GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons

Human mutations of the GRID1 gene encoding the orphan delta1 glutamate receptor-channel (GluD1) are associated with schizophrenia but the explicit role of GluD1 in brain circuits is unknown. Based on the known function of its paralog GluD2 in cerebellum, we searched for a role of GluD1 in slow gluta...

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Veröffentlicht in:	Molecular psychiatry 2018-03, Vol.23 (3), p.691-700
Hauptverfasser:	Benamer, N, Marti, F, Lujan, R, Hepp, R, Aubier, T G, Dupin, A A M, Frébourg, G, Pons, S, Maskos, U, Faure, P, Hay, Y A, Lambolez, B, Tricoire, L
Format:	Artikel
Sprache:	eng
Schlagworte:	13/44 13/51 631/378 631/443 64/110 9/74 Animals Behavioral Sciences Biological Psychology Brain slice preparation Cerebellum Cerebellum - metabolism Depolarization Dopamine Dopamine - metabolism Dopamine receptors Dopaminergic Neurons - metabolism Dopaminergic Neurons - physiology Gene mutation Genetic aspects Glutamate Dehydrogenase - genetics Glutamate Dehydrogenase - physiology Glutamatergic transmission Glutamic acid receptors (metabotropic) Health aspects HEK293 Cells Humans Ion channels Life Sciences Medicine Medicine & Public Health Mental disorders Mesencephalon Metabotropic receptors Mice Mice, Inbred C57BL Mice, Knockout Mutation Neural circuitry Neurobiology Neurons Neurons and Cognition Neurosciences Original original-article Pharmacotherapy Psychiatry Psychological aspects Receptors, Glutamate - genetics Receptors, Glutamate - physiology Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Reinforcement Risk factors Rodents Schizophrenia Schizophrenia - genetics Single-Cell Analysis
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