Association Between Migraine and Cervical Artery Dissection: The Italian Project on Stroke in Young Adults
IMPORTANCE: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditi...
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| Veröffentlicht in: | JAMA neurology 2017-05, Vol.74 (5), p.512-518 |
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| creator | De Giuli, Valeria Grassi, Mario Lodigiani, Corrado Patella, Rosalba Zedde, Marialuisa Gandolfo, Carlo Zini, Andrea DeLodovici, Maria Luisa Paciaroni, Maurizio Del Sette, Massimo Azzini, Cristiano Toriello, Antonella Musolino, Rossella Calabrò, Rocco Salvatore Bovi, Paolo Sessa, Maria Adami, Alessandro Silvestrelli, Giorgio Cavallini, Anna Marcheselli, Simona Bonifati, Domenico Marco Checcarelli, Nicoletta Tancredi, Lucia Chiti, Alberto Lotti, Enrico Maria Del Zotto, Elisabetta Tomelleri, Giampaolo Spalloni, Alessandra Giorli, Elisa Costa, Paolo Poli, Loris Morotti, Andrea Caria, Filomena Lanari, Alessia Giacalone, Giacomo Ferrazzi, Paola Giossi, Alessia Piras, Valeria Massucco, Davide D’Amore, Cataldo Di Lisi, Filomena Casetta, Ilaria Cucurachi, Laura Cotroneo, Masina De Vito, Alessandro Coloberti, Elisa Rasura, Maurizia Simone, Anna Maria Gamba, Massimo Cerrato, Paolo Micieli, Giuseppe Malferrari, Giovanni Melis, Maurizio Iacoviello, Licia Padovani, Alessandro Pezzini, Alessandro |
| description | IMPORTANCE: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). OBJECTIVE: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of consecutive patients aged 18 to 45 years with first-ever acute ischemic stroke enrolled in the multicenter Italian Project on Stroke in Young Adults was conducted between January 1, 2000, and June 30, 2015. In a case-control design, the study assessed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs between patients whose IS was due to CEAD (CEAD IS) and those whose IS was due to a cause other than CEAD (non-CEAD IS) and compared the characteristics of patients with CEAD IS with and without migraine. MAIN OUTCOMES AND MEASURES: Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS. RESULTS: Of the 2485 patients (mean [SD] age, 36.8 [7.1] years; women, 1163 [46.8%]) included in the registry, 334 (13.4%) had CEAD IS and 2151 (86.6%) had non-CEAD IS. Migraine was more common in the CEAD IS group (103 [30.8%] vs 525 [24.4%], P = .01), and the difference was mainly due to migraine without aura (80 [24.0%] vs 335 [15.6%], P .99). CONCLUSIONS AND RELEVANCE: In patients with IS aged 18 to 45 years, migraine, especially migraine without aura, is consistently associated with CEAD. This finding suggests common features and warrants further analyses to elucidate the underlying biologic mechanisms. |
| doi_str_mv | 10.1001/jamaneurol.2016.5704 |
| format | Article |
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This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). OBJECTIVE: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of consecutive patients aged 18 to 45 years with first-ever acute ischemic stroke enrolled in the multicenter Italian Project on Stroke in Young Adults was conducted between January 1, 2000, and June 30, 2015. In a case-control design, the study assessed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs between patients whose IS was due to CEAD (CEAD IS) and those whose IS was due to a cause other than CEAD (non-CEAD IS) and compared the characteristics of patients with CEAD IS with and without migraine. MAIN OUTCOMES AND MEASURES: Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS. RESULTS: Of the 2485 patients (mean [SD] age, 36.8 [7.1] years; women, 1163 [46.8%]) included in the registry, 334 (13.4%) had CEAD IS and 2151 (86.6%) had non-CEAD IS. Migraine was more common in the CEAD IS group (103 [30.8%] vs 525 [24.4%], P = .01), and the difference was mainly due to