Decreased maternal behavior and anxiety in ephrin‐A5−/− mice
During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interacti...
Gespeichert in:
| Veröffentlicht in: | Genes, brain and behavior brain and behavior, 2017-02, Vol.16 (2), p.271-284 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 284 |
|---|---|
| container_issue | 2 |
| container_start_page | 271 |
| container_title | Genes, brain and behavior |
| container_volume | 16 |
| creator | Sheleg, M. Yu, Q. Go, C. Wagner, G. C. Kusnecov, A. W. Zhou, R. |
| description | During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.
Inactivation of ephrin‐A5 reduces maternal behavior in female mice. During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety. |
| doi_str_mv | 10.1111/gbb.12319 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5812292</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4311705931</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5099-2bb75bcfcb158f9d324221efa5ac0b889dc3324829607cb144eb9d5c89ae0ee13</originalsourceid><addsrcrecordid>eNp1kM1OAjEURhujEUQXvoCZxJULoD9Tpt2YACqakLjRxF3Tdu5ACcxgB1B2Ll0aH5EnsQgSXdjk5jbtybnth9ApwQ0SVnNgTINQRuQeqpIWJnUi2NP-bh-LCjoqyxHGJGGCHKIKTTjjPGlVUecKrAddQhpN9Ax8rseRgaFeuMJHOk9DvTqYLSOXRzAdepev3j7afPX-2QwVTZyFY3SQ6XEJJ9teQ4831w_d23r_vnfXbffrlmMp69SYhBubWUO4yGTKaEwpgUxzbbERQqaWhTNBZQsnAYpjMDLlVkgNGICwGrrceKdzM4HUQj7zeqym3k20X6pCO_X3JndDNSgWigtCqaRBcL4V-OJ5DuVMjYr5-selIqLFYsloaDV0saGsL8rSQ7abQLBax61C3Oo77sCe_X7SjvzJNwDNDfDixrD836R6nc5G-QW9qoxB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1863493286</pqid></control><display><type>article</type><title>Decreased maternal behavior and anxiety in ephrin‐A5−/− mice</title><source>MEDLINE</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Sheleg, M. ; Yu, Q. ; Go, C. ; Wagner, G. C. ; Kusnecov, A. W. ; Zhou, R.</creator><creatorcontrib>Sheleg, M. ; Yu, Q. ; Go, C. ; Wagner, G. C. ; Kusnecov, A. W. ; Zhou, R.</creatorcontrib><description>During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.
Inactivation of ephrin‐A5 reduces maternal behavior in female mice. During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.</description><identifier>ISSN: 1601-1848</identifier><identifier>EISSN: 1601-183X</identifier><identifier>DOI: 10.1111/gbb.12319</identifier><identifier>PMID: 27535576</identifier><identifier>CODEN: GBBEAO</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animal behavior ; Animals ; Anxiety ; Anxiety - genetics ; Anxiety - metabolism ; Axons - metabolism ; Defects ; Eph receptor ; Ephrin-A5 - deficiency ; Ephrin-A5 - genetics ; Ephrin-A5 - metabolism ; ephrin‐A5 ; estrogen ; Female ; Male ; Maternal Behavior - physiology ; maternal care ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; nest building ; Neural Pathways - metabolism ; Neurons - metabolism ; Pregnancy ; progesterone ; pup retrieval ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor Protein-Tyrosine Kinases - metabolism ; Signal Transduction - drug effects</subject><ispartof>Genes, brain and behavior, 2017-02, Vol.16 (2), p.271-284</ispartof><rights>2016 The Authors. published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.</rights><rights>2016 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.</rights><rights>2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5099-2bb75bcfcb158f9d324221efa5ac0b889dc3324829607cb144eb9d5c89ae0ee13</citedby><cites>FETCH-LOGICAL-c5099-2bb75bcfcb158f9d324221efa5ac0b889dc3324829607cb144eb9d5c89ae0ee13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fgbb.12319$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fgbb.12319$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27535576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheleg, M.</creatorcontrib><creatorcontrib>Yu, Q.</creatorcontrib><creatorcontrib>Go, C.</creatorcontrib><creatorcontrib>Wagner, G. C.</creatorcontrib><creatorcontrib>Kusnecov, A. W.</creatorcontrib><creatorcontrib>Zhou, R.</creatorcontrib><title>Decreased maternal behavior and anxiety in ephrin‐A5−/− mice</title><title>Genes, brain and behavior</title><addtitle>Genes Brain Behav</addtitle><description>During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.
