BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease

SEE ROGAEVA AND SCHMITT-ULMS DOI101093/AWW201 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decline and hi...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2016-10, Vol.139 (Pt 10), p.2766-2777
Hauptverfasser:	Lim, Yen Ying, Hassenstab, Jason, Cruchaga, Carlos, Goate, Alison, Fagan, Anne M, Benzinger, Tammie L S, Maruff, Paul, Snyder, Peter J, Masters, Colin L, Allegri, Ricardo, Chhatwal, Jasmeer, Farlow, Martin R, Graff-Radford, Neill R, Laske, Christoph, Levin, Johannes, McDade, Eric, Ringman, John M, Rossor, Martin, Salloway, Stephen, Schofield, Peter R, Holtzman, David M, Morris, John C, Bateman, Randall J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Brain-Derived Neurotrophic Factor - genetics Female Heterozygote Hippocampus - diagnostic imaging Hippocampus - physiology Humans Male Memory Disorders - diagnostic imaging Memory Disorders - genetics Methionine - genetics Middle Aged Original tau Proteins - genetics Valine - genetics
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