migraine without aura (80 [24.0%] vs 335 [15.6%], P < .001). Compared with migraine with aura, migraine without aura was independently associated with CEAD IS (OR, 1.74; 95% CI, 1.30-2.33). The strength of this association was higher in men (OR, 1.99; 95% CI, 1.31-3.04) and in patients 39.0 years or younger (OR, 1.82; 95% CI, 1.22-2.71). The risk factor profile was similar in migrainous and non-migrainous patients with CEAD IS (eg, hypertension, 20 [19.4%] vs 57 [24.7%], P = .29; diabetes, 1 [1.0%] vs 3 [1.3%], P > .99). CONCLUSIONS AND RELEVANCE: In patients with IS aged 18 to 45 years, migraine, especially migraine without aura, is consistently associated with CEAD. This finding suggests common features and warrants further analyses to elucidate the underlying biologic mechanisms.</description><identifier>ISSN: 2168-6149</identifier><identifier>EISSN: 2168-6157</identifier><identifier>DOI: 10.1001/jamaneurol.2016.5704</identifier><identifier>PMID: 28264095</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adolescent ; Adult ; Age Factors ; Brain Ischemia - epidemiology ; Case-Control Studies ; Female ; Humans ; Intracranial Arterial Diseases - epidemiology ; Italy - epidemiology ; Male ; Middle Aged ; Migraine with Aura - epidemiology ; Migraine without Aura - epidemiology ; Online First ; Original Investigation ; Prospective Studies ; Registries ; Sex Factors ; Stroke - epidemiology ; Young Adult</subject><ispartof>JAMA neurology, 2017-05, Vol.74 (5), p.512-518</ispartof><rights>Copyright 2017 American Medical Association. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamaneurology/articlepdf/10.1001/jamaneurol.2016.5704$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2016.5704$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,230,314,776,780,881,3327,27901,27902,76232,76235</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28264095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Giuli, Valeria</creatorcontrib><creatorcontrib>Grassi, Mario</creatorcontrib><creatorcontrib>Lodigiani, Corrado</creatorcontrib><creatorcontrib>Patella, Rosalba</creatorcontrib><creatorcontrib>Zedde, Marialuisa</creatorcontrib><creatorcontrib>Gandolfo, Carlo</creatorcontrib><creatorcontrib>Zini, Andrea</creatorcontrib><creatorcontrib>DeLodovici, Maria Luisa</creatorcontrib><creatorcontrib>Paciaroni, Maurizio</creatorcontrib><creatorcontrib>Del Sette, Massimo</creatorcontrib><creatorcontrib>Azzini, Cristiano</creatorcontrib><creatorcontrib>Toriello, Antonella</creatorcontrib><creatorcontrib>Musolino, Rossella</creatorcontrib><creatorcontrib>Calabrò, Rocco Salvatore</creatorcontrib><creatorcontrib>Bovi, Paolo</creatorcontrib><creatorcontrib>Sessa, Maria</creatorcontrib><creatorcontrib>Adami, Alessandro</creatorcontrib><creatorcontrib>Silvestrelli, Giorgio</creatorcontrib><creatorcontrib>Cavallini, Anna</creatorcontrib><creatorcontrib>Marcheselli, Simona</creatorcontrib><creatorcontrib>Bonifati, Domenico Marco</creatorcontrib><creatorcontrib>Checcarelli, Nicoletta</creatorcontrib><creatorcontrib>Tancredi, Lucia</creatorcontrib><creatorcontrib>Chiti, Alberto</creatorcontrib><creatorcontrib>Lotti, Enrico Maria</creatorcontrib><creatorcontrib>Del Zotto, Elisabetta</creatorcontrib><creatorcontrib>Tomelleri, Giampaolo</creatorcontrib><creatorcontrib>Spalloni, Alessandra</creatorcontrib><creatorcontrib>Giorli, Elisa</creatorcontrib><creatorcontrib>Costa, Paolo</creatorcontrib><creatorcontrib>Poli, Loris</creatorcontrib><creatorcontrib>Morotti, Andrea</creatorcontrib><creatorcontrib>Caria, Filomena</creatorcontrib><creatorcontrib>Lanari, Alessia</creatorcontrib><creatorcontrib>Giacalone, Giacomo</creatorcontrib><creatorcontrib>Ferrazzi, Paola</creatorcontrib><creatorcontrib>Giossi, Alessia</creatorcontrib><creatorcontrib>Piras, Valeria</creatorcontrib><creatorcontrib>Massucco, Davide</creatorcontrib><creatorcontrib>D’Amore, Cataldo</creatorcontrib><creatorcontrib>Di