Neuronal control of astrocytic respiration through a variant of the Crabtree effect

Aerobic glycolysis is a phenomenon that in the long term contributes to synaptic formation and growth, is reduced by normal aging, and correlates with amyloid beta deposition. Aerobic glycolysis starts within seconds of neural activity and it is not obvious why energetic efficiency should be comprom...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-02, Vol.115 (7), p.1623-1628
Hauptverfasser:	Fernández-Moncada, Ignacio, Ruminot, Iván, Robles-Maldonado, Daniel, Alegría, Karin, Deitmer, Joachim W., Barros, L. Felipe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Aging Animals Astrocytes Astrocytes - cytology Astrocytes - physiology Bicarbonates Biological Sciences Brain Brain slice preparation Carbonates Cell culture Cells Cells, Cultured Coding Data processing Electron transport Energy consumption Energy demand Energy Metabolism Fluorescence resonance energy transfer Genetic code Glycolysis Glycolysis - physiology Hippocampus Hippocampus - cytology Hippocampus - physiology Information processing Male Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Mitochondria Mitochondria - physiology Neurons - cytology Neurons - physiology Oxygen Oxygen Consumption Respiration Sodium-Bicarbonate Symporters - physiology
Online-Zugang:	Volltext
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