Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach

ObjectiveLrig1 is a marker of proliferative and quiescent stem cells in the skin and intestine. We examined whether Lrig1-expressing cells are long-lived gastric progenitors in gastric glands in the mouse stomach. We also investigated how the Lrig1-expressing progenitor cells contribute to the regen...

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Veröffentlicht in:	Gut 2018-09, Vol.67 (9), p.1595-1605
Hauptverfasser:	Choi, Eunyoung, Lantz, Tyler L, Vlacich, Gregory, Keeley, Theresa M, Samuelson, Linda C, Coffey, Robert J, Goldenring, James R, Powell, Anne E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy Biology Biomarkers - metabolism Cancer Cell Lineage Disease Models, Animal Epidermal growth factor Epithelial cells Gastric glands Gastric mucosa Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastroenterology Glands Homeostasis Intestine Labeling Ligands Medical prognosis Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Knockout Mucous membrane Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Parietal cells Predictive Value of Tests Progenitor cells Rodents Sensitivity and Specificity Skin Small intestine Stem cell transplantation Stem cells Stem Cells - metabolism Stomach Stomach Ulcer - chemically induced Stomach Ulcer - genetics Stomach Ulcer - metabolism Wound Healing
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