Increased Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients
Diabetes mellitus (DM) is a metabolic disease characterized by persistent high levels of glucose in plasma. Chronic hyperglycemia is thought to increase oxidative stress and the formation of free radicals that in turn damage cells. Thus, we decided to determine the frequency of nuclear abnormalities...
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| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-8 |
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| creator | Ramos-Payán, Rosalío Sánchez-Schmitz, Guzman Romero Quintana, Jose Geovanni Ayala Ham, Alfredo García Jau, Rosa Alicia Olimón-Andalón, Vicente Aguilar-Medina, Maribel Quintero Ojeda, Jesús Emilo Silva-Benítez, Erika de Lourdes |
| description | Diabetes mellitus (DM) is a metabolic disease characterized by persistent high levels of glucose in plasma. Chronic hyperglycemia is thought to increase oxidative stress and the formation of free radicals that in turn damage cells. Thus, we decided to determine the frequency of nuclear abnormalities in epithelial cells from cheek and tongue mucosa of DM patients with type 1 (DM1, treated only with insulin) and type 2 (DM2, treated with metformin) using the buccal micronucleus cytome (BMCyt) assay. Micronuclei frequency in cheek epithelial cells was higher in both DM1 (0.75 ± 0.31, P |
| doi_str_mv | 10.1155/2018/4898153 |
| format | Article |
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Chronic hyperglycemia is thought to increase oxidative stress and the formation of free radicals that in turn damage cells. Thus, we decided to determine the frequency of nuclear abnormalities in epithelial cells from cheek and tongue mucosa of DM patients with type 1 (DM1, treated only with insulin) and type 2 (DM2, treated with metformin) using the buccal micronucleus cytome (BMCyt) assay. Micronuclei frequency in cheek epithelial cells was higher in both DM1 (0.75 ± 0.31, P<0.001) and DM2 (0.52 ± 0.27, P<0.001) patients, as compared to healthy controls (0.07 ± 0.06). Similarly, micronuclei frequency in tongue epithelium was increased in DM1 (0.81 ± 0.22, P<0.001) and DM2 (0.41 ± 0.21, P<0.001) groups, in comparison to controls (0.06 ± 0.05). Besides, we found a positive correlation between micronuclei frequency and the onset time of DM2 in both cheek (ρ = 0.69, P<0.001) and tongue epithelial cells (ρ = 0.71, P<0.001), but not with onset time of DM1 or age of the patients. Considering all this, we pose that BMCyt could serve as a fast and easily accessible test to assess genotoxic damage during dental visits of DM patients, helping to monitor their disease.]]></description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/4898153</identifier><identifier>PMID: 29546061</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Abnormalities ; Biomedical research ; Cancer ; Care and treatment ; Cheek ; Cytotoxicity ; Damage assessment ; Deoxyribonucleic acid ; Diabetes ; Diabetes mellitus ; DNA ; Endocrinology ; Epithelial cells ; Epithelium ; Free radicals ; Genotoxicity ; Hyperglycemia ; Insulin ; Insulin resistance ; Ionizing radiation ; Lingual epithelium ; Medical research ; Metformin ; Micronuclei ; Mortality ; Mucosa ; Mutagenesis ; Mutation ; Odontology ; Oxidative stress ; Patients ; Tongue ; Toxicology</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-8</ispartof><rights>Copyright © 2018 Jesús Emilo Quintero Ojeda et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Jesús Emilo Quintero Ojeda et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Jesús Emilo Quintero Ojeda et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-3e260759ad5f3f4800b6664cfd64bf7899250f0bc6e53b2172a8aa736e7247fc3</citedby><cites>FETCH-LOGICAL-c499t-3e260759ad5f3f4800b6664cfd64bf7899250f0bc6e53b2172a8aa736e7247fc3</cites><orcidid>0000-0003-2646-106X ; 0000-0001-9995-5680 ; 0000-0001-7500-7571 ; 0000-0002-3566-7505</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818950/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818950/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29546061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kantartzis, Konstantinos</contributor><creatorcontrib>Ramos-Payán, Rosalío</creatorcontrib><creatorcontrib>Sánchez-Schmitz, Guzman</creatorcontrib><creatorcontrib>Romero Quintana, Jose Geovanni</creatorcontrib><creatorcontrib>Ayala Ham, Alfredo</creatorcontrib><creatorcontrib>García Jau, Rosa Alicia</creatorcontrib><creatorcontrib>Olimón-Andalón, Vicente</creatorcontrib><creatorcontrib>Aguilar-Medina, Maribel</creatorcontrib><creatorcontrib>Quintero Ojeda, Jesús Emilo</creatorcontrib><creatorcontrib>Silva-Benítez, Erika de Lourdes</creatorcontrib><title>Increased Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description><![CDATA[Diabetes mellitus (DM) is a metabolic disease characterized by persistent high levels of glucose in plasma. Chronic hyperglycemia is thought to increase oxidative stress and the formation of free radicals that in turn damage cells. Thus, we decided to determine the frequency of nuclear abnormalities in epithelial cells from cheek and tongue mucosa of DM patients with type 1 (DM1, treated only with insulin) and type 2 (DM2, treated with metformin) using the buccal micronucleus cytome (BMCyt) assay. Micronuclei frequency in cheek epithelial cells was higher in both DM1 (0.75 ± 0.31, P<0.001) and DM2 (0.52 ± 0.27, P<0.001) patients, as compared to healthy controls (0.07 ± 0.06). Similarly, micronuclei frequency in tongue epithelium was increased in DM1 (0.81 ± 0.22, P<0.001) and DM2 (0.41 ± 0.21, P<0.001) groups, in comparison to controls (0.06 ± 0.05). Besides, we found a positive correlation between micronuclei frequency and the onset time of DM2 in both cheek (ρ = 0.69, P<0.001) and tongue epithelial cells (ρ = 0.71, P<0.001), but not with onset time of DM1 or age of the patients. Considering all this, we pose that BMCyt could serve as a fast and easily accessible test to assess genotoxic damage during dental visits of DM patients, helping to monitor their disease.]]