Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission of porcine endogenous retroviruses (PERVs) has impeded the clinical applicatio...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-09, Vol.357 (6357), p.1303-1307
Hauptverfasser:	Niu, Dong, Wei, Hong-Jiang, Lin, Lin, George, Haydy, Wang, Tao, Lee, I-Hsiu, Zhao, Hong-Ye, Wang, Yong, Kan, Yinan, Shrock, Ellen, Lesha, Emal, Wang, Gang, Luo, Yonglun, Qing, Yubo, Jiao, Deling, Zhao, Heng, Zhou, Xiaoyang, Wang, Shouqi, Wei, Hong, Güell, Marc, Church, George M., Yang, Luhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CRISPR CRISPR-Cas Systems Deactivation Disease Transmission, Infectious - prevention & control Endogenous retroviruses Endogenous Retroviruses - genetics Feasibility studies Gene Editing - methods Genome editing Genomes HEK293 Cells Hogs Horizontal transfer Humans Immunology Inactivation Malalties transmissibles Nuclear engineering Nuclear safety Nuclear transfer Organs Retroviridae Infections - transmission Silenciament gènic Somatic cell nuclear transfer Sus scrofa - genetics Sus scrofa - virology Swine Tissues Transplantation Transplantation, Heterologous - adverse effects Transplants Transplants & implants Xenografts Xenotransplantation Xenotrasplantament
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