - immunology</subject><subject>Dairy industry</subject><subject>Disease</subject><subject>E coli</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infection</subject><subject>Infections</subject><subject>Interferon</subject><subject>Johne's disease</subject><subject>Kinases</subject><subject>Macrophages</subject><subject>Macrophages - 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immunology</topic><topic>BCG</topic><topic>BCG vaccines</topic><topic>Biological response modifiers</topic><topic>Bovidae</topic><topic>Cattle</topic><topic>Cattle Diseases - immunology</topic><topic>Cattle Diseases - pathology</topic><topic>Cellular signal transduction</topic><topic>Cyclic GMP-Dependent Protein Kinases - immunology</topic><topic>Dairy industry</topic><topic>Disease</topic><topic>E coli</topic><topic>Gene expression</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infection</topic><topic>Infections</topic><topic>Interferon</topic><topic>Johne's disease</topic><topic>Kinases</topic><topic>Macrophages</topic><topic>Macrophages - immunology</topic><topic>Macrophages - pathology</topic><topic>Mycobacterium avium</topic><topic>Mycobacterium avium subsp. paratuberculosis - immunology</topic><topic>Mycobacterium avium subsp. paratuberculosis - pathogenicity</topic><topic>Mycobacterium tuberculosis</topic><topic>Nucleotide sequence</topic><topic>Paratuberculosis</topic><topic>Paratuberculosis - immunology</topic><topic>Paratuberculosis - pathology</topic><topic>Pathogenesis</topic><topic>Penicillin</topic><topic>Phosphatases</topic><topic>Protein kinase</topic><topic>Protein kinase G</topic><topic>Protein kinases</topic><topic>Protein-serine/threonine kinase</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Stem cells</topic><topic>THP-1 Cells</topic><topic>Tuberculosis</topic><topic>Virulence</topic><topic>Virulence (Microbiology)</topic><topic>Virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begg, Douglas J.</creatorcontrib><creatorcontrib>Lai, Wanika</creatorcontrib><creatorcontrib>Chaffer, Marcelo</creatorcontrib><creatorcontrib>Bach, Eviatar</creatorcontrib><creatorcontrib>Richard-Greenblatt, Melissa</creatorcontrib><creatorcontrib>Bach, Horacio</creatorcontrib><creatorcontrib>Keefe, Greg</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begg, Douglas J.</au><au>Lai, Wanika</au><au>Chaffer, Marcelo</au><au>Bach, Eviatar</au><au>Richard-Greenblatt, Melissa</au><au>Bach, Horacio</au><au>Keefe, Greg</au><au>Bogdanos, Dimitrios P.</au><au>Dimitrios P Bogdanos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>To establish infection, pathogens secrete virulence factors, such as protein kinases and phosphatases, to modulate the signal transduction pathways used by host cells to initiate immune response. The protein MAP3893c is annotated in the genome sequence of Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne’s disease, as the serine/threonine protein kinase G (PknG). In this work, we report that PknG is a functional kinase that is secreted within macrophages at early stages of infection. The antigen is able to induce an immune response from cattle exposed to MAP in the form of interferon gamma production after stimulation of whole blood with PknG. These findings suggest that PknG may contribute to the pathogenesis of MAP by phosphorylating macrophage signalling and/or adaptor molecules as observed with other pathogenic mycobacterial species.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29581962</pmid><doi>10.1155/2018/1450828</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7740-9299</orcidid><orcidid>https://orcid.org/0000-0001-6717-8856</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bacterial Proteins - immunology BCG BCG vaccines Biological response modifiers Bovidae Cattle Cattle Diseases - immunology Cattle Diseases - pathology Cellular signal transduction Cyclic GMP-Dependent Protein Kinases - immunology Dairy industry Disease E coli Gene expression Genomes Genomics Health aspects Humans Immune response Immune system Immunology Infection Infections Interferon Johne's disease Kinases Macrophages Macrophages - immunology Macrophages - pathology Mycobacterium avium Mycobacterium avium subsp. paratuberculosis - immunology Mycobacterium avium subsp. paratuberculosis - pathogenicity Mycobacterium tuberculosis Nucleotide sequence Paratuberculosis Paratuberculosis - immunology Paratuberculosis - pathology Pathogenesis Penicillin Phosphatases Protein kinase Protein kinase G Protein kinases Protein-serine/threonine kinase Proteins Signal transduction Signaling Stem cells THP-1 Cells Tuberculosis Virulence Virulence (Microbiology) Virulence factors |
| title | Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis |
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