Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia
Purpose of Review The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults. Recent Findings AML is a rare aggressive hematologic disease that occur...
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| Veröffentlicht in: | Current geriatrics reports 2017-12, Vol.6 (4), p.247-254 |
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| creator | Storey, Susan Gray, Tamryn Fowler Bryant, Ashley Leak |
| description | Purpose of Review
The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults.
Recent Findings
AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL.
Summary
As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL. |
| doi_str_mv | 10.1007/s13670-017-0227-8 |
| format | Article |
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The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults.
Recent Findings
AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL.
Summary
As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL.</description><identifier>ISSN: 2196-7865</identifier><identifier>EISSN: 2196-7865</identifier><identifier>DOI: 10.1007/s13670-017-0227-8</identifier><identifier>PMID: 29479516</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age ; Aging ; Blood diseases ; Bone marrow ; Cancer therapies ; Chemotherapy ; Comorbidity ; Cytokines ; Diabetes ; Geriatrics/Gerontology ; Hematology and Oncology (GR Williams ; Hospitals ; Hyperglycemia ; Immune system ; Length of stay ; Leukemia ; Medical prognosis ; Medicine ; Medicine & Public Health ; Mortality ; Neurology ; Older people ; Pain Medicine ; Psychopharmacology ; Quality of life ; Remission (Medicine) ; Rheumatology ; Section Editor ; Stem cell transplantation ; Topical Collection on Hematology and Oncology ; Toxicity</subject><ispartof>Current geriatrics reports, 2017-12, Vol.6 (4), p.247-254</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Springer Science+Business Media, LLC 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-bc8a0840807fb713d31ab6ce57ff85c795f5c3fa5717fd2be14763f3044ad00c3</citedby><cites>FETCH-LOGICAL-c470t-bc8a0840807fb713d31ab6ce57ff85c795f5c3fa5717fd2be14763f3044ad00c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13670-017-0227-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2920184551?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,21388,21389,27924,27925,33530,33531,33744,33745,41488,42557,43659,43805,51319,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29479516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Storey, Susan</creatorcontrib><creatorcontrib>Gray, Tamryn Fowler</creatorcontrib><creatorcontrib>Bryant, Ashley Leak</creatorcontrib><title>Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia</title><title>Current geriatrics reports</title><addtitle>Curr Geri Rep</addtitle><addtitle>Curr Geriatr Rep</addtitle><description>Purpose of Review
The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults.
Recent Findings
AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL.
Summary
As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL.</description><subject>Age</subject><subject>Aging</subject><subject>Blood diseases</subject><subject>Bone marrow</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Comorbidity</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Geriatrics/Gerontology</subject><subject>Hematology and Oncology (GR Williams</subject><subject>Hospitals</subject><subject>Hyperglycemia</subject><subject>Immune system</subject><subject>Length of stay</subject><subject>Leukemia</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Neurology</subject><subject>Older people</subject><subject>Pain Medicine</subject><subject>Psychopharmacology</subject><subject>Quality of life</subject><subject>Remission (Medicine)</subject><subject>Rheumatology</subject><subject>Section Editor</subject><subject>Stem cell transplantation</subject><subject>Topical Collection on Hematology and Oncology</subject><subject>Toxicity</subject><issn>2196-7865</issn><issn>2196-7865</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV9rFTEQxRdRbKn9AL5IwBcfujpJNpvsi3C5WFu40gr6HLL505uaTWqyW7nf3pRbaxX6NAPnN2dmOE3zGsN7DMA_FEx7Di1g3gIhvBXPmkOCh77lomfPH_UHzXEp1wCACeuBDS-bAzJ0fGC4P2zkOk0pj974eXeCLre74rUK6HSJevYpniAVDfq6qFB1lBzaeGeRj-giGJvRyixhLuiXn7dopZfZoi87G5I3aGOXH3by6lXzwqlQ7PF9PWq-n376tj5rNxefz9erTas7DnM7aqFAdCCAu5FjaihWY68t484JpuuxjmnqFOOYO0NGizveU0eh65QB0PSo-bj3vVnGyRpt45xVkDfZTyrvZFJe_qtEv5VX6VYyQYBzqAbv7g1y-rnYMsvJF21DUNGmpUgCIGhPe0Eq-vY_9DotOdb3JBkIYNExhiuF95TOqZRs3cMxGORdgnKfoKwJyrsEpagzbx5_8TDxJ68KkD1QqhSvbP67-mnX37ErpjY</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Storey, Susan</creator><creator>Gray, Tamryn Fowler</creator><creator>Bryant, Ashley Leak</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171201</creationdate><title>Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia</title><author>Storey, Susan ; Gray, Tamryn Fowler ; Bryant, Ashley Leak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-bc8a0840807fb713d31ab6ce57ff85c795f5c3fa5717fd2be14763f3044ad00c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aging</topic><topic>Blood diseases</topic><topic>Bone marrow</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Comorbidity</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Geriatrics/Gerontology</topic><topic>Hematology and Oncology (GR Williams</topic><topic>Hospitals</topic><topic>Hyperglycemia</topic><topic>Immune system</topic><topic>Length of stay</topic><topic>Leukemia</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Neurology</topic><topic>Older people</topic><topic>Pain Medicine</topic><topic>Psychopharmacology</topic><topic>Quality of life</topic><topic>Remission (Medicine)</topic><topic>Rheumatology</topic><topic>Section Editor</topic><topic>Stem cell transplantation</topic><topic>Topical Collection on Hematology and Oncology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Storey, Susan</creatorcontrib><creatorcontrib>Gray, Tamryn Fowler</creatorcontrib><creatorcontrib>Bryant, Ashley Leak</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current geriatrics reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Storey, Susan</au><au>Gray, Tamryn Fowler</au><au>Bryant, Ashley Leak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia</atitle><jtitle>Current geriatrics reports</jtitle><stitle>Curr Geri Rep</stitle><addtitle>Curr Geriatr Rep</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>6</volume><issue>4</issue><spage>247</spage><epage>254</epage><pages>247-254</pages><issn>2196-7865</issn><eissn>2196-7865</eissn><abstract>Purpose of Review
The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults.
Recent Findings
AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL.
Summary
As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29479516</pmid><doi>10.1007/s13670-017-0227-8</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Aging Blood diseases Bone marrow Cancer therapies Chemotherapy Comorbidity Cytokines Diabetes Geriatrics/Gerontology Hematology and Oncology (GR Williams Hospitals Hyperglycemia Immune system Length of stay Leukemia Medical prognosis Medicine Medicine & Public Health Mortality Neurology Older people Pain Medicine Psychopharmacology Quality of life Remission (Medicine) Rheumatology Section Editor Stem cell transplantation Topical Collection on Hematology and Oncology Toxicity |
| title | Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia |
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