Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis

The role of leukocytes in deep vein thrombosis (DVT) resolution is incompletely understood. We determined how depletion of lysozyme positive (LysM + ) cells and a switched-off type 1 immune response influences thrombus resolution. DVT was induced in 12-week-old male mice by inferior vena cava (IVC)...

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Veröffentlicht in:	Scientific reports 2018-02, Vol.8 (1), p.3013-10, Article 3013
Hauptverfasser:	Schönfelder, Tanja, Brandt, Moritz, Kossmann, Sabine, Knopp, Tanja, Münzel, Thomas, Walter, Ulrich, Karbach, Susanne H., Wenzel, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 59 631/250/2500 64 64/60 692/308/575 Blood clots Bone marrow CD11b antigen CD45 antigen Cytokines Diphtheria Diphtheria toxin Flow cytometry Gene expression Humanities and Social Sciences Immune response Inflammation Interleukin 10 Interleukin 12 Interleukin 4 Leukocytes Lysozyme Monocytes multidisciplinary Myeloid cells Rodents Science Science (multidisciplinary) Stenosis Thromboembolism Thrombosis Toxins Vascular endothelial growth factor Vascularization
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