Preclinical Development of CD38-Targeted [ 89 Zr]Zr-DFO-Daratumumab for Imaging Multiple Myeloma

Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal morbidity. Despite improvements in survival, heterogeneity in response remains a major challenge in MM. Cluster of differentiation 38 (CD38) is a type II transmembrane glycoprotein overexpressed in myeloma c...

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Veröffentlicht in:	Journal of Nuclear Medicine 2018-02, Vol.59 (2), p.216-222
Hauptverfasser:	Ghai, Anchal, Maji, Dolonchampa, Cho, Nicholas, Chanswangphuwana, Chantiya, Rettig, Michael, Shen, Duanwen, DiPersio, John, Akers, Walter, Dehdashti, Farrokh, Achilefu, Samuel, Vij, Ravi, Shokeen, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - metabolism Affinity Animal models Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Background noise Binding Bioluminescence Blood diseases Cancer CD38 antigen Cell Line, Tumor Computed tomography Confocal microscopy Conjugation Cytometry Deferoxamine Dosage Flow cytometry Glycoproteins Human performance Humans Imaging Immunodeficiency Immunoreactivity Immunotherapy Ionization Isothiocyanate Isotope Labeling Lesions Lymphocytes B Mass spectrometry Mass spectroscopy Mice Microscopy Monoclonal antibodies Morbidity Multiple myeloma Multiple Myeloma - diagnostic imaging Multiple Myeloma - metabolism Multiple Myeloma - pathology Noise control Oncology Positron emission Positron Emission Tomography Computed Tomography - methods Radioisotopes Receptor density Signaling Targeted cancer therapy Thin layer chromatography Tissue Distribution Tomography Tumors Zirconium
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