Circulating liver-specific microRNAs in cynomolgus monkeys

Circulating microRNAs (miRNAs) can potentially be used as sensitive and specific biomarkers for tissue injury. However, the usefulness of circulating miRNAs as safety biomarkers in nonclinical toxicological studies using nonhuman primates is debatable owing to the limited information on organ-specif...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Toxicologic Pathology 2018, Vol.31(1), pp.3-13
Hauptverfasser:	Iguchi, Takuma, Sakurai, Ken, Tamai, Satoshi, Mori, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Analgesics Biomarkers cynomolgus monkeys drug-induced liver injury Hepatocytes Hepatotoxicity Intestine Kidneys Liver microRNA MicroRNAs miRNA Monkeys Necrosis Next-generation sequencing Polymerase chain reaction Primates Reverse transcription Toxicity testing Variation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!