Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists

Dopamine receptors play an integral role in controlling brain physiology. Importantly, subtype selective agonists and antagonists of dopamine receptors with biased signaling properties have been successful in treating psychiatric disorders with a low incidence of side effects. To this end, we recent...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ACS chemical neuroscience 2017-03, Vol.8 (3), p.486-500
Hauptverfasser:	Xu, Wei, Wang, Xiaozhao, Tocker, Aaron M, Huang, Peng, Reith, Maarten E. A, Liu-Chen, Lee-Yuan, Smith, Amos B, Kortagere, Sandhya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzazepines - pharmacokinetics Butylamines - chemistry Butylamines - pharmacology CHO Cells Cricetulus Dopamine Antagonists - pharmacokinetics Dopamine Antagonists - pharmacology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics HEK293 Cells Humans Models, Molecular Molecular Docking Simulation Phosphorylation - drug effects Phosphorylation - genetics Protein Binding - drug effects Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - agonists Receptors, Dopamine D3 - genetics Receptors, Dopamine D3 - metabolism Signal Transduction - drug effects Signal Transduction - genetics Sulfur Isotopes - pharmacokinetics Transfection Tritium - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!