A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease

Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of the CYP4A11 and CYP4F2 genes are associated with the risk of CAD in Russian population....

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Veröffentlicht in:	Disease markers 2018-01, Vol.2018 (2018), p.1-12
Hauptverfasser:	Polonikov, Alexey V., Solodilova, Maria A., Stepanov, Vadim, Vagaytseva, Kseniya, Bocharova, Anna, Bykanova, Marina, Kharchenko, Alexander, Ponomarenko, Irina, Sirotina, Svetlana, Churnosov, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Binding Sites Biosynthesis Cardiovascular disease Case-Control Studies Coronary artery Coronary artery disease Coronary Artery Disease - diagnosis Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Coronary vessels Cytochrome P-450 Cytochrome P-450 CYP4A - genetics Cytochrome P-450 CYP4A - metabolism Cytochrome P450 Family 4 - genetics Cytochrome P450 Family 4 - metabolism Deoxyribonucleic acid Disease susceptibility DNA DNA binding proteins Epistasis Epistasis, Genetic Female Gene Expression Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Haplotypes Heart diseases Humans Male Medical research Medicine, Experimental Middle Aged Pathogenesis Physiological aspects Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic Protein Binding Questions and answers Risk Russia Sex Factors Single-nucleotide polymorphism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Vasoactive agents
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