Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson’s Disease
Objectives: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson’s disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigat...
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| Veröffentlicht in: | Journal of the International Neuropsychological Society 2018-03, Vol.24 (3), p.269-282 |
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| creator | Szymkowicz, Sarah M. Dotson, Vonetta M. Jones, Jacob D. Okun, Michael S. Bowers, Dawn |
| description | Objectives: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson’s disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. Methods: A sample of 138 non-demented individuals with PD (mean age=64.51±7.43 years) underwent neuropsychological testing and completed the Beck Depression Inventory, 2nd Edition, and Apathy Scale. Separate hierarchical regression models examined the relationship between symptom dimensions of depression and apathy (“pure” depressive symptoms, “pure” apathy, loss of interest/pleasure [anhedonia], and somatic symptoms) and three cognitive domain composites: immediate verbal memory, delayed verbal memory, and executive function. Results: After adjusting for general cognitive status and the influence of the other symptom dimensions, “pure” depressive symptoms were negatively associated with the delayed verbal memory composite (p |
| doi_str_mv | 10.1017/S1355617717001011 |
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However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. Methods: A sample of 138 non-demented individuals with PD (mean age=64.51±7.43 years) underwent neuropsychological testing and completed the Beck Depression Inventory, 2nd Edition, and Apathy Scale. Separate hierarchical regression models examined the relationship between symptom dimensions of depression and apathy (“pure” depressive symptoms, “pure” apathy, loss of interest/pleasure [anhedonia], and somatic symptoms) and three cognitive domain composites: immediate verbal memory, delayed verbal memory, and executive function. Results: After adjusting for general cognitive status and the influence of the other symptom dimensions, “pure” depressive symptoms were negatively associated with the delayed verbal memory composite (p<.034) and somatic symptoms were positively associated with the executive function composite (p<.026). No symptom dimensions were significantly related to the immediate verbal memory composite. Conclusions: Findings suggest that specific mood symptoms are associated with delayed verbal memory and executive function performance in non-demented patients with PD. Further research is needed to better understand possible mechanisms through which specific symptom dimensions of depression and apathy are associated with cognition in PD. (JINS, 2018, 24, 269–282)</description><identifier>ISSN: 1355-6177</identifier><identifier>EISSN: 1469-7661</identifier><identifier>DOI: 10.1017/S1355617717001011</identifier><identifier>PMID: 29032789</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Aged ; Aged, 80 and over ; Apathy ; Brain research ; Cognition ; Cognition & reasoning ; Cognitive ability ; Depression - epidemiology ; Depression - etiology ; Depression - psychology ; Emotional behavior ; Executive Function ; Female ; Hedonic response ; Humans ; Male ; Measuring techniques ; Medical imaging ; Medicine ; Memory ; Mental depression ; Middle Aged ; Mood ; Motivation ; Movement disorders ; Neurodegenerative diseases ; Neuropsychological Tests ; Parkinson Disease - complications ; Parkinson Disease - psychology ; Parkinson's disease ; Psychiatric Status Rating Scales ; Psychology ; Regression analysis ; Social research</subject><ispartof>Journal of the International Neuropsychological Society, 2018-03, Vol.24 (3), p.269-282</ispartof><rights>Copyright © The International Neuropsychological Society 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-9ea4f4eb5ed4908df5bb6e037a9533a172d14d7e41e64fab8979a5629a889e283</citedby><cites>FETCH-LOGICAL-c471t-9ea4f4eb5ed4908df5bb6e037a9533a172d14d7e41e64fab8979a5629a889e283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1355617717001011/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,776,780,881,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29032789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szymkowicz, Sarah M.</creatorcontrib><creatorcontrib>Dotson, Vonetta M.</creatorcontrib><creatorcontrib>Jones, Jacob D.</creatorcontrib><creatorcontrib>Okun, Michael S.</creatorcontrib><creatorcontrib>Bowers, Dawn</creatorcontrib><title>Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson’s Disease</title><title>Journal of the International Neuropsychological Society</title><addtitle>J Int Neuropsychol Soc</addtitle><description>Objectives: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson’s disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. Methods: A sample of 138 non-demented individuals with PD (mean age=64.51±7.43 years) underwent neuropsychological testing and completed the Beck Depression Inventory, 2nd Edition, and Apathy Scale. Separate hierarchical regression models examined the relationship between symptom dimensions of depression and apathy (“pure” depressive symptoms, “pure” apathy, loss of interest/pleasure [anhedonia], and somatic symptoms) and three cognitive domain composites: immediate verbal memory, delayed verbal memory, and executive function. Results: After adjusting for general cognitive status and the influence of the other symptom dimensions, “pure” depressive symptoms were negatively associated with the delayed verbal memory composite (p<.034) and somatic symptoms were positively associated with the executive function composite (p<.026). No symptom dimensions were significantly related to the immediate verbal memory composite. Conclusions: Findings suggest that specific mood symptoms are associated with delayed verbal memory and executive function performance in non-demented patients with PD. Further research is needed to better understand possible mechanisms through which