Combination of nutritional polyphenols supplementation with exercise training counteracts insulin resistance and improves endurance in high-fat diet-induced obese rats
Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity and IR require further investigation. Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese...
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| creator | Lambert, Karen Hokayem, Marie Thomas, Claire Fabre, Odile Cassan, Cécile Bourret, Annick Bernex, Florence Feuillet-Coudray, Christine Notarnicola, Cécile Mercier, Jacques Avignon, Antoine Bisbal, Catherine |
| description | Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity and IR require further investigation. Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese IR rats with high-fat diet (EXOPP) to the effect of high-fat diet alone (HF) or with a nutritional supplementation of grape polyphenols (PP) or with endurance exercise (EXO) during 8 wks. We observed an improvement of systemic and skeletal muscle insulin sensitivity in EXO and EXOPP rats. EXOPP rats compared to HF rats presented a lower insulinemia and HOMA-IR with higher liver and muscle glycogen contents. Interestingly, EXOPP rats had a 68% enhanced endurance capacity compared to EXO rats with also a higher activation of AMPK compared to sedentary and EXO rats with increased lipid oxidation. Together, our results suggest that grape polyphenols supplementation combined with exercise has a synergistic effect by increasing muscle lipid oxidation and sparing glycogen utilization which thus enhances endurance capacity. Our data highlight that in cases of established obesity and IR, the combination of nutritional grape polyphenols supplementation and exercise heighten and intensify their individual metabolic effects. |
| doi_str_mv | 10.1038/s41598-018-21287-z |
| format | Article |
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Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese IR rats with high-fat diet (EXOPP) to the effect of high-fat diet alone (HF) or with a nutritional supplementation of grape polyphenols (PP) or with endurance exercise (EXO) during 8 wks. We observed an improvement of systemic and skeletal muscle insulin sensitivity in EXO and EXOPP rats. EXOPP rats compared to HF rats presented a lower insulinemia and HOMA-IR with higher liver and muscle glycogen contents. Interestingly, EXOPP rats had a 68% enhanced endurance capacity compared to EXO rats with also a higher activation of AMPK compared to sedentary and EXO rats with increased lipid oxidation. Together, our results suggest that grape polyphenols supplementation combined with exercise has a synergistic effect by increasing muscle lipid oxidation and sparing glycogen utilization which thus enhances endurance capacity. Our data highlight that in cases of established obesity and IR, the combination of nutritional grape polyphenols supplementation and exercise heighten and intensify their individual metabolic effects.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-21287-z</identifier><identifier>PMID: 29440695</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/319/1642/393 ; 692/163/2743/393 ; 82 ; 82/80 ; Diet ; Dietary supplements ; Endocrinology and metabolism ; Food and Nutrition ; Fruits ; Glycogen ; High fat diet ; Human health and pathology ; Humanities and Social Sciences ; Insulin ; Insulin resistance ; Life Sciences ; Lipid peroxidation ; Liver ; Metabolism ; multidisciplinary ; Obesity ; Oxidation ; Physical training ; Polyphenols ; Rodents ; Science ; Science (multidisciplinary) ; Skeletal muscle ; Synergistic effect ; Tissues and Organs</subject><ispartof>Scientific reports, 2018-02, Vol.8 (1), p.2885-10, Article 2885</ispartof><rights>The Author(s) 2018</rights><rights>2018. 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Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese IR rats with high-fat diet (EXOPP) to the effect of high-fat diet alone (HF) or with a nutritional supplementation of grape polyphenols (PP) or with endurance exercise (EXO) during 8 wks. We observed an improvement of systemic and skeletal muscle insulin sensitivity in EXO and EXOPP rats. EXOPP rats compared to HF rats presented a lower insulinemia and HOMA-IR with higher liver and muscle glycogen contents. Interestingly, EXOPP rats had a 68% enhanced endurance capacity compared to EXO rats with also a higher activation of AMPK compared to sedentary and EXO rats with increased lipid oxidation. Together, our results suggest that grape polyphenols supplementation combined with exercise has a synergistic effect by increasing muscle lipid oxidation and sparing glycogen utilization which thus enhances endurance capacity. 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Jacques</au><au>Avignon, Antoine</au><au>Bisbal, Catherine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of nutritional polyphenols supplementation with exercise training counteracts insulin resistance and improves endurance in high-fat diet-induced obese rats</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-02-13</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>2885</spage><epage>10</epage><pages>2885-10</pages><artnum>2885</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity and IR require further investigation. Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese IR rats with high-fat diet (EXOPP) to the effect of high-fat diet alone (HF) or with a nutritional supplementation of grape polyphenols (PP) or with endurance exercise (EXO) during 8 wks. We observed an improvement of systemic and skeletal muscle insulin sensitivity in EXO and EXOPP rats. EXOPP rats compared to HF rats presented a lower insulinemia and HOMA-IR with higher liver and muscle glycogen contents. Interestingly, EXOPP rats had a 68% enhanced endurance capacity compared to EXO rats with also a higher activation of AMPK compared to sedentary and EXO rats with increased lipid oxidation. Together, our results suggest that grape polyphenols supplementation combined with exercise has a synergistic effect by increasing muscle lipid oxidation and sparing glycogen utilization which thus enhances endurance capacity. 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| subjects | 631/443/319/1642/393 692/163/2743/393 82 82/80 Diet Dietary supplements Endocrinology and metabolism Food and Nutrition Fruits Glycogen High fat diet Human health and pathology Humanities and Social Sciences Insulin Insulin resistance Life Sciences Lipid peroxidation Liver Metabolism multidisciplinary Obesity Oxidation Physical training Polyphenols Rodents Science Science (multidisciplinary) Skeletal muscle Synergistic effect Tissues and Organs |
| title | Combination of nutritional polyphenols supplementation with exercise training counteracts insulin resistance and improves endurance in high-fat diet-induced obese rats |
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