Clinical applications of chemical exchange saturation transfer (CEST) MRI
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2018-01, Vol.47 (1), p.11-27 |
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| description | Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development. Endogenous biomolecules with amide, amine, and hydroxyl groups have been detected during clinical CEST MRI studies, and exogenous CEST agents have also been administered to patients. These CEST MRI tools show promise for contributing to assessments of cerebral ischemia, neurological disorders, lymphedema, osteoarthritis, muscle physiology, and solid tumors. This review summarizes the salient features of clinical CEST MRI protocols and critically evaluates the utility of CEST MRI for these clinical imaging applications.
Level of Evidence: 5
Technical Efficacy: Stage 1
J. Magn. Reson. Imaging 2018;47:11–27. |
| doi_str_mv | 10.1002/jmri.25838 |
| format | Article |
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Level of Evidence: 5
Technical Efficacy: Stage 1
J. Magn. Reson. Imaging 2018;47:11–27.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.25838</identifier><identifier>PMID: 28792646</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Animals ; Biocompatibility ; Biomedical materials ; Biomolecules ; Brain - diagnostic imaging ; Brain Neoplasms - diagnostic imaging ; CEST ; clinical imaging applications ; Contrast Media - chemistry ; Disease Models, Animal ; Female ; Humans ; Hydrogen-Ion Concentration ; Hydroxyl groups ; Image Interpretation, Computer-Assisted ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Inhomogeneity ; Ischemia ; Lymphedema ; Lymphedema - diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Molecular Imaging ; MRI ; Muscle, Skeletal - diagnostic imaging ; Muscles ; Nervous System Diseases - diagnostic imaging ; Neurological diseases ; NMR ; Nuclear magnetic resonance ; Osteoarthritis ; Osteoarthritis - diagnostic imaging ; Phantoms, Imaging ; Radio frequency ; Radio Waves ; Research facilities ; Routines ; Saturation ; Solid tumors ; Stroke - diagnostic imaging ; Therapeutic applications ; Tumors</subject><ispartof>Journal of magnetic resonance imaging, 2018-01, Vol.47 (1), p.11-27</ispartof><rights>2017 International Society for Magnetic Resonance in Medicine</rights><rights>2017 International Society for Magnetic Resonance in Medicine.</rights><rights>2018 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5148-791975becee3afce0d665cd0b1257a432985d50a0c2bc3ba9236ea207a7d62e93</citedby><cites>FETCH-LOGICAL-c5148-791975becee3afce0d665cd0b1257a432985d50a0c2bc3ba9236ea207a7d62e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.25838$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.25838$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28792646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Kyle M.</creatorcontrib><creatorcontrib>Pollard, Alyssa C.</creatorcontrib><creatorcontrib>Pagel, Mark D.</creatorcontrib><title>Clinical applications of chemical exchange saturation transfer (CEST) MRI</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development. Endogenous biomolecules with amide, amine, and hydroxyl groups have been detected during clinical CEST MRI studies, and exogenous CEST agents have also been administered to patients. These CEST MRI tools show promise for contributing to assessments of cerebral ischemia, neurological disorders, lymphedema, osteoarthritis, muscle physiology, and solid tumors. This review summarizes the salient features of clinical CEST MRI protocols and critically evaluates the utility of CEST MRI for these clinical imaging applications.
