Amplification of PIP3 signalling by macropinocytic cups
In a role distinct from and perhaps more ancient than that in signal transduction, PIP3 and Ras help to spatially organize the actin cytoskeleton into macropinocytic cups. These large endocytic structures are extended by actin polymerization from the cell surface and have at their core an intense pa...
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| Veröffentlicht in: | Biochemical journal 2018-02, Vol.475 (3), p.643-648 |
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| container_title | Biochemical journal |
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| creator | Kay, Robert R Williams, Thomas D Paschke, Peggy |
| description | In a role distinct from and perhaps more ancient than that in signal transduction, PIP3 and Ras help to spatially organize the actin cytoskeleton into macropinocytic cups. These large endocytic structures are extended by actin polymerization from the cell surface and have at their core an intense patch of active Ras and PIP3, around which actin polymerizes, creating cup-shaped projections. We hypothesize that active Ras and PIP3 self-amplify within macropinocytic cups, in a way that depends on the structural integrity of the cup. Signalling that triggers macropinocytosis may therefore be amplified downstream in a way that depends on macropinocytosis. This argument provides a context for recent findings that signalling to Akt (an effector of PIP3) is sensitive to cytoskeletal and macropinocytic inhibitors. |
| doi_str_mv | 10.1042/BCJ20170785 |
| format | Article |
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These large endocytic structures are extended by actin polymerization from the cell surface and have at their core an intense patch of active Ras and PIP3, around which actin polymerizes, creating cup-shaped projections. We hypothesize that active Ras and PIP3 self-amplify within macropinocytic cups, in a way that depends on the structural integrity of the cup. Signalling that triggers macropinocytosis may therefore be amplified downstream in a way that depends on macropinocytosis. This argument provides a context for recent findings that signalling to Akt (an effector of PIP3) is sensitive to cytoskeletal and macropinocytic inhibitors.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/BCJ20170785</identifier><identifier>PMID: 29444849</identifier><language>eng</language><publisher>England: Portland Press Ltd</publisher><subject>Actin Cytoskeleton - chemistry ; Actin Cytoskeleton - genetics ; Cell Membrane - genetics ; Commentaries ; Dictyostelium - genetics ; Humans ; Pinocytosis - genetics ; Proto-Oncogene Proteins c-akt - chemistry ; Proto-Oncogene Proteins c-akt - genetics ; Signal Transduction - genetics</subject><ispartof>Biochemical journal, 2018-02, Vol.475 (3), p.643-648</ispartof><rights>2018 The Author(s).</rights><rights>2018 The Author(s) 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-8acfb456572f7a1b58f9588a3d6b6fbb984f372bdaa10b364b931cae0a6b080a3</citedby><cites>FETCH-LOGICAL-c381t-8acfb456572f7a1b58f9588a3d6b6fbb984f372bdaa10b364b931cae0a6b080a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813501/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813501/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29444849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kay, Robert R</creatorcontrib><creatorcontrib>Williams, Thomas D</creatorcontrib><creatorcontrib>Paschke, Peggy</creatorcontrib><title>Amplification of PIP3 signalling by macropinocytic cups</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>In a role distinct from and perhaps more ancient than that in signal transduction, PIP3 and Ras help to spatially organize the actin cytoskeleton into macropinocytic cups. 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This argument provides a context for recent findings that signalling to Akt (an effector of PIP3) is sensitive to cytoskeletal and macropinocytic inhibitors.</description><subject>Actin Cytoskeleton - chemistry</subject><subject>Actin Cytoskeleton - genetics</subject><subject>Cell Membrane - genetics</subject><subject>Commentaries</subject><subject>Dictyostelium - genetics</subject><subject>Humans</subject><subject>Pinocytosis - genetics</subject><subject>Proto-Oncogene Proteins c-akt - chemistry</subject><subject>Proto-Oncogene Proteins c-akt - genetics</subject><subject>Signal Transduction - genetics</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLAzEURoMotlZX7mWWgozePCbJbIRafFKwC12HJE1qZF5OZoT-e0daS13dxT2c794PoXMM1xgYubmbvRDAAoTMDtAYMwGpFEQeojEQzlIOBI_QSYyfAJgBg2M0IjljTLJ8jMS0bIrgg9VdqKuk9snieUGTGFaVLopQrRKzTkpt27oJVW3XXbCJ7Zt4io68LqI7284Jen-4f5s9pfPXx-fZdJ5aKnGXSm29YRnPBPFCY5NJn2dSarrkhntjcsk8FcQstcZgKGcmp9hqB5obkKDpBN1uvE1vSre0rupaXaimDaVu16rWQf3fVOFDrepvlUlMM8CD4HIraOuv3sVOlSFaVxS6cnUfFQEgTBIOckCvNujwbYyt87sYDOq3arVX9UBf7F-2Y_-6pT-aPXmG</recordid><startdate>20180214</startdate><enddate>20180214</enddate><creator>Kay, Robert R</creator><creator>Williams, Thomas D</creator><creator>Paschke, Peggy</creator><general>Portland Press Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180214</creationdate><title>Amplification of PIP3 signalling by macropinocytic cups</title><author>Kay, Robert R ; Williams, Thomas D ; Paschke, Peggy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-8acfb456572f7a1b58f9588a3d6b6fbb984f372bdaa10b364b931cae0a6b080a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Actin Cytoskeleton - chemistry</topic><topic>Actin Cytoskeleton - genetics</topic><topic>Cell Membrane - genetics</topic><topic>Commentaries</topic><topic>Dictyostelium - genetics</topic><topic>Humans</topic><topic>Pinocytosis - genetics</topic><topic>Proto-Oncogene Proteins c-akt - chemistry</topic><topic>Proto-Oncogene Proteins c-akt - genetics</topic><topic>Signal Transduction - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kay, Robert R</creatorcontrib><creatorcontrib>Williams, Thomas D</creatorcontrib><creatorcontrib>Paschke, Peggy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kay, Robert R</au><au>Williams, Thomas D</au><au>Paschke, Peggy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amplification of PIP3 signalling by macropinocytic cups</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>2018-02-14</date><risdate>2018</risdate><volume>475</volume><issue>3</issue><spage>643</spage><epage>648</epage><pages>643-648</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>In a role distinct from and perhaps more ancient than that in signal transduction, PIP3 and Ras help to spatially organize the actin cytoskeleton into macropinocytic cups. 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| fulltext | fulltext |
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| ispartof | Biochemical journal, 2018-02, Vol.475 (3), p.643-648 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Actin Cytoskeleton - chemistry Actin Cytoskeleton - genetics Cell Membrane - genetics Commentaries Dictyostelium - genetics Humans Pinocytosis - genetics Proto-Oncogene Proteins c-akt - chemistry Proto-Oncogene Proteins c-akt - genetics Signal Transduction - genetics |
| title | Amplification of PIP3 signalling by macropinocytic cups |
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