PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

Loss of the PD-1 receptor promotes the development of T cell non-Hodgkin lymphomas by modulating oncogenic signalling pathways, and blocking these pathways reduces tumourigenesis. Checkpoint factor suppresses lymphoma PD-1 functions as an inhibitory receptor in the immune system and is a target of c...

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Veröffentlicht in:	Nature (London) 2017-12, Vol.552 (7683), p.121-125
Hauptverfasser:	Wartewig, Tim, Kurgyis, Zsuzsanna, Keppler, Selina, Pechloff, Konstanze, Hameister, Erik, Öllinger, Rupert, Maresch, Roman, Buch, Thorsten, Steiger, Katja, Winter, Christof, Rad, Roland, Ruland, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/31 13/95 38 38/91 42 42/44 631/250 631/67 64 64/60 82 96 96/1 96/31 AKT protein Animals Antigen receptors, T cell Apoptosis Carcinogenesis - genetics Cell activation Cell proliferation Cell survival Cells, Cultured Clonal deletion Female Genes, Tumor Suppressor Genomes Haploinsufficiency - genetics Health aspects Humanities and Social Sciences Humans Kinases letter Lymphocytes Lymphocytes T Lymphoma Lymphoma, T-Cell - genetics Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Male Mice multidisciplinary Mutation Non-Hodgkin's lymphomas PD-1 protein Physiological aspects Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Protein kinase C PTEN protein Receptors Rodents Science Signal transduction Signal Transduction - genetics Signaling Stem cells Suppressors T cell receptors T cells T-cell lymphoma T-Lymphocytes - metabolism T-Lymphocytes - pathology Transposon mutagenesis Tumors
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