Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease

Alcoholic liver disease (ALD) ranks among major causes of morbidity and mortality. Diet and crosstalk between the gut and liver are important determinants of ALD. We evaluated the effects of different types of dietary fat and ethanol on the gut microbiota composition and metabolic activity and the e...

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Veröffentlicht in:	The American journal of pathology 2016-04, Vol.186 (4), p.765-776
Hauptverfasser:	Kirpich, Irina A, Petrosino, Joseph, Ajami, Nadim, Feng, Wenke, Wang, Yuhua, Liu, Yanlong, Beier, Juliane I, Barve, Shirish S, Yin, Xinmin, Wei, Xiaoli, Zhang, Xiang, McClain, Craig J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dietary Fats - metabolism Dietary Fats, Unsaturated - metabolism Disease Models, Animal Ethanol - pharmacology Gastrointestinal Microbiome - drug effects Liver - metabolism Liver Diseases, Alcoholic - metabolism Male Mice, Inbred C57BL Pathology Triglycerides - metabolism
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