Adaptive Mutations in RNA Polymerase and the Transcriptional Terminator Rho Have Similar Effects on Escherichia coli Gene Expression

Modifications to transcriptional regulators play a major role in adaptation. Here, we compared the effects of multiple beneficial mutations within and between Escherichia coli rpoB, the gene encoding the RNA polymerase β subunit, and rho, which encodes a transcriptional terminator. These two genes h...

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Veröffentlicht in:	Molecular biology and evolution 2017-11, Vol.34 (11), p.2839-2855
Hauptverfasser:	González-González, Andrea, Hug, Shaun M., Rodríguez-Verdugo, Alejandra, Patel, Jagdish Suresh, Gaut, Brandon S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Discoveries DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Escherichia coli - genetics Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Evolution, Molecular Gene Expression Regulation, Bacterial - genetics Mutation - genetics Phenotype Terminator Regions, Genetic - genetics
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