ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair

Abstract Homologous recombination (HR), which mediates the repair of DNA double-strand breaks (DSB), is crucial for maintaining genomic integrity and enhancing survival in response to chemotherapy and radiotherapy in human cancers. However, the mechanisms of HR repair in treatment resistance for the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 2018-02, Vol.46 (3), p.1266-1279
Hauptverfasser:	Chen, Guo, Chen, Jianxiang, Qiao, Yiting, Shi, Yaru, Liu, Wei, Zeng, Qi, Xie, Hui, Shi, Xiaorui, Sun, Youwei, Liu, Xu, Li, Tongyu, Zhou, Liqian, Wan, Jianqin, Xie, Tian, Wang, Hangxiang, Wang, Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism Binding Sites Camptothecin - therapeutic use Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor DNA Breaks, Double-Stranded DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Drug Resistance, Neoplasm - genetics Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Female Genome Integrity, Repair and Genomic Instability Humans Hydroxyurea - therapeutic use Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Mice Mice, Nude Nuclear Proteins - genetics Nuclear Proteins - metabolism Osteoblasts - drug effects Osteoblasts - metabolism Osteoblasts - pathology Phosphorylation Protein Binding Recombinational DNA Repair Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - pathology Survival Analysis Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!