Lisi, Filomena</creatorcontrib><creatorcontrib>Casetta, Ilaria</creatorcontrib><creatorcontrib>Cucurachi, Laura</creatorcontrib><creatorcontrib>Cotroneo, Masina</creatorcontrib><creatorcontrib>De Vito, Alessandro</creatorcontrib><creatorcontrib>Coloberti, Elisa</creatorcontrib><creatorcontrib>Rasura, Maurizia</creatorcontrib><creatorcontrib>Simone, Anna Maria</creatorcontrib><creatorcontrib>Gamba, Massimo</creatorcontrib><creatorcontrib>Cerrato, Paolo</creatorcontrib><creatorcontrib>Micieli, Giuseppe</creatorcontrib><creatorcontrib>Malferrari, Giovanni</creatorcontrib><creatorcontrib>Melis, Maurizio</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>Padovani, Alessandro</creatorcontrib><creatorcontrib>Pezzini, Alessandro</creatorcontrib><creatorcontrib>Italian Project on Stroke in Young Adults Investigators</creatorcontrib><creatorcontrib>for the Italian Project on Stroke in Young Adults Investigators</creatorcontrib><title>Association Between Migraine and Cervical Artery Dissection: The Italian Project on Stroke in Young Adults</title><title>JAMA neurology</title><addtitle>JAMA Neurol</addtitle><description>IMPORTANCE: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). OBJECTIVE: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of consecutive patients aged 18 to 45 years with first-ever acute ischemic stroke enrolled in the multicenter Italian Project on Stroke in Young Adults was conducted between January 1, 2000, and June 30, 2015. In a case-control design, the study assessed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs between patients whose IS was due to CEAD (CEAD IS) and those whose IS was due to a cause other than CEAD (non-CEAD IS) and compared the characteristics of patients with CEAD IS with and without migraine. MAIN OUTCOMES AND MEASURES: Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS. RESULTS: Of the 2485 patients (mean [SD] age, 36.8 [7.1] years; women, 1163 [46.8%]) included in the registry, 334 (13.4%) had CEAD IS and 2151 (86.6%) had non-CEAD IS. Migraine was more common in the CEAD IS group (103 [30.8%] vs 525 [24.4%], P = .01), and the difference was mainly due to migraine without aura (80 [24.0%] vs 335 [15.6%], P < .001). Compared with migraine with aura, migraine without aura was independently associated with CEAD IS (OR, 1.74; 95% CI, 1.30-2.33). The strength of this association was higher in men (OR, 1.99; 95% CI, 1.31-3.04) and in patients 39.0 years or younger (OR, 1.82; 95% CI, 1.22-2.71). The risk factor profile was similar in migrainous and non-migrainous patients with CEAD IS (eg, hypertension, 20 [19.4%] vs 57 [24.7%], P = .29; diabetes, 1 [1.0%] vs 3 [1.3%], P > .99). CONCLUSIONS AND RELEVANCE: In patients with IS aged 18 to 45 years, migraine, especially migraine without aura, is consistently associated with CEAD. This finding suggests common features and warrants further analyses to elucidate the underlying biologic mechanisms.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Brain Ischemia - epidemiology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Intracranial Arterial Diseases - epidemiology</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Migraine with Aura - epidemiology</subject><subject>Migraine without Aura - epidemiology</subject><subject>Online First</subject><subject>Original Investigation</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Sex Factors</subject><subject>Stroke - epidemiology</subject><subject>Young 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Diseases - epidemiology</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Migraine with Aura - epidemiology</topic><topic>Migraine without Aura - epidemiology</topic><topic>Online First</topic><topic>Original Investigation</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Sex