c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

The transcription factor c-MAF is required for the generation of Helicobacter -specific regulatory T cells that selectively restrain pro-inflammatory T H 17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease. Tolerance mechanism against...

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Veröffentlicht in:	Nature (London) 2018-02, Vol.554 (7692), p.373-377
Hauptverfasser:	Xu, Mo, Pokrovskii, Maria, Ding, Yi, Yi, Ren, Au, Christy, Harrison, Oliver J., Galan, Carolina, Belkaid, Yasmine, Bonneau, Richard, Littman, Dan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/21 13/31 13/44 38/23 38/39 38/90 38/91 631/250/2152/1566/2493 631/250/2152/569/2495 631/250/347 631/250/38 631/326/2565/2134 64/60 82 96 96/35 Accumulation Animals Autoimmune diseases Bacteria Bioengineering c-Maf protein Colitis Colitis - immunology Colitis - microbiology Colitis - pathology Colonization Deactivation Differentiation Female Forkhead Transcription Factors - metabolism Foxp3 protein Genetic factors Helicobacter hepaticus - genetics Helicobacter hepaticus - immunology Helicobacter hepaticus - pathogenicity Helicobacter infections Helper cells Homeostasis Host-bacteria relationships Host-Pathogen Interactions Humanities and Social Sciences Immune Tolerance Immunologic tolerance Immunological tolerance Immunology Immunoregulation Inactivation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 10 Interleukin-10 - biosynthesis Interleukin-10 - deficiency Interleukin-10 - immunology Intestines - immunology Intestines - microbiology Large intestine letter Lymphocytes Lymphocytes T Male Mice Microbiota Microorganisms multidisciplinary Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Pathogenesis Physiological research Proto-Oncogene Proteins c-maf - deficiency Proto-Oncogene Proteins c-maf - metabolism Rodents Science Small intestine T cell receptors T cells T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th17 Cells - cytology Th17 Cells - immunology
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