The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis

Synovial sarcomas are deadly soft tissue malignancies associated with t(X;18) balanced chromosomal translocations. Expression of the apoptotic regulator BCL2 is prominent in synovial sarcomas and has prompted the hypothesis that synovial sarcomagenesis may depend on it. Herein, it is demonstrated th...

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Veröffentlicht in:	Molecular cancer research 2017-12, Vol.15 (12), p.1733-1740
Hauptverfasser:	Barrott, Jared J, Zhu, Ju-Fen, Smith-Fry, Kyllie, Susko, Asia M, Nollner, Dakota, Burrell, Lance D, Pozner, Amir, Capecchi, Mario R, Yap, Jeffrey T, Cannon-Albright, Lisa A, Deng, Xingming, Jones, Kevin B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects bcl-X Protein - genetics Benzimidazoles - administration & dosage Biotechnology Carcinogenesis - genetics Cell Line, Tumor Chromosome translocations Clustering Disease Models, Animal Gene Expression Regulation, Neoplastic - drug effects Genetic engineering Humans Inhibition Mice Mice, Knockout Mitochondria Mitochondria - genetics Mitochondria - pathology Pharmacology Population genetics Proto-Oncogene Proteins c-bcl-2 - genetics Sarcoma Sarcoma, Synovial - drug therapy Sarcoma, Synovial - genetics Sarcoma, Synovial - pathology Signal Transduction - drug effects Signaling Synovial sarcoma Translocation, Genetic - genetics Tumor cell lines Tumorigenesis Tumors
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