Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E7

The major causative agent of cervical cancer is human papilloma virus (HPV); the viral proteins E6 and E7 induce carcinogenesis through the inactivation of the host tumor-suppressor gene. Therefore, the stable expression of specific inhibitors of E6 and E7 in cancer cells is expected to provide effe...

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Veröffentlicht in:	International journal of oncology 2018-03, Vol.52 (3), p.687-696
Hauptverfasser:	Sato, Naoto, Saga, Yasushi, Uchibori, Ryosuke, Tsukahara, Tomonori, Urabe, Masashi, Kume, Akihiro, Fujiwara, Hiroyuki, Suzuki, Mitsuaki, Ozawa, Keiya, Mizukami, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer therapies Cell cycle Cell lines Cervical cancer Chemotherapy Dependoviruses Flow cytometry Gene expression Genetic aspects Human papillomavirus Infections Plasmids Proteins Radiation therapy Risk factors Tumors Vectors (Biology)
Online-Zugang:	Volltext
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