Level of Evidence: 5
Technical Efficacy: Stage 1
J. Magn. Reson. Imaging 2018;47:11–27.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Biomolecules</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>CEST</subject><subject>clinical imaging applications</subject><subject>Contrast Media - chemistry</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydroxyl groups</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Inhomogeneity</subject><subject>Ischemia</subject><subject>Lymphedema</subject><subject>Lymphedema - diagnostic imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Imaging</subject><subject>MRI</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscles</subject><subject>Nervous System Diseases - diagnostic imaging</subject><subject>Neurological diseases</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Phantoms, Imaging</subject><subject>Radio frequency</subject><subject>Radio Waves</subject><subject>Research facilities</subject><subject>Routines</subject><subject>Saturation</subject><subject>Solid tumors</subject><subject>Stroke - diagnostic imaging</subject><subject>Therapeutic applications</subject><subject>Tumors</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVtLAzEQhYMoVqsv_gBZ8EWF1Vw2m82LIMVLRRG8PIdsdrZN2UtNumr_vWmroj74NDPMx-HMHIT2CD4hGNPTSe3sCeUZy9bQFuGUxmFI10OPOYtJhkUPbXs_wRhLmfBN1KOZkDRN0i00HFS2sUZXkZ5Oq9DMbNv4qC0jM4Z6uYB3M9bNCCKvZ51bAtHM6caX4KLDwcXj01F09zDcQRulrjzsftY-er68eBpcx7f3V8PB-W1sOEmyWEgiBc_BADBdGsBFmnJT4JxQLnTCqMx4wbHGhuaG5VpSloKmWGhRpBQk66Ozle60y2soDDTBTKWmztbazVWrrfq9aexYjdpXxTNKqGBB4PBTwLUvHfiZqq03UFW6gbbzikgquEyETAJ68AedtJ1rwnlqcUWSMUx4oI5XlHGt9w7KbzMEq0VCapGQWiYU4P2f9r_Rr0gCQFbAm61g_o-UuglfX4l-AGL_m6k</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Jones, Kyle M.</creator><creator>Pollard, Alyssa C.</creator><creator>Pagel, Mark D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201801</creationdate><title>Clinical applications of chemical exchange saturation transfer (CEST) MRI</title><author>Jones, Kyle M. ; Pollard, Alyssa C. ; Pagel, Mark D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5148-791975becee3afce0d665cd0b1257a432985d50a0c2bc3ba9236ea207a7d62e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Biomolecules</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>CEST</topic><topic>clinical imaging applications</topic><topic>Contrast Media - chemistry</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydroxyl groups</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Inhomogeneity</topic><topic>Ischemia</topic><topic>Lymphedema</topic><topic>Lymphedema - diagnostic imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Imaging</topic><topic>MRI</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscles</topic><topic>Nervous System Diseases - diagnostic imaging</topic><topic>Neurological diseases</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Phantoms, Imaging</topic><topic>Radio frequency</topic><topic>Radio Waves</topic><topic>Research facilities</topic><topic>Routines</topic><topic>Saturation</topic><topic>Solid tumors</topic><topic>Stroke - diagnostic imaging</topic><topic>Therapeutic applications</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Kyle M.</creatorcontrib><creatorcontrib>Pollard, Alyssa C.</creatorcontrib><creatorcontrib>Pagel, Mark D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Kyle M.</au><au>Pollard, Alyssa C.</au><au>Pagel, Mark D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical applications of chemical exchange saturation transfer (CEST) MRI</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2018-01</date><risdate>2018</risdate><volume>47</volume><issue>1</issue><spage>11</spage><epage>27</epage><pages>11-27</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development. Endogenous biomolecules with amide, amine, and hydroxyl groups have been detected during clinical CEST MRI studies, and exogenous CEST agents have also been administered to patients. These CEST MRI tools show promise for contributing to assessments of cerebral ischemia, neurological disorders, lymphedema, osteoarthritis, muscle physiology, and solid tumors. This review summarizes the salient features of clinical CEST MRI protocols and critically evaluates the utility of CEST MRI for these clinical imaging applications.
Level of Evidence: 5
Technical Efficacy: Stage 1
J. Magn. Reson. Imaging 2018;47:11–27.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28792646</pmid><doi>10.1002/jmri.25838</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Animals Biocompatibility Biomedical materials Biomolecules Brain - diagnostic imaging Brain Neoplasms - diagnostic imaging CEST clinical imaging applications Contrast Media - chemistry Disease Models, Animal Female Humans Hydrogen-Ion Concentration Hydroxyl groups Image Interpretation, Computer-Assisted Image Processing, Computer-Assisted Imaging, Three-Dimensional Inhomogeneity Ischemia Lymphedema Lymphedema - diagnostic imaging Magnetic Resonance Imaging Male Middle Aged Molecular Imaging MRI Muscle, Skeletal - diagnostic imaging Muscles Nervous System Diseases - diagnostic imaging Neurological diseases NMR Nuclear magnetic resonance Osteoarthritis Osteoarthritis - diagnostic imaging Phantoms, Imaging Radio frequency Radio Waves Research facilities Routines Saturation Solid tumors Stroke - diagnostic imaging Therapeutic applications Tumors |
| title | Clinical applications of chemical exchange saturation transfer (CEST) MRI |
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