Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine

Oxidative stress plays a fundamental role in abdominal aortic aneurysm (AAA) formation. Activated polymorphonuclear leukocytes (or neutrophils) are associated with AAA and express myeloperoxidase (MPO), which promotes inflammation, matrix degradation, and other pathological features of AAA, includin...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2017-12, Vol.313 (6), p.H1168-H1179
Hauptverfasser:	Kim, Ha Won, Blomkalns, Andra L, Ogbi, Mourad, Thomas, Manesh, Gavrila, Daniel, Neltner, Bonnie S, Cassis, Lisa A, Thompson, Robert W, Weiss, Robert M, Lindower, Paul D, Blanco, Victor M, McCormick, Michael L, Daugherty, Alan, Fu, Xiaoming, Hazen, Stanley L, Stansfield, Brian K, Huo, Yuqing, Fulton, David J, Chatterjee, Tapan, Weintraub, Neal L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amyloid Aneurysms Angiotensin II Animal models Animals Antioxidants - pharmacology Aorta, Abdominal - drug effects Aorta, Abdominal - enzymology Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - chemically induced Aortic Aneurysm, Abdominal - enzymology Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - prevention & control Aortic aneurysms Apolipoprotein E Calcium Chloride Cell activation Data processing Dietary supplements Disease Models, Animal Drinking water Elastase Elastin Gene Deletion Hypochlorous acid Leukocytes Leukocytes (neutrophilic) Leukocytes (polymorphonuclear) Macrophages Male Matrix metalloproteinase Metalloproteinase Mice Mice, Inbred C57BL Mice, Knockout, ApoE Neutrophils - drug effects Neutrophils - enzymology Oral administration Oxidants Oxidative stress Oxidative Stress - drug effects Oxidizing agents Pancreatic Elastase Pathogenesis Patients Peroxidase Peroxidase - deficiency Peroxidase - genetics Peroxidase - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Serum Amyloid A Protein - metabolism Taurine - pharmacology
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