Maternal Obesity Affects Inflammatory and Iron Indices in Umbilical Cord Blood
Objective To determine the impact of maternal obesity and gestational weight gain across pregnancy on fetal indices of inflammation and iron status. Study design Eighty-five healthy term newborns delivered via elective cesarean were categorized by 2 maternal body mass index (BMI) thresholds; above o...
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| Veröffentlicht in: | The Journal of pediatrics 2016-05, Vol.172, p.20-28 |
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| creator | Dosch, Natalie C., BS Guslits, Elyssa F., MD Weber, Morgan B., BS Murray, Shannon E., BS Ha, Barbara, BA, MSPH Coe, Christopher L., PhD Auger, Anthony P., PhD Kling, Pamela J., MD |
| description | Objective To determine the impact of maternal obesity and gestational weight gain across pregnancy on fetal indices of inflammation and iron status. Study design Eighty-five healthy term newborns delivered via elective cesarean were categorized by 2 maternal body mass index (BMI) thresholds; above or below 30 kg/m2 or above or below 35 kg/m2 . Umbilical cord plasma levels of C-reactive protein, interleukin (IL)-6, tumor necrosis factor (TNF)-α, ferritin, and hepcidin were assayed. Cytokines released by phytohemagglutinin-stimulated umbilical cord mononuclear cells (MNCs) were assayed. Results Maternal class II obesity, defined as BMI of 35 kg/m2 and above, predicted higher C-reactive protein and TNF-α in umbilical cord plasma ( P |
| doi_str_mv | 10.1016/j.jpeds.2016.02.023 |
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Study design Eighty-five healthy term newborns delivered via elective cesarean were categorized by 2 maternal body mass index (BMI) thresholds; above or below 30 kg/m2 or above or below 35 kg/m2 . Umbilical cord plasma levels of C-reactive protein, interleukin (IL)-6, tumor necrosis factor (TNF)-α, ferritin, and hepcidin were assayed. Cytokines released by phytohemagglutinin-stimulated umbilical cord mononuclear cells (MNCs) were assayed. Results Maternal class II obesity, defined as BMI of 35 kg/m2 and above, predicted higher C-reactive protein and TNF-α in umbilical cord plasma ( P < .05 for both), and also proinflammatory cytokines (IL-1β, IL-6, and TNF-α) from stimulated MNC ( P < .05 for all). The rise in plasma TNF-α and MNC TNF-α was not linear but occurred when the threshold of BMI 35 kg/m2 was reached ( P < .005, P < .06). Poorer umbilical cord iron indices were associated with maternal obesity. When ferritin was low, IL-6 was higher ( P < .04), but this relationship was present primarily when maternal BMI exceeded 35 kg/m2 ( P < .03). Ferritin was correlated with hepcidin ( P < .0001), but hepcidin was unrelated to either maternal BMI or inflammatory indices. Conclusions Class II obesity and above during pregnancy is associated with fetal inflammation in a threshold fashion. Although maternal BMI negatively impacted fetal iron status, hepcidin, related to obesity in adults, was related to iron status and not obesity in fetuses. Pediatricians should be aware of these relationships.]]></description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2016.02.023</identifier><identifier>PMID: 26970931</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Body Mass Index ; Cytokines - blood ; Female ; Fetal Blood - metabolism ; Fetus - metabolism ; Humans ; Infant, Newborn ; Inflammation - complications ; Inflammation - metabolism ; Iron - blood ; Male ; Maternal-Fetal Exchange ; Obesity - blood ; Pediatrics ; Pregnancy</subject><ispartof>The Journal of pediatrics, 2016-05, Vol.172, p.20-28</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-c25ce9427b38f62524c93b9066434d56b7c0921324fb25d48b81b3661e8b90dd3</citedby><cites>FETCH-LOGICAL-c514t-c25ce9427b38f62524c93b9066434d56b7c0921324fb25d48b81b3661e8b90dd3</cites><orcidid>0000-0002-6098-2646 ; 