Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation

Spermatogenesis depends on endocrine, autocrine and paracrine communications along the hypothalamus-pituitary-gonad axis. Bisphenol A (BPA), an estrogen-mimic endocrine disrupting chemical, is an environmental contaminant used to manufacture polycarbonate plastics and epoxy resins with toxic effects...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2018-02, Vol.8 (1), p.2961-12, Article 2961
Hauptverfasser:	Chianese, Rosanna, Viggiano, Andrea, Urbanek, Konrad, Cappetta, Donato, Troisi, Jacopo, Scafuro, Marika, Guida, Maurizio, Esposito, Grazia, Ciuffreda, Loreta Pia, Rossi, Francesco, Berrino, Liberato, Fasano, Silvia, Pierantoni, Riccardo, De Angelis, Antonella, Meccariello, Rosaria
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 14 14/19 38 631/443/494 692/163/2743 82 82/58 Animals Apoptosis Apoptosis - drug effects Autocrine signalling Benzhydryl Compounds - blood Benzhydryl Compounds - toxicity Bisphenol A Body weight Body Weight - drug effects Body weight gain Chronic exposure Contaminants DNA Damage Dose-Response Relationship, Drug Down-Regulation - drug effects Drinking water Endocrine disruptors Energy balance Energy metabolism Epoxy resins Estrogens Female Gene Expression Regulation, Enzymologic - drug effects Homeostasis Humanities and Social Sciences Hypothalamus Lactation Male multidisciplinary NAD Offspring Oxidative metabolism Oxidative stress Oxidative Stress - drug effects Paracrine signalling Phenols - blood Phenols - toxicity Pituitary Placenta Polycarbonate Rats Rats, Wistar Reactive oxygen species Science Science (multidisciplinary) SIRT1 protein Sirtuin 1 - metabolism Spermatogenesis Spermatogenesis - drug effects Testis - drug effects Testis - metabolism Testis - physiology Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!