Factors</topic><topic>Stroke - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Giuli, Valeria</creatorcontrib><creatorcontrib>Grassi, Mario</creatorcontrib><creatorcontrib>Lodigiani, Corrado</creatorcontrib><creatorcontrib>Patella, Rosalba</creatorcontrib><creatorcontrib>Zedde, Marialuisa</creatorcontrib><creatorcontrib>Gandolfo, Carlo</creatorcontrib><creatorcontrib>Zini, Andrea</creatorcontrib><creatorcontrib>DeLodovici, Maria Luisa</creatorcontrib><creatorcontrib>Paciaroni, Maurizio</creatorcontrib><creatorcontrib>Del Sette, Massimo</creatorcontrib><creatorcontrib>Azzini, Cristiano</creatorcontrib><creatorcontrib>Toriello, Antonella</creatorcontrib><creatorcontrib>Musolino, Rossella</creatorcontrib><creatorcontrib>Calabrò, Rocco Salvatore</creatorcontrib><creatorcontrib>Bovi, Paolo</creatorcontrib><creatorcontrib>Sessa, Maria</creatorcontrib><creatorcontrib>Adami, Alessandro</creatorcontrib><creatorcontrib>Silvestrelli, Giorgio</creatorcontrib><creatorcontrib>Cavallini, Anna</creatorcontrib><creatorcontrib>Marcheselli, Simona</creatorcontrib><creatorcontrib>Bonifati, Domenico Marco</creatorcontrib><creatorcontrib>Checcarelli, Nicoletta</creatorcontrib><creatorcontrib>Tancredi, Lucia</creatorcontrib><creatorcontrib>Chiti, Alberto</creatorcontrib><creatorcontrib>Lotti, Enrico Maria</creatorcontrib><creatorcontrib>Del Zotto, Elisabetta</creatorcontrib><creatorcontrib>Tomelleri, Giampaolo</creatorcontrib><creatorcontrib>Spalloni, Alessandra</creatorcontrib><creatorcontrib>Giorli, Elisa</creatorcontrib><creatorcontrib>Costa, Paolo</creatorcontrib><creatorcontrib>Poli, Loris</creatorcontrib><creatorcontrib>Morotti, Andrea</creatorcontrib><creatorcontrib>Caria, Filomena</creatorcontrib><creatorcontrib>Lanari, Alessia</creatorcontrib><creatorcontrib>Giacalone, Giacomo</creatorcontrib><creatorcontrib>Ferrazzi, Paola</creatorcontrib><creatorcontrib>Giossi, Alessia</creatorcontrib><creatorcontrib>Piras, Valeria</creatorcontrib><creatorcontrib>Massucco, Davide</creatorcontrib><creatorcontrib>D’Amore, Cataldo</creatorcontrib><creatorcontrib>Di Lisi, Filomena</creatorcontrib><creatorcontrib>Casetta, Ilaria</creatorcontrib><creatorcontrib>Cucurachi, Laura</creatorcontrib><creatorcontrib>Cotroneo, Masina</creatorcontrib><creatorcontrib>De Vito, Alessandro</creatorcontrib><creatorcontrib>Coloberti, Elisa</creatorcontrib><creatorcontrib>Rasura, Maurizia</creatorcontrib><creatorcontrib>Simone, Anna Maria</creatorcontrib><creatorcontrib>Gamba, Massimo</creatorcontrib><creatorcontrib>Cerrato, Paolo</creatorcontrib><creatorcontrib>Micieli, Giuseppe</creatorcontrib><creatorcontrib>Malferrari, Giovanni</creatorcontrib><creatorcontrib>Melis, Maurizio</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>Padovani, Alessandro</creatorcontrib><creatorcontrib>Pezzini, Alessandro</creatorcontrib><creatorcontrib>Italian Project on Stroke in Young Adults Investigators</creatorcontrib><creatorcontrib>for the Italian Project on Stroke in Young Adults Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Giuli, Valeria</au><au>Grassi, Mario</au><au>Lodigiani, Corrado</au><au>Patella, Rosalba</au><au>Zedde, Marialuisa</au><au>Gandolfo, Carlo</au><au>Zini, Andrea</au><au>DeLodovici, Maria Luisa</au><au>Paciaroni, Maurizio</au><au>Del Sette, Massimo</au><au>Azzini, Cristiano</au><au>Toriello, Antonella</au><au>Musolino, Rossella</au><au>Calabrò, Rocco Salvatore</au><au>Bovi, Paolo</au><au>Sessa, Maria</au><au>Adami, Alessandro</au><au>Silvestrelli, Giorgio</au><au>Cavallini, Anna</au><au>Marcheselli, Simona</au><au>Bonifati, Domenico Marco</au><au>Checcarelli, Nicoletta</au><au>Tancredi, Lucia</au><au>Chiti, Alberto</au><au>Lotti, Enrico Maria</au><au>Del