0000-0003-1658-8702</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347616001852$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26970931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dosch, Natalie C., BS</creatorcontrib><creatorcontrib>Guslits, Elyssa F., MD</creatorcontrib><creatorcontrib>Weber, Morgan B., BS</creatorcontrib><creatorcontrib>Murray, Shannon E., BS</creatorcontrib><creatorcontrib>Ha, Barbara, BA, MSPH</creatorcontrib><creatorcontrib>Coe, Christopher L., PhD</creatorcontrib><creatorcontrib>Auger, Anthony P., PhD</creatorcontrib><creatorcontrib>Kling, Pamela J., MD</creatorcontrib><title>Maternal Obesity Affects Inflammatory and Iron Indices in Umbilical Cord Blood</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description><![CDATA[Objective To determine the impact of maternal obesity and gestational weight gain across pregnancy on fetal indices of inflammation and iron status. Study design Eighty-five healthy term newborns delivered via elective cesarean were categorized by 2 maternal body mass index (BMI) thresholds; above or below 30 kg/m2 or above or below 35 kg/m2 . Umbilical cord plasma levels of C-reactive protein, interleukin (IL)-6, tumor necrosis factor (TNF)-α, ferritin, and hepcidin were assayed. Cytokines released by phytohemagglutinin-stimulated umbilical cord mononuclear cells (MNCs) were assayed. Results Maternal class II obesity, defined as BMI of 35 kg/m2 and above, predicted higher C-reactive protein and TNF-α in umbilical cord plasma ( P < .05 for both), and also proinflammatory cytokines (IL-1β, IL-6, and TNF-α) from stimulated MNC ( P < .05 for all). The rise in plasma TNF-α and MNC TNF-α was not linear but occurred when the threshold of BMI 35 kg/m2 was reached ( P < .005, P < .06). Poorer umbilical cord iron indices were associated with maternal obesity. When ferritin was low, IL-6 was higher ( P < .04), but this relationship was present primarily when maternal BMI exceeded 35 kg/m2 ( P < .03). Ferritin was correlated with hepcidin ( P < .0001), but hepcidin was unrelated to either maternal BMI or inflammatory indices. Conclusions Class II obesity and above during pregnancy is associated with fetal inflammation in a threshold fashion. Although maternal BMI negatively impacted fetal iron status, hepcidin, related to obesity in adults, was related to iron status and not obesity in fetuses. Pediatricians should be aware of these relationships.]]></description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Fetus - metabolism</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Inflammation - complications</subject><subject>Inflammation - metabolism</subject><subject>Iron - blood</subject><subject>Male</subject><subject>Maternal-Fetal Exchange</subject><subject>Obesity - blood</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EokvhFyChHLlkGX_EcQ5UKis-Vir0AD1bjj0BL4m92NlK--9x2FIBF6SRLNvvO2PPM4Q8p7CmQOWr3Xq3R5fXrGzWwErwB2RFoWtrqTh_SFYAjNVctPKMPMl5BwCdAHhMzpjsWug4XZFPH82MKZixuu4x-_lYXQ4D2jlX2zCMZprMHNOxMsFV2xRDOXXeYq58qG6m3o_eFusmJle9GWN0T8mjwYwZn92t5-Tm3dsvmw_11fX77ebyqrYNFXNtWWOxE6ztuRoka5iwHe87kFJw4RrZtxY6RjkTQ88aJ1SvaM-lpKiKyjl-Ti5OefeHfkJnMczJjHqf_GTSUUfj9d83wX_TX-OtbhSoBlRJ8PIuQYo_DphnPflscRxNwHjImrZKtKJr6SLlJ6lNMeeEw30ZCnohoXf6Fwm9kNDASvDievHnC-89v1tfBK9PAix9uvWYdLYeg0XnUwGgXfT_KXDxj9-OPiw8vuMR8y4eFqzlJzoXg_68DMMyC1QCUNUw_hPxNK9x</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Dosch, Natalie C., BS</creator><creator>Guslits, Elyssa F., MD</creator><creator>Weber, Morgan B., BS</creator><creator>Murray, Shannon E., BS</creator><creator>Ha, Barbara, BA, MSPH</creator><creator>Coe, Christopher L., PhD</creator><creator>Auger, Anthony P., PhD</creator><creator>Kling, Pamela J., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6098-2646</orcidid><orcidid>https://orcid.org/0000-0003-1658-8702</orcidid></search><sort><creationdate>20160501</creationdate><title>Maternal Obesity Affects Inflammatory and Iron Indices in Umbilical Cord Blood</title><author>Dosch, Natalie C., BS ; Guslits, Elyssa F., MD ; Weber, Morgan B., BS ; Murray, Shannon E., BS ; Ha, Barbara, BA, MSPH ; Coe, Christopher L., PhD ; Auger, Anthony P., PhD ; Kling, Pamela J., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-c25ce9427b38f62524c93b9066434d56b7c0921324fb25d48b81b3661e8b90dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Fetus - metabolism</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Inflammation - complications</topic><topic>Inflammation - metabolism</topic><topic>Iron - blood</topic><topic>Male</topic><topic>Maternal-Fetal Exchange</topic><topic>Obesity - blood</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dosch, Natalie C., BS</creatorcontrib><creatorcontrib>Guslits, Elyssa F., MD</creatorcontrib><creatorcontrib>Weber, Morgan B., BS</creatorcontrib><creatorcontrib>Murray, Shannon E., BS</creatorcontrib><creatorcontrib>Ha, Barbara, BA, MSPH</creatorcontrib><creatorcontrib>Coe, Christopher L., PhD</creatorcontrib><creatorcontrib>Auger, Anthony P., PhD</creatorcontrib><creatorcontrib>Kling, Pamela J., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dosch, Natalie C., BS</au><au>Guslits, Elyssa F., MD</au><au>Weber, Morgan B., BS</au><au>Murray, Shannon E., BS</au><au>Ha, Barbara, BA, MSPH</au><au>Coe, Christopher L., PhD</au><au>Auger, Anthony P., PhD</au><au>Kling, Pamela J., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Obesity Affects Inflammatory and Iron Indices in Umbilical Cord Blood</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>172</volume><spage>20</spage><epage>28</epage><pages>20-28</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract><![CDATA[Objective To determine the impact of maternal obesity and gestational weight gain across pregnancy on fetal indices of inflammation and iron status. Study design Eighty-five healthy term newborns delivered via elective cesarean were categorized by 2 maternal body mass index (BMI) thresholds; above or below 30 kg/m2 or above or below 35 kg/m2 . Umbilical cord plasma levels of C-reactive protein, interleukin (IL)-6, tumor necrosis factor (TNF)-α, ferritin, and hepcidin were assayed. Cytokines released by phytohemagglutinin-stimulated umbilical cord mononuclear cells (MNCs) were assayed. Results Maternal class II obesity, defined as BMI of 35 kg/m2 and above, predicted higher C-reactive protein and TNF-α in umbilical cord plasma ( P < .05 for both), and also proinflammatory cytokines (IL-1β, IL-6, and TNF-α) from stimulated MNC ( P < .05 for all). The rise in plasma TNF-α and MNC TNF-α was not linear but occurred when the threshold of BMI 35 kg/m2 was reached ( P < .005, P < .06). Poorer umbilical cord iron indices were associated with maternal obesity. When ferritin was low, IL-6 was higher ( P < .04), but this relationship was present primarily when maternal BMI exceeded 35 kg/m2 ( P < .03). Ferritin was correlated with hepcidin ( P < .0001), but hepcidin was unrelated to either maternal BMI or inflammatory indices. Conclusions Class II obesity and above during pregnancy is associated with fetal inflammation in a threshold fashion. Although maternal BMI negatively impacted fetal iron status, hepcidin, related to obesity in adults, was related to iron status and not obesity in fetuses. Pediatricians should be aware of these relationships.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26970931</pmid><doi>10.1016/j.jpeds.2016.02.023</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6098-2646</orcidid><orcidid>https://orcid.org/0000-0003-1658-8702</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Body Mass Index Cytokines - blood Female Fetal Blood - metabolism Fetus - metabolism Humans Infant, Newborn Inflammation - complications Inflammation - metabolism Iron - blood Male Maternal-Fetal Exchange Obesity - blood Pediatrics Pregnancy |
| title | Maternal Obesity Affects Inflammatory and Iron Indices in Umbilical Cord Blood |
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