Effects of repeated abobotulinumtoxinA injections in upper limb spasticity
ABSTRACT Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U,...
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| Veröffentlicht in: | Muscle & nerve 2018-02, Vol.57 (2), p.245-254 |
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| creator | Gracies, Jean‐Michel O'Dell, Michael Vecchio, Michele Hedera, Peter Kocer, Serdar Rudzinska‐Bar, Monika Rubin, Bruce Timerbaeva, Sofiya L. Lusakowska, Anna Boyer, François Constant Grandoulier, Anne‐Sophie Vilain, Claire Picaut, Philippe |
| description | ABSTRACT
Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500‐U dose included 500‐U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment‐emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA), angle of catch (XV3), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score. Results: The incidence of TEAEs decreased across cycles. Muscle tone reduction and XV1 remained stable across cycles, whereas XV3 and XA continued to improve at the finger, wrist, and elbow flexors. DAS and PGA improved across cycles. MFS improved best with 1,500 U. Discussion: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57: 245–254, 2018 |
| doi_str_mv | 10.1002/mus.25721 |
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Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500‐U dose included 500‐U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment‐emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA), angle of catch (XV3), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score. Results: The incidence of TEAEs decreased across cycles. Muscle tone reduction and XV1 remained stable across cycles, whereas XV3 and XA continued to improve at the finger, wrist, and elbow flexors. DAS and PGA improved across cycles. MFS improved best with 1,500 U. Discussion: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57: 245–254, 2018</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.25721</identifier><identifier>PMID: 28590525</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>active function ; Adult ; Adults ; Aged ; botulinum toxin ; Botulinum Toxins, Type A - administration & dosage ; Botulinum Toxins, Type A - adverse effects ; Botulinum Toxins, Type A - therapeutic use ; Clinical Research ; Disability Evaluation ; Double-Blind Method ; Elbow ; Elbow (anatomy) ; Elbow - physiopathology ; Female ; Fingers - physiopathology ; Flexors ; Humans ; Injections, Intramuscular ; Life Sciences ; Male ; Middle Aged ; Muscle Spasticity - drug therapy ; Muscle Spasticity - physiopathology ; Muscle Tonus - drug effects ; Muscles ; Neuromuscular Agents - administration & dosage ; Neuromuscular Agents - adverse effects ; Neuromuscular Agents - therapeutic use ; open label ; Range of Motion, Articular - drug effects ; Safety ; Spasticity ; stroke ; traumatic brain injury ; Treatment Outcome ; Upper Extremity - physiopathology ; upper limb spasticity ; Wrist ; Wrist - physiopathology</subject><ispartof>Muscle & nerve, 2018-02, Vol.57 (2), p.245-254</ispartof><rights>2017 The Authors Muscle & Nerve Published by Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5431-d62d985839513dd98da82689fadc15543f63c9840dd293e965b6d42f2a7bb5423</citedby><cites>FETCH-LOGICAL-c5431-d62d985839513dd98da82689fadc15543f63c9840dd293e965b6d42f2a7bb5423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.25721$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.25721$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28590525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04305908$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Gracies, Jean‐Michel</creatorcontrib><creatorcontrib>O'Dell, Michael</creatorcontrib><creatorcontrib>Vecchio, Michele</creatorcontrib><creatorcontrib>Hedera, Peter</creatorcontrib><creatorcontrib>Kocer, Serdar</creatorcontrib><creatorcontrib>Rudzinska‐Bar, Monika</creatorcontrib><creatorcontrib>Rubin, Bruce</creatorcontrib><creatorcontrib>Timerbaeva, Sofiya L.