specific symptom dimensions of depression and apathy are associated with cognition in PD. (JINS, 2018, 24, 269–282)</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apathy</subject><subject>Brain research</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Depression - psychology</subject><subject>Emotional behavior</subject><subject>Executive Function</subject><subject>Female</subject><subject>Hedonic response</subject><subject>Humans</subject><subject>Male</subject><subject>Measuring techniques</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Memory</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mood</subject><subject>Motivation</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neuropsychological Tests</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson's disease</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology</subject><subject>Regression analysis</subject><subject>Social research</subject><issn>1355-6177</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1u1DAUhS0EoqXwAGyQJTZsAr6xHccbpGrKn1QJRItYWs7kZuIhsVM7gzQ7XoPX40lw6FD-xMrX93z32FeHkIfAngID9ewCuJQVKAWKsdyBW-QYRKULVVVwO9dZLhb9iNxLaZsZDozdJUelZrxUtT4m24v9OM1hpGduRJ9c8ImGjp7hFDEtV2p9S08nO_f7H-Vljy7S9zjYeYF7N9GPbu7pKmy8W1rUefrOxk_Op-C_ffmasnVCm_A-udPZIeGDw3lCPrx8cbl6XZy_ffVmdXperIWCudBoRSewkdgKzeq2k01TIePKasm5BVW2IFqFArASnW1qrbSVValtXWssa35Cnl_7TrtmxHaNfo52MFN0o417E6wzfyre9WYTPhtZl6yExeDJwSCGqx2m2YwurXEYrMewSwa0BFmpki_o47_QbdhFn9czJWNCcC5AZgquqXUMKUXsbj4DzCxJmn-SzDOPft_iZuJndBngB1M7NtG1G_z19v9tvwP8Y6pH</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Szymkowicz, Sarah M.</creator><creator>Dotson, Vonetta M.</creator><creator>Jones, Jacob D.</creator><creator>Okun, Michael S.</creator><creator>Bowers, Dawn</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180301</creationdate><title>Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson’s Disease</title><author>Szymkowicz, Sarah M. ; Dotson, Vonetta M. ; Jones, Jacob D. ; Okun, Michael S. ; Bowers, Dawn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-9ea4f4eb5ed4908df5bb6e037a9533a172d14d7e41e64fab8979a5629a889e283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apathy</topic><topic>Brain research</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Depression - epidemiology</topic><topic>Depression - etiology</topic><topic>Depression - psychology</topic><topic>Emotional behavior</topic><topic>Executive Function</topic><topic>Female</topic><topic>Hedonic response</topic><topic>Humans</topic><topic>Male</topic><topic>Measuring techniques</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Memory</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Mood</topic><topic>Motivation</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neuropsychological Tests</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson's disease</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology</topic><topic>Regression analysis</topic><topic>Social research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szymkowicz, Sarah M.</creatorcontrib><creatorcontrib>Dotson, Vonetta M.</creatorcontrib><creatorcontrib>Jones, Jacob D.</creatorcontrib><creatorcontrib>Okun, Michael S.</creatorcontrib><creatorcontrib>Bowers, Dawn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the International Neuropsychological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szymkowicz, Sarah M.</au><au>Dotson, Vonetta M.</au><au>Jones, Jacob D.</au><au>Okun, Michael S.</au><au>Bowers, Dawn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson’s Disease</atitle><jtitle>Journal of the International Neuropsychological Society</jtitle><addtitle>J Int Neuropsychol Soc</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>24</volume><issue>3</issue><spage>269</spage><epage>282</epage><pages>269-282</pages><issn>1355-6177</issn><eissn>1469-7661</eissn><abstract>Objectives: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson’s disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. Methods: A sample of 138 non-demented individuals with PD (mean age=64.51±7.43 years) underwent neuropsychological testing and completed the Beck Depression Inventory, 2nd Edition, and Apathy Scale. Separate hierarchical regression models examined the relationship between symptom dimensions of depression and apathy (“pure” depressive symptoms, “pure” apathy, loss of interest/pleasure [anhedonia], and somatic symptoms) and three cognitive domain composites: immediate verbal memory, delayed verbal memory, and executive function. Results: After adjusting for general cognitive status and the influence of the other symptom dimensions, “pure” depressive symptoms were negatively associated with the delayed verbal memory composite (p<.034) and somatic symptoms were positively associated with the executive function composite (p<.026). No symptom dimensions were significantly related to the immediate verbal memory composite. Conclusions: Findings suggest that specific mood symptoms are associated with delayed verbal memory and executive function performance in non-demented patients with PD. Further research is needed to better understand possible mechanisms through which specific symptom dimensions of depression and apathy are associated with cognition in PD. (JINS, 2018, 24, 269–282)</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>29032789</pmid><doi>10.1017/S1355617717001011</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Apathy Brain research Cognition Cognition & reasoning Cognitive ability Depression - epidemiology Depression - etiology Depression - psychology Emotional behavior Executive Function Female Hedonic response Humans Male Measuring techniques Medical imaging Medicine Memory Mental depression Middle Aged Mood Motivation Movement disorders Neurodegenerative diseases Neuropsychological Tests Parkinson Disease - complications Parkinson Disease - psychology Parkinson's disease Psychiatric Status Rating Scales Psychology Regression analysis Social research |
| title | Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson’s Disease |
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