Inactivation of ephrin‐A5 reduces maternal behavior in female mice. During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.</description><subject>Animal behavior</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - genetics</subject><subject>Anxiety - metabolism</subject><subject>Axons - metabolism</subject><subject>Defects</subject><subject>Eph receptor</subject><subject>Ephrin-A5 - deficiency</subject><subject>Ephrin-A5 - genetics</subject><subject>Ephrin-A5 - metabolism</subject><subject>ephrin‐A5</subject><subject>estrogen</subject><subject>Female</subject><subject>Male</subject><subject>Maternal Behavior - physiology</subject><subject>maternal care</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>nest building</subject><subject>Neural Pathways - metabolism</subject><subject>Neurons - metabolism</subject><subject>Pregnancy</subject><subject>progesterone</subject><subject>pup retrieval</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>Signal Transduction - drug effects</subject><issn>1601-1848</issn><issn>1601-183X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kM1OAjEURhujEUQXvoCZxJULoD9Tpt2YACqakLjRxF3Tdu5ACcxgB1B2Ll0aH5EnsQgSXdjk5jbtybnth9ApwQ0SVnNgTINQRuQeqpIWJnUi2NP-bh-LCjoqyxHGJGGCHKIKTTjjPGlVUecKrAddQhpN9Ax8rseRgaFeuMJHOk9DvTqYLSOXRzAdepev3j7afPX-2QwVTZyFY3SQ6XEJJ9teQ4831w_d23r_vnfXbffrlmMp69SYhBubWUO4yGTKaEwpgUxzbbERQqaWhTNBZQsnAYpjMDLlVkgNGICwGrrceKdzM4HUQj7zeqym3k20X6pCO_X3JndDNSgWigtCqaRBcL4V-OJ5DuVMjYr5-selIqLFYsloaDV0saGsL8rSQ7abQLBax61C3Oo77sCe_X7SjvzJNwDNDfDixrD836R6nc5G-QW9qoxB</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Sheleg, M.</creator><creator>Yu, Q.</creator><creator>Go, C.</creator><creator>Wagner, G. C.</creator><creator>Kusnecov, A. W.</creator><creator>Zhou, R.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>201702</creationdate><title>Decreased maternal behavior and anxiety in ephrin‐A5−/− mice</title><author>Sheleg, M. ; Yu, Q. ; Go, C. ; Wagner, G. C. ; Kusnecov, A. W. ; Zhou, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5099-2bb75bcfcb158f9d324221efa5ac0b889dc3324829607cb144eb9d5c89ae0ee13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal behavior</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - genetics</topic><topic>Anxiety - metabolism</topic><topic>Axons - metabolism</topic><topic>Defects</topic><topic>Eph receptor</topic><topic>Ephrin-A5 - deficiency</topic><topic>Ephrin-A5 - genetics</topic><topic>Ephrin-A5 - metabolism</topic><topic>ephrin‐A5</topic><topic>estrogen</topic><topic>Female</topic><topic>Male</topic><topic>Maternal Behavior - physiology</topic><topic>maternal care</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>nest building</topic><topic>Neural Pathways - metabolism</topic><topic>Neurons - metabolism</topic><topic>Pregnancy</topic><topic>progesterone</topic><topic>pup retrieval</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptor Protein-Tyrosine Kinases - metabolism</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheleg, M.</creatorcontrib><creatorcontrib>Yu, Q.</creatorcontrib><creatorcontrib>Go, C.</creatorcontrib><creatorcontrib>Wagner, G. C.</creatorcontrib><creatorcontrib>Kusnecov, A. W.</creatorcontrib><creatorcontrib>Zhou, R.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes, brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheleg, M.</au><au>Yu, Q.</au><au>Go, C.</au><au>Wagner, G. C.</au><au>Kusnecov, A. W.</au><au>Zhou, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased maternal behavior and anxiety in ephrin‐A5−/− mice</atitle><jtitle>Genes, brain and behavior</jtitle><addtitle>Genes Brain Behav</addtitle><date>2017-02</date><risdate>2017</risdate><volume>16</volume><issue>2</issue><spage>271</spage><epage>284</epage><pages>271-284</pages><issn>1601-1848</issn><eissn>1601-183X</eissn><coden>GBBEAO</coden><abstract>During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.
Inactivation of ephrin‐A5 reduces maternal behavior in female mice. During development of the nervous system, molecular signals mediating cell–cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin‐A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin‐A5
−/− mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin‐A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>27535576</pmid><doi>10.1111/gbb.12319</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1601-1848 |
| ispartof | Genes, brain and behavior, 2017-02, Vol.16 (2), p.271-284 |
| issn | 1601-1848 1601-183X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5812292 |
| source | MEDLINE; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animal behavior Animals Anxiety Anxiety - genetics Anxiety - metabolism Axons - metabolism Defects Eph receptor Ephrin-A5 - deficiency Ephrin-A5 - genetics Ephrin-A5 - metabolism ephrin‐A5 estrogen Female Male Maternal Behavior - physiology maternal care Mice Mice, Inbred C57BL Mice, Knockout nest building Neural Pathways - metabolism Neurons - metabolism Pregnancy progesterone pup retrieval Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction - drug effects |
| title | Decreased maternal behavior and anxiety in ephrin‐A5−/− mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T21%3A39%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20maternal%20behavior%20and%20anxiety%20in%20ephrin%E2%80%90A5%E2%88%92/%E2%88%92%20mice&rft.jtitle=Genes,%20brain%20and%20behavior&rft.au=Sheleg,%20M.&rft.date=2017-02&rft.volume=16&rft.issue=2&rft.spage=271&rft.epage=284&rft.pages=271-284&rft.issn=1601-1848&rft.eissn=1601-183X&rft.coden=GBBEAO&rft_id=info:doi/10.1111/gbb.12319&rft_dat=%3Cproquest_pubme%3E4311705931%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1863493286&rft_id=info:pmid/27535576&rfr_iscdi=true |