></description><subject>Abnormalities</subject><subject>Biomedical research</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cheek</subject><subject>Cytotoxicity</subject><subject>Damage assessment</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>DNA</subject><subject>Endocrinology</subject><subject>Epithelial cells</subject><subject>Epithelium</subject><subject>Free radicals</subject><subject>Genotoxicity</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Ionizing radiation</subject><subject>Lingual epithelium</subject><subject>Medical research</subject><subject>Metformin</subject><subject>Micronuclei</subject><subject>Mortality</subject><subject>Mucosa</subject><subject>Mutagenesis</subject><subject>Mutation</subject><subject>Odontology</subject><subject>Oxidative 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Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients</title><author>Ramos-Payán, Rosalío ; Sánchez-Schmitz, Guzman ; Romero Quintana, Jose Geovanni ; Ayala Ham, Alfredo ; García Jau, Rosa Alicia ; Olimón-Andalón, Vicente ; Aguilar-Medina, Maribel ; Quintero Ojeda, Jesús Emilo ; Silva-Benítez, Erika de Lourdes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-3e260759ad5f3f4800b6664cfd64bf7899250f0bc6e53b2172a8aa736e7247fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abnormalities</topic><topic>Biomedical research</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cheek</topic><topic>Cytotoxicity</topic><topic>Damage assessment</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>DNA</topic><topic>Endocrinology</topic><topic>Epithelial cells</topic><topic>Epithelium</topic><topic>Free radicals</topic><topic>Genotoxicity</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Ionizing radiation</topic><topic>Lingual epithelium</topic><topic>Medical research</topic><topic>Metformin</topic><topic>Micronuclei</topic><topic>Mortality</topic><topic>Mucosa</topic><topic>Mutagenesis</topic><topic>Mutation</topic><topic>Odontology</topic><topic>Oxidative stress</topic><topic>Patients</topic><topic>Tongue</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos-Payán, Rosalío</creatorcontrib><creatorcontrib>Sánchez-Schmitz, Guzman</creatorcontrib><creatorcontrib>Romero Quintana, Jose Geovanni</creatorcontrib><creatorcontrib>Ayala Ham, Alfredo</creatorcontrib><creatorcontrib>García Jau, Rosa Alicia</creatorcontrib><creatorcontrib>Olimón-Andalón, Vicente</creatorcontrib><creatorcontrib>Aguilar-Medina, 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Maribel</au><au>Quintero Ojeda, Jesús Emilo</au><au>Silva-Benítez, Erika de Lourdes</au><au>Kantartzis, Konstantinos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract><![CDATA[Diabetes mellitus (DM) is a metabolic disease characterized by persistent high levels of glucose in plasma. Chronic hyperglycemia is thought to increase oxidative stress and the formation of free radicals that in turn damage cells. Thus, we decided to determine the frequency of nuclear abnormalities in epithelial cells from cheek and tongue mucosa of DM patients with type 1 (DM1, treated only with insulin) and type 2 (DM2, treated with metformin) using the buccal micronucleus cytome (BMCyt) assay. Micronuclei frequency in cheek epithelial cells was higher in both DM1 (0.75 ± 0.31, P<0.001) and DM2 (0.52 ± 0.27, P<0.001) patients, as compared to healthy controls (0.07 ± 0.06). Similarly, micronuclei frequency in tongue epithelium was increased in DM1 (0.81 ± 0.22, P<0.001) and DM2 (0.41 ± 0.21, P<0.001) groups, in comparison to controls (0.06 ± 0.05). Besides, we found a positive correlation between micronuclei frequency and the onset time of DM2 in both cheek (ρ = 0.69, P<0.001) and tongue epithelial cells (ρ = 0.71, P<0.001), but not with onset time of DM1 or age of the patients. Considering all this, we pose that BMCyt could serve as a fast and easily accessible test to assess genotoxic damage during dental visits of DM patients, helping to monitor their disease.]]></abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29546061</pmid><doi>10.1155/2018/4898153</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2646-106X</orcidid><orcidid>https://orcid.org/0000-0001-9995-5680</orcidid><orcidid>https://orcid.org/0000-0001-7500-7571</orcidid><orcidid>https://orcid.org/0000-0002-3566-7505</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Biomedical research Cancer Care and treatment Cheek Cytotoxicity Damage assessment Deoxyribonucleic acid Diabetes Diabetes mellitus DNA Endocrinology Epithelial cells Epithelium Free radicals Genotoxicity Hyperglycemia Insulin Insulin resistance Ionizing radiation Lingual epithelium Medical research Metformin Micronuclei Mortality Mucosa Mutagenesis Mutation Odontology Oxidative stress Patients Tongue Toxicology |
| title | Increased Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients |
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