</creatorcontrib><creatorcontrib>Lusakowska, Anna</creatorcontrib><creatorcontrib>Boyer, François Constant</creatorcontrib><creatorcontrib>Grandoulier, Anne‐Sophie</creatorcontrib><creatorcontrib>Vilain, Claire</creatorcontrib><creatorcontrib>Picaut, Philippe</creatorcontrib><creatorcontrib>International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group</creatorcontrib><creatorcontrib>for the International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group</creatorcontrib><title>Effects of repeated abobotulinumtoxinA injections in upper limb spasticity</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500‐U dose included 500‐U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment‐emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA), angle of catch (XV3), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score. Results: The incidence of TEAEs decreased across cycles. Muscle tone reduction and XV1 remained stable across cycles, whereas XV3 and XA continued to improve at the finger, wrist, and elbow flexors. DAS and PGA improved across cycles. MFS improved best with 1,500 U. Discussion: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57: 245–254, 2018</description><subject>active function</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>botulinum toxin</subject><subject>Botulinum Toxins, Type A - administration & dosage</subject><subject>Botulinum Toxins, Type A - adverse effects</subject><subject>Botulinum Toxins, Type A - therapeutic use</subject><subject>Clinical Research</subject><subject>Disability Evaluation</subject><subject>Double-Blind Method</subject><subject>Elbow</subject><subject>Elbow (anatomy)</subject><subject>Elbow - physiopathology</subject><subject>Female</subject><subject>Fingers - physiopathology</subject><subject>Flexors</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Spasticity - drug therapy</subject><subject>Muscle Spasticity - physiopathology</subject><subject>Muscle Tonus - drug effects</subject><subject>Muscles</subject><subject>Neuromuscular Agents - administration & dosage</subject><subject>Neuromuscular Agents - adverse effects</subject><subject>Neuromuscular Agents - therapeutic use</subject><subject>open label</subject><subject>Range of Motion, Articular - drug effects</subject><subject>Safety</subject><subject>Spasticity</subject><subject>stroke</subject><subject>traumatic brain injury</subject><subject>Treatment Outcome</subject><subject>Upper Extremity - physiopathology</subject><subject>upper limb spasticity</subject><subject>Wrist</subject><subject>Wrist - physiopathology</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctOxCAUhonR6HhZ-AKmiRtdVLkUChuTycRrxrhQE3eEFqpM2lKhVeftRcd74ooT-PgOnB-AbQQPEIT4sBnCAaY5RktghKDI04wKvgxGEGU8ZUTcrYH1EGYQQsRZvgrWMKcCUkxH4OK4qkzZh8RViTedUb3RiSpc4fqhtu3Q9O7FtuPEtrOIWdeGWCZD1xmf1LYpktCp0NvS9vNNsFKpOpitj3UD3J4c30zO0unV6flkPE1LmhGUaoa14JQTQRHRsdSKY8ZFpXSJaEQqRkrBM6g1FsQIRgumM1xhlRcFzTDZAEcLbzcUjdGlaXuvatl52yg_l05Z-fuktQ_y3j1JyhHKOYmC_YXg4c-1s_FUvu3BjMA4IP6EIrv30cy7x8GEXjY2lKauVWvcECQSMIeQIJJFdPcPOnODb-MoIsWZwAwx9t289C4Eb6qvFyAo39KUMU35nmZkd37-9Iv8jC8Chwvg2dZm_r9JXt5eL5SvNSepHQ</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Gracies, Jean‐Michel</creator><creator>O'Dell, Michael</creator><creator>Vecchio, Michele</creator><creator>Hedera, Peter</creator><creator>Kocer, Serdar</creator><creator>Rudzinska‐Bar, Monika</creator><creator>Rubin, Bruce</creator><creator>Timerbaeva, Sofiya L.</creator><creator>Lusakowska, Anna</creator><creator>Boyer, François Constant</creator><creator>Grandoulier, Anne‐Sophie</creator><creator>Vilain, Claire</creator><creator>Picaut, Philippe</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>201802</creationdate><title>Effects of repeated abobotulinumtoxinA injections in upper limb spasticity</title><author>Gracies, Jean‐Michel ; O'Dell, Michael ; Vecchio, Michele ; Hedera, Peter ; Kocer, Serdar ; Rudzinska‐Bar, Monika ; Rubin, Bruce ; Timerbaeva, Sofiya L. ; Lusakowska, Anna ; Boyer, François Constant ; Grandoulier, Anne‐Sophie ; Vilain, Claire ; Picaut, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5431-d62d985839513dd98da82689fadc15543f63c9840dd293e965b6d42f2a7bb5423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>active function</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>botulinum toxin</topic><topic>Botulinum Toxins, Type A - administration & dosage</topic><topic>Botulinum Toxins, Type A - adverse effects</topic><topic>Botulinum Toxins, Type A - therapeutic use</topic><topic>Clinical Research</topic><topic>Disability Evaluation</topic><topic>Double-Blind