Sustained Release of Immunosuppressant by Nanoparticle-anchoring Hydrogel Scaffold Improved the Survival of Transplanted Stem Cells and Tissue Regeneration

The outcome of scaffold-based stem cell transplantation remains unsatisfied due to the poor survival of transplanted cells. One of the major hurdles associated with the stem cell survival is the immune rejection, which can be effectively reduced by the use of immunosuppressant. However, ideal locali...

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Veröffentlicht in:	Theranostics 2018, Vol.8 (4), p.878-893
Hauptverfasser:	Li, Ruixiang, Liang, Jianming, He, Yuwei, Qin, Jing, He, Huining, Lee, Seungjin, Pang, Zhiqing, Wang, Jianxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival Delayed-Action Preparations - administration & dosage Disease Models, Animal Endothelial Progenitor Cells - physiology Guided Tissue Regeneration - methods Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Immunosuppressive Agents - administration & dosage Ischemia - therapy Mice, Inbred BALB C Nanoparticles - administration & dosage Polylactic Acid-Polyglycolic Acid Copolymer Research Paper Tacrolimus - administration & dosage Treatment Outcome
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