Enhancing toxin-based vaccines against botulism

•In a mouse model of botulism, M-BoNT/A1 was not toxic at >106-fold greater amounts than native BoNT/A.•M-BoNT/A1(W1266A) (M-BoNT/A1W) was created to prevent neuronal cell binding.•M-BoNT/A1 vaccination protected against challenge by 106 LD50 of native BoNT/A1.•LCHCN elicited a higher neutralizin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2018-02, Vol.36 (6), p.827-832
Hauptverfasser:	Przedpelski, Amanda, Tepp, William H., Zuverink, Madison, Johnson, Eric A., Pellet, Sabine, Barbieri, Joseph T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies Antibodies, Bacterial - immunology Antibodies, Neutralizing - immunology Antigens, Bacterial - immunology Attachment Bacterial Vaccines - immunology Binding Bioassays Botulinum neurotoxin Botulinum neurotoxin A1 Botulinum neurotoxin A2 Botulinum toxin Botulinum Toxins - immunology Botulism Botulism - immunology Botulism - prevention & control Catalysis Catalytic activity Chains Clostridium botulinum Clostridium botulinum - immunology Disease Models, Animal E coli ELISA Enzyme-Linked Immunosorbent Assay Epitopes - immunology Escherichia coli Experiments Food contamination Glycerol Humans Immune response Immune system Immunization Immunoglobulins Laboratories Medical research Mice Mutation Neurons - immunology Neurons - metabolism Neurotoxins Neutralizing Proteins Recombinant Proteins Toxicity Toxins Translocation Vaccine Vaccines Waterborne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!