Method</topic><topic>Elbow</topic><topic>Elbow (anatomy)</topic><topic>Elbow - physiopathology</topic><topic>Female</topic><topic>Fingers - physiopathology</topic><topic>Flexors</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Spasticity - drug therapy</topic><topic>Muscle Spasticity - physiopathology</topic><topic>Muscle Tonus - drug effects</topic><topic>Muscles</topic><topic>Neuromuscular Agents - administration & dosage</topic><topic>Neuromuscular Agents - adverse effects</topic><topic>Neuromuscular Agents - therapeutic use</topic><topic>open label</topic><topic>Range of Motion, Articular - drug effects</topic><topic>Safety</topic><topic>Spasticity</topic><topic>stroke</topic><topic>traumatic brain injury</topic><topic>Treatment Outcome</topic><topic>Upper Extremity - physiopathology</topic><topic>upper limb spasticity</topic><topic>Wrist</topic><topic>Wrist - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gracies, Jean‐Michel</creatorcontrib><creatorcontrib>O'Dell, Michael</creatorcontrib><creatorcontrib>Vecchio, Michele</creatorcontrib><creatorcontrib>Hedera, Peter</creatorcontrib><creatorcontrib>Kocer, Serdar</creatorcontrib><creatorcontrib>Rudzinska‐Bar, Monika</creatorcontrib><creatorcontrib>Rubin, Bruce</creatorcontrib><creatorcontrib>Timerbaeva, Sofiya L.</creatorcontrib><creatorcontrib>Lusakowska, Anna</creatorcontrib><creatorcontrib>Boyer, François Constant</creatorcontrib><creatorcontrib>Grandoulier, Anne‐Sophie</creatorcontrib><creatorcontrib>Vilain, Claire</creatorcontrib><creatorcontrib>Picaut, Philippe</creatorcontrib><creatorcontrib>International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group</creatorcontrib><creatorcontrib>for the International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gracies, Jean‐Michel</au><au>O'Dell, Michael</au><au>Vecchio, Michele</au><au>Hedera, Peter</au><au>Kocer, Serdar</au><au>Rudzinska‐Bar, Monika</au><au>Rubin, Bruce</au><au>Timerbaeva, Sofiya L.</au><au>Lusakowska, Anna</au><au>Boyer, François Constant</au><au>Grandoulier, Anne‐Sophie</au><au>Vilain, Claire</au><au>Picaut, Philippe</au><aucorp>International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group</aucorp><aucorp>for the International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of repeated abobotulinumtoxinA injections in upper limb spasticity</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2018-02</date><risdate>2018</risdate><volume>57</volume><issue>2</issue><spage>245</spage><epage>254</epage><pages>245-254</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>ABSTRACT
Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500‐U dose included 500‐U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment‐emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA), angle of catch (XV3), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score. Results: The incidence of TEAEs decreased across cycles. Muscle tone reduction and XV1 remained stable across cycles, whereas XV3 and XA continued to improve at the finger, wrist, and elbow flexors. DAS and PGA improved across cycles. MFS improved best with 1,500 U. Discussion: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57: 245–254, 2018</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28590525</pmid><doi>10.1002/mus.25721</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | active function Adult Adults Aged botulinum toxin Botulinum Toxins, Type A - administration & dosage Botulinum Toxins, Type A - adverse effects Botulinum Toxins, Type A - therapeutic use Clinical Research Disability Evaluation Double-Blind Method Elbow Elbow (anatomy) Elbow - physiopathology Female Fingers - physiopathology Flexors Humans Injections, Intramuscular Life Sciences Male Middle Aged Muscle Spasticity - drug therapy Muscle Spasticity - physiopathology Muscle Tonus - drug effects Muscles Neuromuscular Agents - administration & dosage Neuromuscular Agents - adverse effects Neuromuscular Agents - therapeutic use open label Range of Motion, Articular - drug effects Safety Spasticity stroke traumatic brain injury Treatment Outcome Upper Extremity - physiopathology upper limb spasticity Wrist Wrist - physiopathology |
| title | Effects of repeated abobotulinumtoxinA injections in upper limb spasticity |
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