Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing

Here we highlight the Grc3/Las1 complex, an essential RNA processing machine that is well conserved across eukaryotes and required for processing the pre-ribosomal RNA (pre-rRNA). Las1 is an endoribonuclease that cleaves the pre-rRNA while Grc3 is a polynucleotide kinase that phosphorylates the Las1...

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Veröffentlicht in:	Current genetics 2018-02, Vol.64 (1), p.183-190
Hauptverfasser:	Pillon, Monica C., Stanley, Robin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Assemblies Biochemistry Biomedical and Life Sciences Cell Biology DNA, Intergenic Endoribonucleases - chemistry Endoribonucleases - genetics Endoribonucleases - metabolism Eukaryotes Gene Expression Regulation Humans Kinases Life Sciences Microbial Genetics and Genomics Microbiology Multigene Family Nuclease Plant Sciences Polynucleotide 5'-Hydroxyl-Kinase - chemistry Polynucleotide 5'-Hydroxyl-Kinase - genetics Polynucleotide 5'-Hydroxyl-Kinase - metabolism Polynucleotide kinase Protein Binding Protein Interaction Domains and Motifs Proteomics Review Ribonuclease L Ribonucleic acid RNA RNA processing RNA Processing, Post-Transcriptional rRNA Substrate Specificity
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