Discovery and in Vitro Optimization of 3‑Sulfamoylbenzamides as ROMK Inhibitors

Inhibitors of the renal outer medullary potassium channel (ROMK) show promise as novel mechanism diuretics, with potentially lower risk of diuretic-induced hypokalemia relative to current thiazide and loop diuretics. Here, we report the identification of a novel series of 3-sulfamoylbenzamide ROMK i...

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Veröffentlicht in:	ACS medicinal chemistry letters 2018-02, Vol.9 (2), p.125-130
Hauptverfasser:	Sammons, Matthew F, Kharade, Sujay V, Filipski, Kevin J, Boehm, Markus, Smith, Aaron C, Shavnya, Andre, Fernando, Dilinie P, Dowling, Matthew S, Carpino, Philip A, Castle, Neil A, Zellmer, Shannon G, Antonio, Brett M, Gosset, James R, Carlo, Anthony, Denton, Jerod S
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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