Zotto, Elisabetta</au><au>Tomelleri, Giampaolo</au><au>Spalloni, Alessandra</au><au>Giorli, Elisa</au><au>Costa, Paolo</au><au>Poli, Loris</au><au>Morotti, Andrea</au><au>Caria, Filomena</au><au>Lanari, Alessia</au><au>Giacalone, Giacomo</au><au>Ferrazzi, Paola</au><au>Giossi, Alessia</au><au>Piras, Valeria</au><au>Massucco, Davide</au><au>D’Amore, Cataldo</au><au>Di Lisi, Filomena</au><au>Casetta, Ilaria</au><au>Cucurachi, Laura</au><au>Cotroneo, Masina</au><au>De Vito, Alessandro</au><au>Coloberti, Elisa</au><au>Rasura, Maurizia</au><au>Simone, Anna Maria</au><au>Gamba, Massimo</au><au>Cerrato, Paolo</au><au>Micieli, Giuseppe</au><au>Malferrari, Giovanni</au><au>Melis, Maurizio</au><au>Iacoviello, Licia</au><au>Padovani, Alessandro</au><au>Pezzini, Alessandro</au><aucorp>Italian Project on Stroke in Young Adults Investigators</aucorp><aucorp>for the Italian Project on Stroke in Young Adults Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Migraine and Cervical Artery Dissection: The Italian Project on Stroke in Young Adults</atitle><jtitle>JAMA neurology</jtitle><addtitle>JAMA Neurol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>74</volume><issue>5</issue><spage>512</spage><epage>518</epage><pages>512-518</pages><issn>2168-6149</issn><eissn>2168-6157</eissn><abstract>IMPORTANCE: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). OBJECTIVE: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of consecutive patients aged 18 to 45 years with first-ever acute ischemic stroke enrolled in the multicenter Italian Project on Stroke in Young Adults was conducted between January 1, 2000, and June 30, 2015. In a case-control design, the study assessed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs between patients whose IS was due to CEAD (CEAD IS) and those whose IS was due to a cause other than CEAD (non-CEAD IS) and compared the characteristics of patients with CEAD IS with and without migraine. MAIN OUTCOMES AND MEASURES: Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS. RESULTS: Of the 2485 patients (mean [SD] age, 36.8 [7.1] years; women, 1163 [46.8%]) included in the registry, 334 (13.4%) had CEAD IS and 2151 (86.6%) had non-CEAD IS. Migraine was more common in the CEAD IS group (103 [30.8%] vs 525 [24.4%], P = .01), and the difference was mainly due to migraine without aura (80 [24.0%] vs 335 [15.6%], P < .001). Compared with migraine with aura, migraine without aura was independently associated with CEAD IS (OR, 1.74; 95% CI, 1.30-2.33). The strength of this association was higher in men (OR, 1.99; 95% CI, 1.31-3.04) and in patients 39.0 years or younger (OR, 1.82; 95% CI, 1.22-2.71). The risk factor profile was similar in migrainous and non-migrainous patients with CEAD IS (eg, hypertension, 20 [19.4%] vs 57 [24.7%], P = .29; diabetes, 1 [1.0%] vs 3 [1.3%], P > .99). CONCLUSIONS AND RELEVANCE: In patients with IS aged 18 to 45 years, migraine, especially migraine without aura, is consistently associated with CEAD. This finding suggests common features and warrants further analyses to elucidate the underlying biologic mechanisms.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>28264095</pmid><doi>10.1001/jamaneurol.2016.5704</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-6149 |
| ispartof | JAMA neurology, 2017-05, Vol.74 (5), p.512-518 |
| issn | 2168-6149 2168-6157 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5822194 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adolescent Adult Age Factors Brain Ischemia - epidemiology Case-Control Studies Female Humans Intracranial Arterial Diseases - epidemiology Italy - epidemiology Male Middle Aged Migraine with Aura - epidemiology Migraine without Aura - epidemiology Online First Original Investigation Prospective Studies Registries Sex Factors Stroke - epidemiology Young Adult |
| title | Association Between Migraine and Cervical Artery Dissection: The Italian Project on Stroke in Young Adults |
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