Local application of lactoferrin promotes bone regeneration in a rat critical‐sized calvarial defect model as demonstrated by micro‐CT and histological analysis

Lactoferrin is a multifunctional glycoprotein with therapeutic potential for bone tissue engineering. The aim of this study was to assess the efficacy of local application of lactoferrin on bone regeneration. Five‐millimetre critical‐sized defects were created over the right parietal bone in 64 Spra...

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Veröffentlicht in:	Journal of tissue engineering and regenerative medicine 2018-01, Vol.12 (1), p.e620-e626
Hauptverfasser:	Gao, Ryan, Watson, Maureen, Callon, Karen E., Tuari, Donna, Dray, Michael, Naot, Dorit, Amirapu, Satya, Munro, Jacob T., Cornish, Jillian, Musson, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone growth bone healing bone regeneration Bone Regeneration - drug effects Calvaria calvarial defect Cattle Collagen Computed tomography Concentration (composition) Defects Disease Models, Animal Gels Glycoproteins Histology Lactoferrin Lactoferrin - pharmacology Lamellar bone Male Nonunion Organ Size - drug effects Parietal bone Rats Rats, Sprague-Dawley Regeneration (physiology) Regenerative medicine Rodents Skin Skull - diagnostic imaging Skull - drug effects Skull - pathology Skull - physiopathology Tissue engineering X-Ray Microtomography
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